Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling

Journal of Experimental Medicine

Volumn 197, Issue 12, 2003, Pages 1787-1791

  Erridge, Clett ^a   Stewart, John ^a   Poxton, Ian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Innate immunity; Lipopolysaccharides; Single nucleotide polymorphism monocytes; Toll like receptor 4

Indexed keywords

ASPARTIC ACID; BACTERIUM LIPOPOLYSACCHARIDE; DNA; GLYCINE; ISOLEUCINE; THREONINE; TOLL LIKE RECEPTOR 4;

ARTICLE; ATHEROSCLEROSIS; BACTEREMIA; BACTERIAL INFECTION; BACTEROIDES FRAGILIS; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNITY; MONOCYTE; NEISSERIA MENINGITIDIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STAPHYLOCOCCUS AUREUS; YERSINIA PESTIS;

ASPARTIC ACID; GRAM-NEGATIVE BACTERIA; HUMANS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MONOCYTES; MUTATION; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; THREONINE; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0037866985     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20022078     Document Type: Article

References (23)

1. Aderem, A., and R.J. Ulevitch. 2000. Toll-like receptors in the induction of the innate immune response. Nature 406:782-786.
2. Hirschfeld, M., J.J. Weis, V. Toschchakov, C.A. Salkowski, M.J. Cody, D.C. Ward, N. Quereshi, S.M. Michalek, and S.N. Vogel. 2001. Signalling by Toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect. Immun. 69:1477-1482.
3. Werts, C., R.I. Tapping, J.C. Mathison, T.H. Chuang, V. Kravchenko, I. Saint Girons, D.A. Haake, P.J. Godowski, F. Hayashi, A. Ozinsky, et al. 2001. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat. Immunol. 2:346-352.
4. Lorenz, E., K.L. Frees, and D.A. Schwartz. 2001. Determination of the TLR4 genotype using allele-specific PCR. Biotechniques. 31:22-24.
5. Arbour, N.C., E. Lorenz, B.C. Schutte, J. Zabner, J.N. Kline, M. Jones, K. Frees, J.L. Watt, and D.A. Schwartz. 2000. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25:187-191.
6. Tanamoto, K., U. Zahringer, G.R. Mckenzie, C. Galanos, E.T. Rietschel, O. Luderitz, S. Kusumoto, and T. Shiba. 1984. Biological activities of synthetic lipid A analogues: Pyrogenicity, lethal toxicity, anticomplement activity and induction of gelation of limulus amoebocyte lysate. Infect. Immun. 44:421-426.
7. Erridge, C., E. Bennett-Guerrero, and I.R. Poxton. 2002. Structure and function of lipopolysaccharides. Microbes Infect. 4:837-851.
8. Hancock, I.C., and I.R. Poxton. 1998. Bacterial Cell Surface Techniques. Wiley, Chichester, UK. 488 pp.
9. Hirschfeld, M., Y. Ma, J.H. Weis, S.N. Vogel, and J.J. Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signalling through both human and murine toll-like receptor 2. J. Immunol. 165:618-622.
10. Kiechl, S., E. Lorenz, M. Reindl, C.J. Wiedermann, F. Oberhollenzer, E. Bonora, J. Willeit, and D.A. Schwartz. 2002. Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347:185-192.
11. Lien, E., T.J. Sellati, A. Yoshimura, T.H. Flo, G. Rawadi, R.W. Finberg, J.D. Carroll, T. Espevik, R.R. Ingalls, J.D Radolf, and D.T. Golenbock. 1999. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274:33419-33425.
12. Ogawa, T., Y. Asai, M. Hashimoto, O. Takeuchi, T. Kurita, Y. Yoshikai, K. Miyake, and S. Akira. 2002. Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4 and myeloid differentiation factor 88-dependent signaling pathway. Int. Immunol. 14:1325-1332.
13. Kline, J.N., J.D. Cowden, G.W. Hunninghake, B.C. Schutte, J.L. Watt, C.L. Wohlford-Lenane, L.S. Powers, M.P. Jones, and D.A. Schwartz. 1999. Variable airway responsiveness to inhaled lipopolysaccharide. Am. J. Respir. Crit. Care Med. 160:297-303.
14. Manthey, C.L., and S.N. Vogel. 1994. Elimination of trace endotoxin protein from rough chemotype LPS. J. Endotoxin Res. 1:84-92.
15. Lorenz, E., J.P. Mira, K.L. Frees, and D.A. Schwartz. 2002. Relevance of mutations in the TLR4 receptor in patients with Gram-negative septic shock. Arch. Intern. Med. 162:1028-1032.
16. Lorenz, E., M. Hallman, R. Martilla, R. Haataja, and D.A. Schwartz. 2002. Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population. Pcdiatr. Res. 52:373-376.
17. Lorenz, E., D.A. Schwartz, P.J. Martin, T. Gooley, M.T. Lin, J.W. Chien, J.A. Hansen, and J. G. Clark. 2001. Association of TLR4 mutations and the risk for acute GVHD after HLA matched sibling hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 7:384-387.
18. Read, R.C., J. Pullin, S. Gregory, R. Borrow, E.B. Kaczmarski, F.S. Giovine, S.K. Dower, C. Cannings, and A.G. Wilson. 2001. A functional polymorphism of Toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J. Infect. Dis. 184:640-642.
19. Kurt-Jones, E.A., L. Popova, L. Kwinn, L.M. Haynes, L.P. Jones, R.A. Tripp, E.E. Walsh, M.W. Freeman, D.T. Golenbock, L.J. Anderson, and R.W. Finberg. 2000. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1:398-401.
20. Okamura, Y., M. Watari, E.S. Jerud, D.W. Young, S.T. Ishizaka, J. Rose, J.C. Chow, and J.F. Strauss iii. 2001. The extra domain A of fibronectin activates Toll-like receptor 4. J. Biol. Chem. 276:10229-10233.
21. Ohashi, K., V. Burkart, S. Flohe, and H. Kolb. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor 4 complex. J. Immunol. 164:558-561.
22. Sasu, S., D. La Verda, N. Qureshi, D.T. Golenbock, and D. Beasly. 2001. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via Toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ. Res. 89:244-250.
23. Xu, Q. 2002. Role of heat shock proteins in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 22:1547-1559.