The effects of tolerance on allograft damage caused by the innate immune system

Transplantation

Volumn 85, Issue 3, 2008, Pages 314-322

  Hoerbelt, Ruediger ^a   Benjamin, Christopher L ^a   Shoji, Tsuyoshi ^a   Houser, Stuart L ^a   Muniappan, Ashok ^a   Hasse, Rebecca S ^a   Ledgerwood, Levi G ^a   Allan, James S ^a   Sachs, David H ^a   Madsen, Joren C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cytokines; Heart; Inflammation; Swine; Tolerance

Indexed keywords

CYCLOSPORIN A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RECOMBINANT GAMMA INTERFERON;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CONTINUOUS INFUSION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART TRANSPLANTATION; INBRED STRAIN; INNATE IMMUNITY; ISOGRAFT; KIDNEY TRANSPLANTATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; SWINE;

ACUTE DISEASE; ANIMALS; CORONARY VESSELS; ENDOTHELIUM; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE TOLERANCE; IMMUNITY, NATURAL; INFUSIONS, INTRA-ARTERIAL; INTERFERON TYPE II; RECOMBINANT PROTEINS; SWINE; SWINE, MINIATURE; TRANSPLANTATION, HOMOLOGOUS;

EID: 40049092131     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181629b05     Document Type: Article

References (76)

1. Diamond AS, Gill RG. An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts. J Immunol 2000; 165: 247.
2. Ring GH, Saleem S, Dai Z, et al. Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts. Transplantation 1999; 67: 1362.
3. Fairchild RL, Vanbuskirk AM, Kondo T, et al. Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. Transplantation 1997; 63: 1807.
4. Magnone M, Holley JL, Shapiro R, et al. Interferon-alpha-induced acute renal allograft rejection. Transplantation 1995; 59: 1068.
5. Zhao DX, Hu Y, Miller GG, et al. Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN- inducible T cell alpha chemoattractant in human cardiac allografts: Association with cardiac allograft vasculopathy and acute rejection. J Immunol 2002; 169: 1556.
6. Rosenberg AS, Finbloom DS, Maniero TG, et al. Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody. J Immunol 1990; 144: 4648.
7. Koga S, Auerbach MB, Engeman TM, et al. T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-gamma-induced chemokine Mig. J Immunol 1999; 163: 4878.
8. Tellides G, Tereb DA, Kirkiles-Smith NC, et al. Interferon-gamma elicits arteriosclerosis in the absence of leukocytes. Nature 2000; 403: 201.
9. Hosken NA, Bevan MJ. Defective presentation of endogenous antigen by a cell line expressing class I molecules. Science 1990; 248: 367.
10. Nagano H, Libby P, Taylor MK, et al. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: Role of interferon-gamma. Am J Pathol 1998; 152: 1187.
11. Daemen MA, van't Veer C, Wolfs TG, Buurman WA. Ischemia/reperfusion- induced IFN-gamma up-regulation: Involvement of IL-12 and IL-18. J Immunol 1999; 162: 5506.
12. Day YJ, Huang L, Ye H, et al. Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: The role of CD4+ T cells and IFN-gamma. J Immunol 2006; 176: 3108.
13. Takada M, Nadeau KC, Hancock WW, et al. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 1998; 65: 1533.
14. Weiss S, Kotsch K, Francuski M, et al. Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation. Am J Transplant 2007; 7: 1584.
15. Terasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995; 333: 333.
16. Gjertson DW. A multi-factor analysis of kidney graft outcomes at one and five years posttransplantation: 1996 UNOS Update. Clin Transpl 1996: 343.
17. Wilhelm MJ, Pratschke J, Beato F, et al. Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation 2000; 102: 2426.
18. Pratschke J, Wilhelm MJ, Kusaka M, et al. Accelerated rejection of renal allografts from brain-dead donors. Ann Surg 2000; 232: 263.
19. Pennington LR, Lunney JK, Sachs DH. Transplantation in miniature swine: VIII. Recombination within the major histocompatibility complex of miniature swine. Transplantation 1981; 31: 66.
20. Mezrich JD, Haller GW, Arn JS, et al. Histocompatible miniature swine: An inbred large-animal model. Transplantation 2003; 75: 904.
21. Madsen JC. Cardiac allograft vasculopathy in miniature swine: Utility of a large animal model. Graft 1998; 1(suppl II): 41-44.
22. Madsen JC, Yamada K, Allan JS, et al. Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine. Transplantation 1998; 65: 304.
23. Yamada K, Mawulawde K, Menard MT, et al. Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: The effect of augmentation of donor antigen load. J Thorac Cardiovasc Surg 2000; 119: 709.
24. Lee RS, Yamada K, Womer KL, et al. Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. J Immunol 2000; 164: 3434.
25. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart rejection study group. J Heart Transplant 1990; 9: 587.
26. Choo JK, Seebach JD, Nickeleit V, et al. Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium. Transplantation 1997; 64: 1315.
27. Houser SL, Benjamin LC, Wain JC, et al. Constitutive expression of major histocompatibility complex class II antigens in pulmonary epithelium and endothelium varies among different species. Transplantation 2004; 77: 605.
28. Seebach JD, Schneider MK, Comrack CA, et al. Immortalized bone-marrow derived pig endothelial cells. Xenotransplantation 2001; 8: 48.
29. Lee RS, Yamada K, Houser SL, et al. Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy. Proc Natl Acad Sci U S A 2001; 98: 3276.
30. Madsen JC, Sachs DH, Fallon JT, Weissman NJ. Cardiac allograft vasculopathy in partially inbred miniature swine. I. Time course, pathology, and dependence on immune mechanisms. J Thorac Cardiovasc Surg 1996; 111: 1230.
31. Mezrich J, Yamada K, Sachs DH, Madsen JC. Regulatory T cells generated by the kidney may mediate the beneficial immune effects of combining kidney with heart transplantation. Surgery 2004; 135: 473.
32. Mezrich JD, Kesselheim JA, Johnston DR, et al. The role of regulatory cells in miniature Swine rendered tolerant to cardiac allografts by donor kidney cotransplantation. Am J Transplant 2003; 3: 1107.
33. Ijzermans JN, Bijma AM, v.d.Meide PH, et al. Antitumor and immunomodulating effects of recombinant interferon-gamma in rats. In: Kirchner H, Schellekens H, eds. The Biology of the Interferon System 1984. New York: Elsevier, 1985: 475.
34. Ijzermans JN, Bouwman E, de Bruin RW, et al. Treatment with rIFN-gamma has no effect on cardiac allograft rejection. Immunology 1991; 73: 243.
35. Mezrich J, Yamada K, Sachs DH, Madsen JC. Regulatory T cells generated by the kidney may mediate the beneficial immune effects of combining kidney with heart transplantation. Surgery 2004; 135: 473.
36. Hobart M, Ramassar V, Goes N, et al. The induction of class I and II major histocompatibility complex by allogeneic stimulation is dependent on the transcription factor interferon regulatory factor 1 (IRF-1): Observations in IRF-1 knockout mice. Transplantation 1996; 62: 1895.
37. Hobart M, Ramassar V, Goes N, et al. IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo. J Immunol 1997; 158: 4260.
38. Goes N, Sims T, Urmson J, et al. Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma. J Immunol 1995; 155: 4559.
39. Goes N, Urmson J, Hobart M, Halloran PF. The unique role of interferon-gamma in the regulation of MHC expression on arterial endothelium. Transplantation 1996; 62: 1889.
40. Halloran PF, Autenried P, Ramassar V, et al. Local T cell responses induce widespread MHC expression. Evidence that IFN-gamma induces its own expression in remote sites. J Immunol 1992; 148: 3837.
41. Panitch HS, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987; 1: 893.
42. Shoskes DA, Parfrey NA, Halloran PF. Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse. Transplantation 1990; 49: 201.
43. Groenewegen G, Buurman WA, van der Linden CJ. Lymphokine dependence of in vivo expression of MHC class II antigens by endothelium. Nature 1985; 316: 361.
44. Roncarolo MG, Gregori S, Battaglia M, et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006; 212: 28.
45. O'Garra A, Vieira P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol 2007; 7: 425.
46. Moore KW, de Waal MR, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683.
47. Willems F, Marchant A, Delville JP, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 1007.
48. de Waal M, Haanen J, Spits H, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915.
49. Blancho G, Gianello P, Germana S, et al. Molecular identification of porcine interleukin 10: Regulation of expression in a kidney allograft model. Proc Natl Acad Sci U S A 1995; 92: 2800.
50. Lee RS, Rusche JR, Maloney ME, et al. CTLA4Ig-induced linked regulation of allogeneic T cell responses. J Immunol 2001; 166: 1572.
51. Mezrich JD, Yamada K, Lee RS, et al. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population. Transplantation 2003; 76: 625.
52. Mezrich JD, Kesselheim JA, Johnston DR, et al. The role of regulatory cells in miniature swine rendered tolerant to cardiac allografts by donor kidney cotransplantation. Am J Transplant 2003; 3: 1107.
53. Wood KJ, Sawitzki B. Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol 2006; 27: 183.
54. Hidalgo LG, Halloran PF. Role of IFN-gamma in allograft rejection. Crit Rev Immunol 2002; 22: 317.
55. Zhang J. Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease. J Clin Invest 2007; 117: 871.
56. O'Connell PJ, Pacheco-Silva A, Nickerson PW, et al. Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J Immunol 1993; 150: 1093.
57. Famulski KS, Einecke G, Reeve J, et al. Changes in the transcriptome in allograft rejection: IFN-gamma-induced transcripts in mouse kidney allografts. Am J Transplant 2006; 6: 1342.
58. Markees TG, Phillips NE, Gordon EJ, et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest 1998; 101: 2446.
59. Sayegh MH, Akalin E, Hancock WW, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869.
60. Hidalgo LG, Urmson J, Halloran PF. IFN-gamma decreases CTL generation by limiting IL-2 production: A feedback loop controlling effector cell production. Am J Transplant 2005; 5: 651.
61. Halloran PF, Afrouzian M, Ramassar V, et al. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 2001; 158: 215.
62. Konieczny BT, Dai Z, Elwood ET, et al. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998; 160: 2059.
63. Hassan AT, Dai Z, Konieczny BT, et al. Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-gamma: Implications for long-term allograft acceptance. Transplantation 1999; 68: 124.
64. Mele TS, Kneteman NM, Zhu LF, et al. IFN-gamma is an absolute requirement for spontaneous acceptance of liver allografts. Am J Transplant 2003; 3: 942.
65. Sawitzki B, Kingsley CI, Oliveira V, et al. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005; 201: 1925.
66. Guillonneau C, Hill M, Hubert FX, et al. CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase. J Clin Invest 2007; 117: 1096.
67. Gianello PR, Fishbein JM, Sachs DH. Tolerance to primarily vascularized allografts in miniature swine. Immunol Rev 1993; 133: 19.
68. El Sawy T, Miura M, Fairchild R. Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. Am J Pathol 2004; 165: 147.
69. Zhai Y, Shen XD, Hancock WW, et al. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol 2006; 176: 6313.
70. Howard TK, Klintmalm GB, Cofer JB, et al. The influence of preservation injury on rejection in the hepatic transplant recipient. Transplantation 1990; 49: 103.
71. Martins PN, Chandraker A, Tullius SG. Modifying graft immunogenicity and immune response prior to transplantation: Potential clinical applications of donor and graft treatment. Transpl Int 2006; 19: 351.
72. Land WG. The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation. Transplantation 2005; 79: 505.
73. Takada M, Chandraker A, Nadeau KC, et al. The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury. J Clin Invest 1997; 100: 1199.
74. Chandraker A, Takada M, Nadeau KC, et al. CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury. Kidney Int 1997; 52: 1678.
75. Akyürek LM, Johnsson C, Lange D, et al. Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants: Influence of Fasmediated apoptosis. J Clin Invest 1998; 101: 2889.
76. Pratschke J, Wilhelm MJ, Kusaka M, et al. Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation 1999; 67: 343.