Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells

Toxicology and Applied Pharmacology

Volumn 227, Issue 3, 2008, Pages 370-379

  Nicolescu, Adrian C ^a   Ji, Yanbin ^a   Comeau, Jeannette L ^a   Hill, Bruce C ^a   Takahashi, Takashi ^b   Brien, James F ^a   Racz, William J ^a   Massey, Thomas E ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amiodarone; Aryl radicals; Cytochrome c; Electron paramagnetic resonance spectroscopy; Lung epithelial cells; Mitochondria; N Desethylamiodarone; Pulmonary toxicity

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ALPHA TOCOPHEROL; AMIODARONE; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; TROLOX C;

ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; INCUBATION TIME; LUNG ALVEOLUS EPITHELIUM;

ALPHA-TOCOPHEROL; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; CELL LINE; CHROMANS; CYCLIC N-OXIDES; CYTOCHROMES C; CYTOPLASM; EPITHELIAL CELLS; HUMANS; LUNG; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; UBIQUINONE;

EID: 39849091344     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.12.009     Document Type: Article

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