Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis

Medical Hypotheses

Volumn 70, Issue 4, 2008, Pages 826-830

  Blewett, Megan M ^a  

^a HARVARD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; BACTERIAL ANTIGEN; BBGL 2 ANTIGEN; GALACTOSYLCERAMIDE; GALAGSL ANTIGEN; MYELIN; UNCLASSIFIED DRUG;

ARTICLE; BORRELIA BURGDORFERI; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; MYELIN SHEATH; NATURAL KILLER T CELL; PRIORITY JOURNAL; SPHINGOMONAS;

BORRELIA BURGDORFERI; SPHINGOMONAS;

EID: 39849098747     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.07.037     Document Type: Article

References (67)

1. G.J. Siegel B.W. Agranoff R.W. Albers S.K. Fisher M.D. Uhler Basic neurochemistry: molecular cellular and medical aspects 1998 Lippincott Williams and Wilkins New York
2. J. Marcus S. Honigbaum S. Shroff K. Honke J. Rosenbluth J.L. Dupree Sulfatide is essential for the maintenance of CNS myelin and axon structure Glia 53 4 2006 372 381
3. J.L. Dupree T. Coetzee K. Suzuki B. Popko Myelin abnormalities in mice deficient in galactocerebroside and sulfatide J Neurocytol 27 9 1998 649 659
4. A. Bosio E. Binczek W. Stoffel Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis Proc Natl Acad Sci USA 93 23 1996 13280 13285
5. T. Coetzee N. Fujita J. Dupree Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability Cell 86 2 1996 209 219
6. G.M. Franklin L. Nelson Environmental risk factors in multiple sclerosis Neurology 61 8 2001 1032 1034
7. J.F. Kurtzke Multiple sclerosis in time and space – geographic clues to cause J Neurovirol 6 S2 2000 S134 S140
8. F.C. Westfall Abnormal hormonal control of gut hydrolytic enzymes causes autoimmune attack on the CNS by production of immune-mimic and adjuvant molecules: a comprehensive explanation for the induction of multiple sclerosis Med Hypotheses 68 2 2007 364 369
9. C. Wolfson P. Talbot Bacterial infection as a cause of multiple sclerosis Lancet 360 9330 2002 352 353
10. P. Stinissen J. Raus J. Zhang Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies Crit Rev Immunol 17 1 1997 33 75
11. K.C. Williams E. Ulvestad W.F. Hickey Immunology of multiple sclerosis Clin Neurosci 2 3-4 1994 229 245
12. S. Dhib-Jalbut Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosis Neurology 68 22 S3 2007 S13 S21
13. J.E. Libbey L.L. McCoy R.S. Fujinami Molecular mimicry in multiple sclerosis Int Rev Neurobiol 79 2007 127 147
14. P.H. Lalive T. Menge C. Delarasse Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis Proc Natl Acad Sci USA 103 7 2006 2280 2285
15. M. Reindl C. Linington U. Brehm Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study Brain 122 Pt 11 1999 2047 2056
16. R. Egg M. Reindl F. Deisenhammer C. Linington T. Berger Anti-MOG and anti-MBP antibody subclasses in multiple sclerosis Mult Scler 7 5 2001 285 289
17. N.K. de Rosbo A. Ben-Nun T-cell responses to myelin antigens in multiple sclerosis; relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein J Autoimmun 11 4 1998 287 299
18. T. Menge P.H. Lalive H.C. von Budingen B. Cree S.L. Hauser C.P. Genain Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis J Allergy Clin Immunol 116 2 2005 453 459
19. J. Kuhle C. Pohl M. Mehling Lack of association between antimyelin antibodies and progression to multiple sclerosis N Engl J Med 356 4 2007 371 378
20. K.C. O’Connor T. Chitnis D.E. Griffin Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions J Neuroimmunol 136 1–2 2003 140 148
21. G. De Libero L. Mori Self glycosphingolipids: new antigens recognized by autoreactive T lymphocytes News Physiol Sci 18 2003 71 76
22. G. De Libero A. Donda H.J. Gober A new aspect in glycolipid biology: glycosphingolipids as antigens recognized by T lymphocytes Neurochem Res 27 7-8 2002 675 685
23. A. Shamshiev A. Donda I. Carena L. Mori L. Kappos G. De Libero Self glycolipids as T-cell autoantigens Eur J Immunol 29 5 1999 1667 1675
24. B.T. Sadatipour J.M. Greer M.P. Pender Increased circulating antiganglioside antibodies in primary and secondary progressive multiple sclerosis Ann Neurol 47 5 2000 684 685
25. J.L. Kantner S. Narayana P.P. Ho Lipid microarrays identify key mediators of autoimmune brain inflammation Nat Med 12 1 2006 138 143
26. G. De Libero A.P. Moran H.J. Gober Bacterial infections promote T cell recognition of self-glycolipids Immunity 22 6 2005 763 772
27. M. Kronenberg Y. Kinjo Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition Immunity 22 6 2005 657 659
28. H. Moses S. Sriram An infectious basis for multiple sclerosis: perspectives on the role of Chlamydia pneumoniae and other agents BioDrugs 15 3 2001 199 206
29. C. Contini R. Cultrera S. Seraceni M. Castellazzi E. Granieri E. Fainardi Cerebrospinal fluid molecular demonstration of Chlamydia pneumoniae DNA is associated to clinical and brain magnetic resonance imaging activity in a subset of patients with relapse-remitting multiple sclerosis Mult Scler 10 4 2004 360 369
30. T. Dong-Si J. Weber Y.B. Liu Increased prevalence of and gene transcription by Chlamydia pneumoniae in cerebrospinal fluid of patients with relapsing–remitting multiple sclerosis J Neurol 251 5 2004 542 547
31. E. Maida Immunological reactions against Mycoplasma pneumoniae in multiple sclerosis: preliminary findings J Neurol 229 2 1983 103 111
32. M.A. Lana-Peixoto Multiple sclerosis and positive Lyme serology Arq Neuropsiquiatr 52 4 1994 566 571
33. M. Fritzsche Chronic Lyme borreliosis at the root of multiple sclerosis – is a cure with antibiotics attainable? Med Hypotheses 64 3 2005 438 448
34. O. Brorson S.H. Brorson T.H. Henriksen P.R. Skogen R. Schoven Association between multiple sclerosis and cystic structures in cerebrospinal fluid Infection 29 6 2001 315 319
35. J. Chmielewska-Badora E. Cisak J. Dutkiewicz Lyme borreliosis and multiple sclerosis: any connection? A seroepidemic study Ann Agric Environ Med 7 2 2000 141 143
36. G. Savely Neuralgia and demyelinating plaques: MS or Lyme disease? Adv Nurse Pract 13 9 2005 20
37. J.C. Garcia-Monco J. Miro Jornet B. Fernandez Villar J.L. Benach A. Geurrero Espejo J.A. Berciano Multiple sclerosis or Lyme disease? A diagnosis problem of exclusion Med Clin (Barc) 94 18 1990 685 688
38. A. Kamaratos S. Kokkoris J. Protopsaltis Simultaneous bilateral facial palsy in a diabetic patient Diabetes Care 27 2 2004 623 624
39. L. Strueby B. Nair A. Kirk R.M. Taylor-Gjevre Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta Scand J Rheumatol 34 6 2005 485 488
40. A.C. Steere D. Gross A.L. Meyer B.T. Huber Autoimmune mechanisms in antibiotic treatment-resistant Lyme arthritis J Autoimmun 16 3 2001 263 268
41. D.M. Gross T. Forsthuber M. Tary-Lehmann Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis Science 281 5377 1998 703 706
42. J.S. Brown Geographic correlation of multiple sclerosis with tick-borne diseases Mult Scler 1 1996 257 261
43. S.R. Schwid A.D. Goodman D.H. Mattson Autoimmune hyperthyroidism in patients with multiple sclerosis treated with interferon beta-1b Arch Neurol 54 9 1997 1169 1190
44. S. Benvenga F. Guarneri M. Vaccaro L. Santarpia F. Trimarchi Homologies between proteins of Borrelia burgdorferi and thyroid autoantigens Thyroid 14 11 2004 964 966
45. A. Alonso S.S. Jisk H. Jick M.A. Hernan Antibiotic use and risk of multiple sclerosis Am J Epidemiol 163 11 2006 997 1002
46. P.K. Coyle Borrelia burgdorferi antibodies in multiple sclerosis patients Neurology 39 6 1989 760 761
47. P.K. Coyle L.B. Krupp C. Doscher Significance of reactive Lyme serology in multiple sclerosis Ann Neurol 34 5 1993 745 747
48. G. Ben-Menacem J. Kubler-Kielb B. Coxon A. Yergev R. Schneerson A newly discovered cholesteryl galactoside from Borrelia burgdorferi Proc Natl Acad Sci USA 100 13 2003 7913 7918
49. E. Tupin Y. Kinjo M. Kronenberg The unique role of natural killer T cells in the response to microorganisms Nat Rev Microbiol 5 6 2007 405 417
50. N. Kasai A.R. Pachner R.K. Yu Anti-glycolipid antibodies and their immune complexes in multiple sclerosis J Neurol Sci 75 1 1986 33 42
51. J.M. Fry S. Weissbarth G.M. Lehrer M.B. Bornstein Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue cultures Science 183 124 1974 540 542
52. C.S. Raine A.B. Johnson D.M. Marcus A. Suzuki M.B. Bornstein Demyelination in vitro: absorption studies demonstrate that galactocerebroside is a major target J Neurol Sci 52 1 1981 117 131
53. K.K. Menon S.J. Piddlesden C.C. Bernard Demyelinating antibodies to myelin oligodendrocyte glycoprotein and galactocerebroside induce degradation of myelin basic protein in isolated human myelin J Neurochem 69 1 1997 214 222
54. A.J. Loughlin C.A. Copelman A. Hall Myelination and remyelination of aggregate rat brain cell cultures enriched with macrophages J Neurosci Res 47 4 1997 384 392
55. H.D. Shine C. Readhead B. Popko L. Hood R.L. Sidman Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis J Neurochem 58 1 1992 342 349
56. A. Bendelac P.B. Savage T. Luc The biology of NKT cells Annu Rev Immunol 25 2007 297 336
57. D. Wu D.M. Zajonc M. Fujio Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d Proc Natl Acad Sci USA 103 11 2006 3972 3977
58. E. Kobayashi K. Motoki T. Uchida H. Fukushima Y. Koezuka KRN7000, a novel immunomodulator, and its antitumor activities Oncol Res 7 10–11 1995 529 534
59. J. Mattner K.L. Debord N. Ismail Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature 434 7032 2005 525 529
60. Y. Kinjo D. Wu G. Kim Recognition of bacterial glycosphingolipids by natural killer T cells Nature 434 7032 2005 520 525
61. V. Sriram W. Du J. Gervay-Hague R.R. Brutkiewicz Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells Eur J Immunol 35 6 2005 1692 1701
62. K.J. Hammond D.I. Godfrey NKT cells: potential targets for autoimmune disease therapy? Tissue Antigens 59 2002 353 363
63. M. Yamazaki L. Thorne M. Mikolajczak R.W. Armentrout T.J. Pollock Linkage of genes essential for synthesis of a polysaccharide capsule in Sphingomonas strain S88 J Bacteriol 178 9 1996 2676 2687
64. Y. Kinjo E. Tupin D. Wu F. Masakazu Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria Nat Immunol 7 9 2006 978 985
65. D. Zhou J. Mattner C. Cantu Lysosomal glycosphingolipid recognition by NKT cells Science 306 5702 2004 1786 1789
66. S. Porubsky A.O. Speak B. Luckow V. Cerundolo F.M. Platt H.J. Grone Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency Proc Natl Acad Sci USA 104 14 2007 5977 5982
67. L. Linsen V. Somers P. Stinissen Immunoregulation of autoimmunity by natural killer T cells Hum Immunol 66 12 2005 1193 1202