메뉴 건너뛰기




Volumn 45, Issue 4, 2008, Pages 459-472

Characterization and kinetics of the major purine transporters in Aspergillus fumigatus

Author keywords

AzgA; Modelling of substrate interactions; Nucleobase; UapC

Indexed keywords

ADENINE; AMMONIA; COTRANSPORTER; FUNGAL PROTEIN; GUANINE; HYPOXANTHINE; NUCLEOTIDE TRANSPORTER; OXIPURINOL; PROTEIN AZGA; PROTEIN FUAPC; PROTEIN UAPC; PURINE; UNCLASSIFIED DRUG; URIC ACID; XANTHINE;

EID: 39749203097     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2007.08.001     Document Type: Article
Times cited : (20)

References (41)
  • 1
    • 1942487886 scopus 로고    scopus 로고
    • Transcription of purine transporter genes is activated during the isotropic growth phase of Aspergillus nidulans conidia
    • S. Amillis G. Cecchetto V. Sophianopoulou M. Koukaki C. Scazzocchio G. Diallinas Transcription of purine transporter genes is activated during the isotropic growth phase of Aspergillus nidulans conidia Mol. Microbiol. 52 2004 205 216
    • (2004) Mol. Microbiol. , vol.52 , pp. 205-216
    • Amillis, S.1    Cecchetto, G.2    Sophianopoulou, V.3    Koukaki, M.4    Scazzocchio, C.5    Diallinas, G.6
  • 2
    • 34249057464 scopus 로고    scopus 로고
    • Regulation of expression and kinetic modeling of substrate interactions of a uracil transporter in Aspergillus nidulans
    • S. Amillis Z. Hamari K. Roumelioti C. Scazzocchio G. Diallinas Regulation of expression and kinetic modeling of substrate interactions of a uracil transporter in Aspergillus nidulans Mol. Membr. Biol. 24 2007 206 214
    • (2007) Mol. Membr. Biol. , vol.24 , pp. 206-214
    • Amillis, S.1    Hamari, Z.2    Roumelioti, K.3    Scazzocchio, C.4    Diallinas, G.5
  • 3
    • 0025013201 scopus 로고
    • Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro
    • G. Andrei E. De Clercq Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro Antiviral Res. 4 1990 287 299
    • (1990) Antiviral Res. , vol.4 , pp. 287-299
    • Andrei, G.1    De Clercq, E.2
  • 4
    • 0035037254 scopus 로고    scopus 로고
    • Functional characterization of a maize purine transporter by expression in Aspergillus nidulans
    • E. Argyrou V. Sophianopoulou N. Schultes G. Diallinas Functional characterization of a maize purine transporter by expression in Aspergillus nidulans Plant Cell 13 2001 953 964
    • (2001) Plant Cell , vol.13 , pp. 953-964
    • Argyrou, E.1    Sophianopoulou, V.2    Schultes, N.3    Diallinas, G.4
  • 5
    • 0942276403 scopus 로고    scopus 로고
    • The AzgA purine transporter of Aspergillus nidulans: characterization of a protein belonging to a new phylogenetic cluster
    • G. Cecchetto S. Amillis G. Diallinas C. Scazzocchio C. Drevet The AzgA purine transporter of Aspergillus nidulans : characterization of a protein belonging to a new phylogenetic cluster J. Biol. Chem. 279 2004 3132 3141
    • (2004) J. Biol. Chem. , vol.279 , pp. 3132-3141
    • Cecchetto, G.1    Amillis, S.2    Diallinas, G.3    Scazzocchio, C.4    Drevet, C.5
  • 6
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
    • Y. Cheng W.H. Prusoff Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Biochem Pharmacol. 22 1973 3099 3108
    • (1973) Biochem Pharmacol. , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 7
    • 0014011862 scopus 로고
    • The induction and repression of nitrate reductase in the fungus Aspergillus nidulans
    • D.J. Cove The induction and repression of nitrate reductase in the fungus Aspergillus nidulans Biochim. Biophys. Acta 113 1966 51 56
    • (1966) Biochim. Biophys. Acta , vol.113 , pp. 51-56
    • Cove, D.J.1
  • 9
    • 0032732283 scopus 로고    scopus 로고
    • Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs
    • H.P. De Koning S.M. Jarvis Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs Mol. Pharmacol. 56 1999 1162 1170
    • (1999) Mol. Pharmacol. , vol.56 , pp. 1162-1170
    • De Koning, H.P.1    Jarvis, S.M.2
  • 10
    • 0031893513 scopus 로고    scopus 로고
    • Invasive aspergillosis
    • D.W. Denning Invasive aspergillosis Clin. Infect Dis. 26 1998 781 803
    • (1998) Clin. Infect Dis. , vol.26 , pp. 781-803
    • Denning, D.W.1
  • 11
    • 0028904965 scopus 로고
    • Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes
    • G. Diallinas L. Gorfinkiel H.N. Arst Jr. G. Cecchetto C. Scazzocchio Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes J. Biol. Chem. 270 1995 8610 8622
    • (1995) J. Biol. Chem. , vol.270 , pp. 8610-8622
    • Diallinas, G.1    Gorfinkiel, L.2    Arst, H.N.3    Cecchetto, G.4    Scazzocchio, C.5
  • 12
    • 0024676807 scopus 로고
    • A gene coding for the uric acid-xanthine permease of Aspergillus nidulans: inactivational cloning, characterization and sequence of a cis-acting mutation
    • G. Diallinas C. Scazzocchio A gene coding for the uric acid-xanthine permease of Aspergillus nidulans : inactivational cloning, characterization and sequence of a cis -acting mutation Genetics 122 1989 341 350
    • (1989) Genetics , vol.122 , pp. 341-350
    • Diallinas, G.1    Scazzocchio, C.2
  • 13
    • 0032528103 scopus 로고    scopus 로고
    • Chimeric purine transporters of Aspergillus nidulans define a domain critical for function and specificity conserved in bacterial, plant and metazoan homologues
    • G. Diallinas J. Valdez V. Sophianopoulou A. Rosa C. Scazzocchio Chimeric purine transporters of Aspergillus nidulans define a domain critical for function and specificity conserved in bacterial, plant and metazoan homologues EMBO J. 17 1998 3827 3837
    • (1998) EMBO J. , vol.17 , pp. 3827-3837
    • Diallinas, G.1    Valdez, J.2    Sophianopoulou, V.3    Rosa, A.4    Scazzocchio, C.5
  • 14
    • 0027490676 scopus 로고
    • Sequence and regulation of the uapA gene encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans
    • L. Gorfinkiel G. Diallinas C. Scazzocchio Sequence and regulation of the uapA gene encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans J. Biol. Chem. 268 1993 23376 23381
    • (1993) J. Biol. Chem. , vol.268 , pp. 23376-23381
    • Gorfinkiel, L.1    Diallinas, G.2    Scazzocchio, C.3
  • 15
    • 20444437463 scopus 로고    scopus 로고
    • Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family
    • S. Goudela P. Karatza M. Koukaki S. Frillingos G. Diallinas Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family Mol. Membr. Biol. 22 2005 263 275
    • (2005) Mol. Membr. Biol. , vol.22 , pp. 263-275
    • Goudela, S.1    Karatza, P.2    Koukaki, M.3    Frillingos, S.4    Diallinas, G.5
  • 16
    • 33750475581 scopus 로고    scopus 로고
    • Comparative kinetic analysis of AzgA and Fcy21p, prototypes of the two major fungal hypoxanthine–adenine–guanine transporter families
    • S. Goudela H. Tsilivi G. Diallinas Comparative kinetic analysis of AzgA and Fcy21p, prototypes of the two major fungal hypoxanthine–adenine–guanine transporter families Mol. Membr. Biol. 23 2006 291 303
    • (2006) Mol. Membr. Biol. , vol.23 , pp. 291-303
    • Goudela, S.1    Tsilivi, H.2    Diallinas, G.3
  • 17
    • 0002367719 scopus 로고
    • Optimization of PCRs
    • M.A. Innis D.H. Gelfand Optimization of PCRs M.A. Innis D.H. Gelfand J.J. Sninsky T.J. White PCR Protocols 1990 Academic Press San Diego 3 12
    • (1990) , pp. 3-12
    • Innis, M.A.1    Gelfand, D.H.2
  • 19
    • 20444448199 scopus 로고    scopus 로고
    • The Nucleobase–ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway
    • M. Koukaki A. Vlanti S. Goudela A. Pantazopoulou H. Gioule S. Tournaviti G. Diallinas The Nucleobase–ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway J. Mol. Biol. 350 2005 499 513
    • (2005) J. Mol. Biol. , vol.350 , pp. 499-513
    • Koukaki, M.1    Vlanti, A.2    Goudela, S.3    Pantazopoulou, A.4    Gioule, H.5    Tournaviti, S.6    Diallinas, G.7
  • 20
    • 30944467252 scopus 로고    scopus 로고
    • Gene targeting in Aspergillus fumigatus by homologous recombination is facilitated in a nonhomologous end-joining-deficient genetic background
    • S. Krappmann C. Sasse G.H. Braus Gene targeting in Aspergillus fumigatus by homologous recombination is facilitated in a nonhomologous end-joining-deficient genetic background Eukaryot Cell 5 2006 212 215
    • (2006) Eukaryot Cell , vol.5 , pp. 212-215
    • Krappmann, S.1    Sasse, C.2    Braus, G.H.3
  • 21
    • 0029119354 scopus 로고
    • Membrane transport of nucleobases: interaction with inhibitors
    • M. Kraupp R. Marz Membrane transport of nucleobases: interaction with inhibitors Gen. Pharmacol. 26 1995 1185 1190
    • (1995) Gen. Pharmacol. , vol.26 , pp. 1185-1190
    • Kraupp, M.1    Marz, R.2
  • 22
    • 0032916340 scopus 로고    scopus 로고
    • Aspergillus fumigatus and aspergillosis
    • J.P. Latge Aspergillus fumigatus and aspergillosis Clin. Microbiol. Rev. 12 2 1999 310 350
    • (1999) Clin. Microbiol. Rev. , vol.12 , Issue.2 , pp. 310-350
    • Latge, J.P.1
  • 23
    • 0034105567 scopus 로고    scopus 로고
    • Amino acid residues N450 and Q449 are critical for the uptake capacity and specificity of UapA, a prototype of a nucleobase-ascorbate transporter family
    • C. Meintanis A.D. Karagouni G. Diallinas Amino acid residues N450 and Q449 are critical for the uptake capacity and specificity of UapA, a prototype of a nucleobase-ascorbate transporter family Mol. Membr. Biol. 17 2000 47 57
    • (2000) Mol. Membr. Biol. , vol.17 , pp. 47-57
    • Meintanis, C.1    Karagouni, A.D.2    Diallinas, G.3
  • 26
    • 85120142465 scopus 로고    scopus 로고
    • Pantazopoulou, A., Diallinas, G., in press. Fungal nucleobase transporters. FEMS Microbiol. Rev.
  • 27
    • 33750485340 scopus 로고    scopus 로고
    • The first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transport
    • A. Pantazopoulou G. Diallinas The first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transport Mol. Membr. Biol. 23 2006 337 348
    • (2006) Mol. Membr. Biol. , vol.23 , pp. 337-348
    • Pantazopoulou, A.1    Diallinas, G.2
  • 28
    • 15944376513 scopus 로고    scopus 로고
    • Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues
    • I.G. Papageorgiou L. Yakob M.I. Al Salabi G. Diallinas K.P. Soteriadou H.P. De Koning Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues Parasitology 130 2005 275 283
    • (2005) Parasitology , vol.130 , pp. 275-283
    • Papageorgiou, I.G.1    Yakob, L.2    Al Salabi, M.I.3    Diallinas, G.4    Soteriadou, K.P.5    De Koning, H.P.6
  • 29
    • 0002145440 scopus 로고
    • Isolation of protease negative mutants of Aspergillus fumigatus by insertion of a disrupted gene
    • S. Paris Isolation of protease negative mutants of Aspergillus fumigatus by insertion of a disrupted gene B. Maresca G.S. Kobayashi Molecular Biology of Pathogenic fungi. A Laboratory Manual 1994 Telos Press New York 49 55
    • (1994) , pp. 49-55
    • Paris, S.1
  • 30
    • 0025052576 scopus 로고
    • Functional elements in the promoter region of the Aspergillus nidulans gpdA gene encoding glyceraldehyde-3-phosphate dehydrogenase
    • P.J. Punt M.A. Dingemanse A. Kuyvenhoven R.D. Soede P.H. Pouwels C.A. van den Hondel Functional elements in the promoter region of the Aspergillus nidulans gpdA gene encoding glyceraldehyde-3-phosphate dehydrogenase Gene 93 1990 101 109
    • (1990) Gene , vol.93 , pp. 101-109
    • Punt, P.J.1    Dingemanse, M.A.2    Kuyvenhoven, A.3    Soede, R.D.4    Pouwels, P.H.5    van den Hondel, C.A.6
  • 31
    • 0004136246 scopus 로고    scopus 로고
    • Molecular cloning: A Laboratory Manual
    • J. Sambrook E.F. Fritisch T. Maniatis Molecular cloning: A Laboratory Manual 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
    • (1989)
    • Sambrook, J.1    Fritisch, E.F.2    Maniatis, T.3
  • 32
    • 0004136246 scopus 로고    scopus 로고
    • Molecular Cloning: A Laboratory Manual
    • J. Sambrook D.W. Russel Molecular Cloning: A Laboratory Manual 2001 Cold Spring Harbor New York
    • (2001)
    • Sambrook, J.1    Russel, D.W.2
  • 34
    • 0020096447 scopus 로고
    • Positive regulation in a eukaryote, a study of the uaY gene of Aspergillus nidulans: characterization of alleles, dominance and complementation studies, and a fine structure map of the uaY-oxpA cluster
    • C. Scazzocchio N. Sdrin G. Ong Positive regulation in a eukaryote, a study of the uaY gene of Aspergillus nidulans : characterization of alleles, dominance and complementation studies, and a fine structure map of the uaY-oxpA cluster Genetics 100 1982 185 208
    • (1982) Genetics , vol.100 , pp. 185-208
    • Scazzocchio, C.1    Sdrin, N.2    Ong, G.3
  • 35
    • 0023917192 scopus 로고
    • Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro
    • S. Shigeta K. Konno T. Yokota K. Nakamura E. De Clercq Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro Antimicrob. Agents Chemother. 32 1988 906 911
    • (1988) Antimicrob. Agents Chemother. , vol.32 , pp. 906-911
    • Shigeta, S.1    Konno, K.2    Yokota, T.3    Nakamura, K.4    De Clercq, E.5
  • 36
    • 0019211743 scopus 로고
    • A notable Aspergillus from a mortal aspergilloma of the lung. New aspects of the epidemiology, serodiagnosis and taxonomy of Aspergillus fumigatus
    • F. Staib S.K. Mishra C. Rajendran R. Voigt J. Steffen K.H. Neumann C.A. Hartmann G. Heins A notable Aspergillus from a mortal aspergilloma of the lung. New aspects of the epidemiology, serodiagnosis and taxonomy of Aspergillus fumigatus Zentralbl Bakteriol [A] 247 1980 530 536
    • (1980) Zentralbl Bakteriol [A] , vol.247 , pp. 530-536
    • Staib, F.1    Mishra, S.K.2    Rajendran, C.3    Voigt, R.4    Steffen, J.5    Neumann, K.H.6    Hartmann, C.A.7    Heins, G.8
  • 37
    • 0028949626 scopus 로고
    • The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae
    • T. Suarez M.V. de Queiroz N. Oestreicher C. Scazzocchio The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans , suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae EMBO J. 14 1995 1453 1467
    • (1995) EMBO J. , vol.14 , pp. 1453-1467
    • Suarez, T.1    de Queiroz, M.V.2    Oestreicher, N.3    Scazzocchio, C.4
  • 39
    • 0033869563 scopus 로고    scopus 로고
    • Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
    • A. Vermes H.J. Guchelaar J. Dankert Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions J. Antimicrob. Chemother. 46 2000 171 179
    • (2000) J. Antimicrob. Chemother. , vol.46 , pp. 171-179
    • Vermes, A.1    Guchelaar, H.J.2    Dankert, J.3
  • 40
    • 33644947026 scopus 로고    scopus 로고
    • A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter
    • A. Vlanti S. Amillis M. Koukaki G. Diallinas A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter J. Mol. Biol. 357 2006 808 819
    • (2006) J. Mol. Biol. , vol.357 , pp. 808-819
    • Vlanti, A.1    Amillis, S.2    Koukaki, M.3    Diallinas, G.4
  • 41
    • 0037135609 scopus 로고    scopus 로고
    • Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites
    • L.J. Wallace D. Candlish H.P. De Koning Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites J. Biol. Chem. 27729 2002 26149 26156
    • (2002) J. Biol. Chem. , vol.27729 , pp. 26149-26156
    • Wallace, L.J.1    Candlish, D.2    De Koning, H.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.