Constraining the amide bond in N-Sulfonylated dipeptide VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1688-1691

  Chang, Linda L ^a   Yang, Ginger X ^a   McCauley, Ermengilda ^a   Mumford, Richard A ^a   Schmidt, John A ^a   Hagmann, William K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bicyclic VLA 4 antagonists; Imidazole VLA 4 antagonists; Peptide bond mimetic; VLA 4

Indexed keywords

AMIDE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; PROTEIN INHIBITOR; SULFONE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 4 ANTAGONIST;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CHEMICAL MODIFICATION; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIGAND BINDING;

EID: 39849092416     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.045     Document Type: Article

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