Mechanistic studies of a flavin-dependent thymidylate synthase

Biochemistry

Volumn 43, Issue 32, 2004, Pages 10295-10301

  Agrawal, Nitish ^a   Lesley, Scott A ^b   Kuhn, Peter ^c   Kohen, Amnon ^a  

^a University of Iowa ^*  (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOASSAY; BIOSYNTHESIS; CATALYSIS; DNA; ENZYME KINETICS; GENES;

DRUG DEVELOPMENT; PATHOGENS;

BIOCHEMISTRY;

DIHYDROFOLATE REDUCTASE; FLAVIN DEPENDENT THYMIDYLATE SYNTHASE; FLAVOPROTEIN; PTERIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DNA REPLICATION; DRUG DEVELOPMENT; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; GENE; ISOTOPE LABELING; MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; THERMOTOGA MARITIMA; THYA GENE;

CATALYSIS; COMPUTER SIMULATION; FLAVIN-ADENINE DINUCLEOTIDE; KINETICS; MASS SPECTROMETRY; NADP; OXIDATION-REDUCTION; THERMOTOGA MARITIMA; THYMIDYLATE SYNTHASE;

EUKARYOTA; THERMOTOGA; THERMOTOGA MARITIMA;

EID: 4043057882     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0490439     Document Type: Article

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