Effect of conjugated linoleic acid on bovine mammary cell growth, apoptosis and stearoyl Co-A desaturase gene expression

Domestic Animal Endocrinology

Volumn 34, Issue 3, 2008, Pages 284-292

  Keating, Aileen F ^a,b   Zhao, Feng Qi ^b   Finucane, Kiera A ^b   Glimm, David R ^a   Kennelly, John J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

Apoptosis; Conjugated linoleic acid; Insulin; Mammary gland; Stearoyl Co A desaturase

Indexed keywords

ACYL COENZYME A DESATURASE; CONJUGATED LINOLEIC ACID;

ANIMAL; APOPTOSIS; ARTICLE; CATTLE; CELL CULTURE; CELL DIVISION; CYTOLOGY; DNA FRAGMENTATION; DRUG EFFECT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; NICK END LABELING; UDDER;

ANIMALS; APOPTOSIS; CATTLE; CELL DIVISION; CELLS, CULTURED; DNA FRAGMENTATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENETIC VECTORS; IN SITU NICK-END LABELING; LINOLEIC ACIDS, CONJUGATED; MAMMARY GLANDS, ANIMAL; STEAROYL-COA DESATURASE; TRANSFECTION;

BOVINAE;

EID: 40249094567     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2007.08.005     Document Type: Article

References (37)

1. Ip C., Chin S.F., Scimeca J.A., and Pariza M.W. Mammary cancer prevention by conjugated dienoic derivatives of linoleic acid. Cancer Res. 51 (1991) 6118-6124
2. Ip C., Singh M., Thompson H.J., and Scimeca J.A. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res. 54 (1994) 1212-1215
3. Ip C., Thompson H., Banni S., Zhu Z., Loftus T., and Darcy K. Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. Cancer Res. 57 (1997) 5067-5072
4. Ip C., Banni S., Angioni E., Carta G., McGinley J., Thompson H.J., et al. Conjugated linoleic acid-enriched butterfat alters mammary gland morphogenesis and reduces cancer risk. J. Nutr. 129 (1999) 2135-2142
5. Belury M.A., Mahon A., and Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J. Nutr. 133 (2003) 257S-260S
6. Terpstra A.H. Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Am. J. Clin. Nutr. 79 (2004) 352-361
7. Griinari J.M., Chouinard P.Y., and Bauman D.E. Trans fatty acid hypothesis of milk fat depression revised. Proc. Cornell Nutr. Conf. Feed Manuf. (1997) 208-216
8. Griinari J.M., Corl B.A., Lacy S.H., Chouinard P.Y., Nurmela K.V.V., and Bauman D.E. Conjugated linoleic acid is synthesised endogenously in lactating cows by delta-9 desaturase. J. Nutr. 130 (2000) 2285-2291
9. Corl B.A., Baumgard L.H., Dwyer D.A., Griinari J.M., Phillips B.S., and Bauman D.E. The role of delta-9 desaturase in the production of cis-9, trans-11 CLA. J. Nutr. Biochem. 12 (2001) 622-630
10. Kay J.K., Mackle T.R., Auldist M.J., Thomson N.A., and Bauman D.E. Endogenous synthesis of cis-9, trans-11 conjugated linoleic acid in dairy cows fed fresh pasture. J. Dairy Sci. 87 (2004) 369-378
11. Baumgard L.H., Corl B.A., Dwyer D.A., Saebo A., and Bauman D.E. Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. Am. J. Physiol. Integr. Comp. Physiol. 278 (2000) R179-R184
12. Baumgard L.H., Sangster J.K., and Bauman D.E. Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). J. Nutr. 131 (2001) 1764-1769
13. Peterson D.G., Baumgard L.H., and Bauman D.E. Short communication: milk fat response to low doses of trans-10, cis-12 conjugated linoleic acid (CLA). J. Dairy Sci. 85 (2002) 1764-1766
14. Bell J.A., and Kennelly J.J. Short communication: postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in Holstein cows. J. Dairy Sci. 86 (2003) 1321-1324
15. Moore C.H., Hafliger III H.C., Mendivil O.B., Sanders S.R., Bauman D.E., and Baumgard L.H. Increasing amounts of conjugated linoleic acid (CLA) progressively reduces milk fat synthesis immediately postpartum. J. Dairy Sci. 87 (2005) 1886-1895
16. Chouinard P.Y., Corneau L., Barbano D.M., Metzger L.E., and Bauman D.E. Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. J. Nutr. 129 (1999) 1579-1584
17. Mackle T.R., Kay J.K., Auldist M.J., McGibbon A.K.H., Philpott B.A., Baumgard L.H., et al. Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. J. Dairy Sci. 86 (2003) 644-652
18. O'Shea M., Devery R., Lawless F., Murphy J., and Stanton C. Milk fat conjugated linoleic acid (CLA) inhibits growth of human mammary MCF-7 cancer cells. Anticancer Res. 20 (2000) 3591-3601
19. Hubbard N.E., Lim D., and Erickson K.L. Conjugated linoleic acid alters matrix metalloproteinases of metastatic mouse mammary tumour cells. J. Nutr. 137 (2007) 1423-1429
20. Ou L., Ip C., Lisafeld B., and Ip M.M. Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. Biochem. Biophys. Res. Commun. 356 (2007) 1044-1049
21. Keating A.F., Kennelly J.J., and Zhao F.Q. Characterization and regulation of the bovine Stearoyl-CoA desaturase gene promoter. Biochem. Biophys. Res. Commun. 344 (2006) 233-240
22. Ntambi J.M. The regulation of stearoyl CoA desaturase (SCD). Prog. Lipid. Res. 34 (1995) 139-150
23. Miller P.J., Finucane K.A., Hughes M., and Zhao F.Q. Cloning and expression of bovine glucose transporter GLUT12. Mamm. Genome 16 (2005) 873-883
24. Bell J.A., Griinari J.M., and Kennelly J.J. Effect of safflower oil, flaxseed oil, monensin, and vitamin E on concentration of conjugated linoleic acid in bovine milk fat. J. Dairy Sci. 89 (2006) 733-748
25. Lamparska-Przybysz M., Galjkowska B., and Motyl T. Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin. J. Physiol. Pharmacol. 56 (2005) 159-179
26. Gao S., and Scott R.E. Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis. J. Cell Physiol. 197 (2003) 445-452
27. Earnshaw W.C. Nuclear changes in apoptosis. Curr. Opin. Cell Biol. 7 (1995) 337-343
28. Martelli A.M., Zweyer M., Ochs R.L., Tazzari P.L., Tebellini G., Narducci P., et al. Nuclear apoptotic changes: an overview. J. Cell. Biochem. 82 (2001) 634-646
29. Rogalinska M. Alterations in cell nuclei during apoptosis. Cell. Mol. Biol. Lett. 7 (2002) 995-1018
30. Beppu F., Hosokawa M., Tanaka L., Kohno H., Tanaka T., and Miyashita K. Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. J. Nutr. Biochem. 17 (2006) 830-836
31. Collier R.J., Steining C.M., Pollard B.C., VanBaale M.J., Baumgard L.H., Gentry P.C., et al. Use of gene expression microarrays for evaluating environmental stress tolerance at the cellular level in cattle. J. Anim. Sci. 84 (2006) Suppl. E1-13
32. Kim S.K., and Novak R.F. The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol. Ther. 113 (2007) 88-120
33. Brown J.M., Boysen M.S., Chung S., Fabiyi O., Morrison R.F., Mandrup S., et al. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signalling by adipocytokines. J. Biol. Chem. 279 (2004) 26735-26747
34. Migletta A., Bozzo F., Bocca C., Gabriel L., Trombetta A., Belotti S., et al. Conjugated linoleic acid induces apoptosis in MDA-MB-231 breast cancer cells through ERK/MAPK signalling and mitochondrial pathway. Cancer Lett. 234 (2006) 149-157
35. Scaglia N., and Igal R.A. Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J. Biol. Chem. 280 (2005) 25339-25349
36. Eberle D., Hegarty B., Bossard P., Ferre P., and Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86 (2004) 839-848
37. Foretz M., Pacot C., Dugail I., Lemarchand P., Guichard C., Le Liepvre X., et al. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol. Cell Biol. 19 (1999) 3760-3768