Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 5, 2008, Pages 1472-1477

  Fang, Chong ^a,c   Bauman, Joseph D ^b   Das, Kalyan ^b   Remorino, Amanda ^a   Arnold, Eddy ^b   Hochstrasser, Robin M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2D IR spectroscopy; Ultrafast protein response; Vibrational relaxation

Indexed keywords

NITRILE; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ENZYME INHIBITOR; PYRIMIDINE DERIVATIVE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DIFFUSION; DRUG PROTEIN BINDING; ENZYME INHIBITION; FREQUENCY MODULATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; VIBRATION; CHEMISTRY; METHODOLOGY; PROTEIN CONFORMATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; ENZYME INHIBITORS; HIV REVERSE TRANSCRIPTASE; HUMANS; NITRILES; PROTEIN CONFORMATION; PYRIMIDINES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 40349094606     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709320104     Document Type: Article

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