The fungal GATA factors

Current Opinion in Microbiology

Volumn 3, Issue 2, 2000, Pages 126-131

  Scazzocchio, Claudio ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1;

ASCOMYCETES; BINDING SITE; CHROMATIN STRUCTURE; DNA BINDING; DNA PROTEIN COMPLEX; FUNGAL GENETICS; GENETIC TRANSCRIPTION; HYDROPHOBICITY; NONHUMAN; PHYLOGENY; REVIEW; TRANSCRIPTION REGULATION;

ASCOMYCOTA; EUKARYOTA;

EID: 0034125472     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00063-1     Document Type: Review

References (52)

1. Merika M., Orkin S.H. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol. 13:1993;3999-4010.
2. Ko L.J., Engel J.D. DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol. 13:1993;4011-4022.
3. Ravagnani A., Gorfinkiel L., Langdon T., Diallinas G., Adjaji E., Demais S., Gorton D., Arst H.N. Jr., Scazzocchio C. Subtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA. EMBO J. 16:1997;3974-3986.
4. Yang H.Y., Todd E. Distinct roles for the two cGATA-1 finger domains. Mol Cell Biol. 12:1992;4562-4570.
5. Fox A.H., Kowalski K., King G.F., Mackay J.P., Crossley M. Key residues characteristic of GATA N-fingers are recognized by FOG. J Biol Chem. 273:1998;33595-33603.
6. Ballario P., Vittorioso P., Magrelli A., Talora C., Cabibbo A., Macino G. White collar-1, a central regulator of blue light responses in Neurospora, is a zinc finger protein. EMBO J. 15:1996;1650-1657.
7. Chang W.T., Newell P.C., Gross J.D. Identification of the cell fate gene stalky in Dictyostelium. Cell. 87:1996;471-481.
8. Teackle G.R., Gilmartin P.M. Two forms of type IV zinc-finger motif and their kingdom-specific distribution between the flora, fauna and fungi. Trends Biochem Sci. 23:1998;100-102. The natural history and evolutionary relationship of GATA-binding motifs are described in this review.
9. Omichinski J.G., Clore G.M., Schaad O., Felsenfeld G., Trainor C., Appella E., Stahl S.J., Gronenborn A.M. NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science. 261:1993;438-446.
10. Starich M.R., Wikström M., Arst H.N. Jr., Clore G.M., Gronenborn A.M. The solution structure of a fungal AREA protein-DNA complex: an alternative binding mode for the basic carboxyl tail of GATA factors. J Mol Biol. 277:1998;605-620. Gronenborn and co-workers [9] pushed NMR to the limits of its resolutions, and presented the structure of the chicken GATA1-DNA complex. Here the same group continues the story and presents the structure of the fungal AreA-DNA complex.
11. Orkin S.H. GATA-Binding transcription factors in hematopoietic cells. Blood. 80:1992;575-581.
12. Tsai F.Y., Browne C.P., Orkin S.H. Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev Biol. 15:1998;218-227. A recent article by the group of one of the leaders in the field of mammalian GATA factors [1,11].
13. Gao X., Sedgwick T., Shi Y.B., Evans T. Distinct functions are implicated for the GATA-4,-5 and-6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol. 18:1998;2901-2911.
14. Charron F., Paradis P., Bronchain O., Nemer G., Nemer M. Co-operative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Mol Cell Biol. 19:1999;4355-4365.
15. Zhu J., Hill R.J., Heid P.J., Fukuyama M., Sugimoto A., Priess J.R., Rothman J.H. end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos. Genes Dev. 11:1997;2883-2896.
16. Petersen U.M., Kadalayil L., Rehorn K.P., Hoshizaki D.K., Reuter R., Engstrom Y. Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif. EMBO J. 18:1999;4013-4022.
17. Lossky M., Wensink P.C. Regulation of Drosophila yolk protein genes by an ovary-specific GATA factor. Mol Cell Biol. 15:1995;6943-6952.
18. Haenlin M., Cubadda Y., Blondeau F., Heitzler P., Lutz Y., Simpson P., Ramain P. Transcriptional activity of Pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. Genes Dev. 11:1997;3096-3108.
19. Rastogi R., Bate N.J., Sivasankar S., Rothstein S.J. Footprinting of the spinach nitrite reductase gene promoter reveals the preservation of nitrate regulatory elements between fungi and higher plants. Plant Mol Biol. 34:1997;465-476.
20. Arst H.N. Jr., Cove D.J. Nitrogen metabolite repression in Aspergilus nidulans. Mol Gen Genet. 126:1973;111-141.
21. Muro-Pastor M.I., Strauss J., González R., Scazzocchio C. The GATA factor AreA is essential for chromatin remodelling in an eucaryotic bidirectional promoter. EMBO J. 18:1999;1584-1597. The authors summarise the control of the niiA-niaD (nitrite and nitrate reductase) bidirectional promoter and establish its nucleosome structure. They determine that drastic chromatin rearrangement found under expression conditions is independent of transcription and of the specific factor NirA, but is strictly dependent on the GATA factor AreA.
22. Marzluf G.A. Genetic regulation of nitrogen metabolism in the fungi. Microbiol Mol Biol Rev. 61:1997;17-32.
23. Xiao X., Fu Y.-H., Marzluf G.A. The negative-acting NMR regulatory protein of Neurospora crassa binds to and inhibits the DNA-binding activity of the positive-acting nitrogen regulatory protein NIT2. Biochem. 34:1995;8861-8868.
24. Platt A., Langdon T., Arst H.N. Jr., Kirk D., Tollervey D., Mates Sanchez J.M., Caddick M.X. Nitrogen metabolite signalling involves the C-terminus and the GATA domain of the Aspergillus transcription factor AREA and the 3′ untranslated region of its mRNA. EMBO J. 15:1996;2791-2801.
25. Andrianopoulos A., Kourambas S., Sharp J.A., Davis M.A., Hynes M.J. Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression. J Bacteriol. 180:1998;1973-1977.
26. Amrani L., Cecchetto G., Scazzocchio C., Glatigny A. The hxB gene, necessary for the post-translational activation of purine hydroxylases in Aspergillus nidulans, is independently controlled by the purine utilization and the nicotinate utilization transcriptional activating systems. Mol Microbiol. 31:1999;1065-1073.
27. Soussi-Boudekou S., Vissers S., Urrestarazu A., Jauniaux J.-C., André B. Gzf3p, a fourth GATA factor involved in nitrogen-regulated transcription in Saccharomyces cerevisiae. Mol Microbiol. 23:1997;1157-1168.
28. Coffman J.A., Rai R., Loprete D.M., Cunningham T., Svetlov V., Cooper T.G. Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J Bacteriol. 179:1997;3416-3429.
29. Svetlov V.V., Cooper T.G. The Saccharomyces cerevisiae GATA factors Dal80p and Deh1p can form homo- and heterodimeric complexes. J Bacteriol. 180:1998;5682-5688. There are a plethora of articles on the interactions of the four yeast GATA factors involved in nitrogen metabolite repression, by this and other groups (B André and B Magasanik, see [27,28]), I have chosen somewhat arbitrarily this one as recommended reading.
30. Tollervey D.W., Arst H.N. Jr. Domain-wide, locus-specific suppression of nitrogen metabolite repressed mutations in Aspergillus, nidulans. Curr, Genet. 6:1982;79-85.
31. Scazzocchio C., Gavrias V., Cubero B., Panozzo C., Mathieu M., Felenbok B. Carbon catabolite repression in Aspergillus nidulans, a review. Can J Botany. 73:1995;S160-S166.
32. Luftiyya L.L., Johnston M. Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol Cell Biol. 16:1996;4790-4797.
33. Voisard C., Wang J., McEvoy J.L., Xu P., Leong S.A. urbs1, a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid transcription factor GATA-1. Mol Cell Biol. 13:1993;7091-7100.
34. An Z., Mei B., Yuan W.M., Leong S.A. The distal GATA sequences of the sid1 promoter of Ustilago maydis mediate iron repression of the siderophore production and interact directly with Urbs1, a GATA family transcription factor. EMBO J. 16:1997;1742-1750.
35. An Z., Zhao Q., McEvoy J., Yuan W.M., Markley J.L., Leong S.A. The second finger of Urbs1 is required for iron-mediated repression of sid1 in Ustilago maydis. Proc Natl Acad Sci USA. 94:1997;5882-5887.
36. Haas H., Zadra I., Stoffler G., Angermayr K. The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J Biol Chem. 274:1999;4613-4619. The work of Leong and co-workers [33-35] established that key regulator of siderophore biosynthesis in a basidiomycete is a two-fingered GATA factor. This article extends the work to a model ascomycete.
37. Linden H., Macino G. White collar 2, a partner in blue-light signal transduction, controlling expression of light-regulated genes in Neurospora crassa. EMBO J. 16:1997;98-109.
38. Ballario P., Macino G. White collar proteins: PASsing the light signal in Neurospora crassa. Trends Microbiol. 5:1997;458-462.
39. Talora C., Franchi L., Linden H., Ballario P., Macino G. Role of a white collar-1-white collar-2 complex in blue-light signal transduction. EMBO J. 18:1999;4961-4968. The authors demonstrate the phosphorylation and turnover of WC1 and propose specific roles for a WC1/WC2 heterodimer.
40. Sil A., Herskowitz I. Identification of asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene. Cell. 84:1996;711-722.
41. Long R.M., Singer R.H., Meng X., Gonzalez I., Nasmyth K., Jansen R.P. Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA. Science. 277:1997;383-387.
42. ••]. Together they describe the establishment of a factor involved in mother/daughter cell asymmetry, and the establishment of the mechanism of mRNA localisation by association with a myosin molecule.
43. Kudla B., Caddick M.X., Langdon T., Martinez-Rossi N.M., Bennett C.F., Sibley S., Davies R.W., Arst H.N. Jr. The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus, nidulans. Mutations, affecting specific gene activation alter a loop residue of a putative zinc finger. EMBO J. 9:1990;1355-1364.
44. ••] is perhaps the most thorough mutational study ever of a DNA-binding domain. Perhaps, one day, structural and/or modelling studies will tell us why each mutant is a mutant and how second site revertants act.
45. Starich M.R., Wikström M., Schumacher S., Arst H.N. Jr., Gronenborn A.M., Clore G.M. The solution structure of the Leu22→Val mutant AREA DNA binding domain complexed with a TGATAG core element defines a role for hydrophobic packing in the determination of specificity. J Mol Biol. 277:1998;621-634. Ravagnani et al. [3] proposed a model for specificity recognition, this work establishes the real structures underlying the specificity of the conserved leucine of the loop.
46. Mackay J.P., Crossley M. Zinc fingers are sticking together. Trends Biochem Sci. 23:1998;1-4. A good review on the protein-protein interactions of Zn fingers, including GATA factors.
47. Feng B., Marzluf G.A. Interaction between major nitrogen regulatory protein NIT2 and pathway-specific regulatory factor NIT4 is required for their synergistic activation of gene expression in Neurospora crassa. Mol Cell Biol. 18:1998;3983-3990. This, and [23] by the same group illustrate (in vitro) the potential for protein-protein interaction of the single NIT2 GATA-binding domain. Given the sequence identity, this work can be extended to AreA and other fungal homologous regulators, but probably not to those of S. cerevisiae.
48. Stamatoyannopoulos J.A., Goodwin A., Joyce T., Lowrey C.H. NF-E2 and GATA binding motifs are required for the formation of Dnase I hypersensitive site 4 of the human β-globin locus control region. EMBO J. 14:1995;106-116.
49. Boyes J., Felsenfeld G. Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site. EMBO J. 15:1996;2496-2507.
50. Boyes J., Omichinski J., Clark D., Pikaart M., Felsenfeld G. Perturbation of nucleosome structure by the erythroid transcription factor GATA-1. J Mol Biol. 279:1998;529-544. This, together with [48,49], establishes the involvement of GATA1 in chromatin re-arrangements in mammalian promoters.
51. •].
52. •] of a coming flood showing that GATA factors are acetylated and disagreeing on the effect of acetylation on DNA binding.