Efficient synthesis of 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-((E)-2-(2- [18F]fluoropyridin-4-yl)vinyl)pyridine ([18F]NIDA 52289), a very high affinity radioligand for nicotinic acetylcholine receptors

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 47, Issue 6, 2004, Pages 385-392

  Zhang, Yi ^a   Hall, Andrew W ^a   Horti, Andrew G ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

18F; A 85380; Nicotinic acetylcholine receptors; Positron emission tomography

Indexed keywords

POSITRONS; PYRIDINE; SYNTHESIS (CHEMICAL);

18F; A-85380; ACETYLCHOLINE RECEPTOR; EFFICIENT SYNTHESIS; HIGH AFFINITY; METHOXY; NICOTINIC ACETYLCHOLINE; NICOTINIC ACETYLCHOLINE RECEPTOR; RADIOLIGANDS; SYNTHESISED;

POSITRON EMISSION TOMOGRAPHY;

2 FLUORO 3 (2 AZETIDINYLMETHOXY)PYRIDINE F 18; 3 (2 AZETIDINYLMETHOXY)PYRIDINE; 6 CHLORO 3 [(2 AZETIDINYL)METHOXY] 5 [2 (2 FLUOROPYRIDIN 4 YL)VINYL]PYRIDINE F 18; 6 CHLORO 3 [[1 (TERT BUTOXYCARBONYL) 2 AZETIDINYL]METHOXY] 5 [2 (2 BROMOPYRIDIN 4 YL)VINYL]PYRIDINE; EPIBATIDINE; FLUORINE 18; NICOTINIC RECEPTOR; NIDA 52289; POLYETHER DERIVATIVE; PYRIDINE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DEPROTECTION REACTION; DRUG STRUCTURE; FLUORINATION; LIGAND BINDING; NUCLEOPHILIC FLUORINATION; POSITRON EMISSION TOMOGRAPHY; PURIFICATION; QUANTUM YIELD; RADIOACTIVITY; RADIOCHEMICAL PURITY; RADIOCHEMICAL YIELD; RADIOCHEMISTRY; RADIOSYNTHESIS; SPECIFIC RADIOACTIVITY; SYNTHESIS;

EID: 4043054386     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.824     Document Type: Article

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