Fed-batch mode in shake flasks by slow-release technique

Biotechnology and Bioengineering

Volumn 95, Issue 3, 2006, Pages 433-445

  Jeude, M ^a   Dittrich, B ^a   Niederschulte, H ^a   Anderlei, T ^b   Knocke, C ^a,c   Klee, D ^a   Buchs J ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b AC Biotec GmbH   (Germany)

^c DASGIP AG   (Germany)

Author keywords

Catabolite repression; Fed batch; Green fluorescent protein (GFP); Hansenula polymorpha; High cell density cultivation (HCDC); Overflow metabolism; Shake flask; Slow release

Indexed keywords

DIFFUSION; FLUORESCENCE; GLUCOSE; MICROBIOLOGY; PHYSIOLOGY; PROTEINS;

CATABOLITE REPRESSION; FED-BATCH; GREEN FLUORESCENT PROTEIN (GFP); HANSENULA POLYMORPHA; HIGH CELL DENSITY CULTIVATION (HCDC); SHAKE FLASK; SLOW-RELEASE;

BATCH CELL CULTURE;

ACETIC ACID; ALCOHOL; ELASTOMER; GLUCOSE; GREEN FLUORESCENT PROTEIN; SILICON;

ARTICLE; CELL DENSITY; COMPUTER SYSTEM; CONTROLLED STUDY; FED BATCH CULTURE; FED BATCH FERMENTATION; FUNGAL BIOMASS; FUNGUS GROWTH; GLUCOSE METABOLISM; HANSENULA POLYMORPHA; NONHUMAN; RESPIRATORY QUOTIENT;

BIOMASS; BIOREACTORS; CULTURE MEDIA; FERMENTATION; GLUCOSE; INDUSTRIAL MICROBIOLOGY; KINETICS; PICHIA;

PICHIA ANGUSTA;

EID: 33749347886     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21012     Document Type: Article

References (64)

1. Albers E, Larsson C, Liden G, Niklasson C, Gustafsson L. 1996. Influence of the nitrogen source on Saccharomyces cerevisiae anaerobic growth and product formation. Appl Environ Microbiol 62(9):3187-3195.
2. Amsden B. 2003. A model for osmotic pressure driven release from cylindrical rubbery polymer matrices. J Control Release 93(3):249-258.
3. Amuel C, Gellissen G, Hollenberg CP, Suckow M. 2000. Analysis of heat shock promoters in Hansenula polymorpha: The TPS1 promoter, a novel element for heterologous gene expression. Biotechnol Bioprocess Eng 5:247-252.
4. Anderlei T, Büchs J. 2001. Device for sterile online measurement of the oxygen transfer rate in shaking flasks. Biochem Eng J 7(2):157-162.
5. Anderlei T, Zang W, Papaspyrou M, Büchs J. 2004. Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochem Eng J 17(3):187-194.
6. Atkinson B, Mavituna F. 1983. Biochemical Engineering and Biotechnology Handbook. Surrey, England: Macmillan Publishers Ltd., p 120.
7. Baker R. 1987. Controlled release of biologically active agents. New York: John Wiley & Sons, pp 1-280.
8. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
9. Browning DF, Grainger DC, Beatty CM, Wolfe AJ, Cole JA, Busby SJW. 2005. Integration of three signals at the Escherichia coli nrf promoter: A role for Fis protein in catabolite repression. Mol Microbiol 57(2):496-510.
10. Büchs J. 2001. Introduction to advantages and problems of shaken cultures. Biochem Eng J 7(2):91-98.
11. Büchs J. 2004. Biochemical engineering journal-preface. Biochem Eng J 17(3):153-153.
12. Carelli V, Dicolo G, Guerrini C, Nannipieri E. 1989. Drug release from silicone elastomer through controlled polymer cracking-an extension to macromolecular drugs. Int J Pharm 50(3):181-188.
13. Chang WJ, Akin D, Sedlak M, Ladisch MR, Bashir R. 2003. Poly(- dimethylsiloxane) (PDMS) and silicone hybrid biochip for bacterial culture. Biomedical Microdevices 5(4):281-290.
14. Clark GJ, Langley D, Bushell ME. 1995. Oxygen limitation can induce microbial secondary metabolite formation-investigations with miniature electrodes in shaker and bioreactor culture. Microbiology-UK 141:663-669.
15. Danielson PB, Büchs J, Stöckmann C, Fogleman JC. 2004. Maximizing cell densities in miniprep-scale cultures with H15 medium and improved oxygen transfer. Biochem Eng J 17(3):175-180.
16. Di Colo G. 1992. Controlled drug release from implantable matrices based on hydrophobic polymers. Biomaterials 13(12):850-856.
17. Faber KN, Westra S, Waterham HR, KeizerGunnink I, Harder W, Ab G, Veenhuis M. 1996. Foreign gene expression in Hansenula polymorpha. A system for the synthesis of small functional peptides. Appl Microbiol Biotechnol 45(1-2):72-79.
18. Gellissen G. 2000. Heterologous protein production in methylotrophic yeasts. Appl Microbiol Biotechnol 54(6):741-750.
19. Gellissen G. 2004. Production of recombinant proteins. Weinheim: Wiley-VCH-Verlag GmbH.
20. Hansen H, Hollenberg CP. 1996. Non-conventional yeasts in biotechnology. A handbook. Heidelberg: Springer.
21. Hermann R, Walther N, Maier U, Buchs J. 2001. Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation. Biotechnol Bioeng 74(5):355-363.
22. Higuchi T. 1961. Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci 50(10):874-875.
23. Higuchi T. 1963. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 52:1145-1149.
24. Hollenberg CP, Gellissen G. 1997. Production of recombinant proteins by methylotrophic yeasts. Curr Opin Biotechnol 8(5):554-560.
25. Hsieh DST, Rhine WD, Langer R. 1983. Zero-order controlled-release polymer matrices for micromolecules and macromolecules. J Pharm Sci 72(1):17-22.
26. Humphrey A. 1998. Shake flask to fermentor: What have we learned? Biotechnol Prog 14(1):3-7.
27. Kajihara M, Sugie T, Mizuno M, Tamura N, Sano A, Fujioka K, Kashiwazaki Y, Yamaoka T, Sugawara S, Urabe Y. 2000. Development of new drug delivery system for protein drugs using silicone (I). J Control Release 66(1):49-61.
28. Kennedy MJ, Reader SL, Davies RJ, Rhoades DA, Silby HW. 1994. The scale-up of mycelial shake flask fermentations-a case-study of gamma-linolenic acid production by Mucor hiemalis Irl-51. J Ind Microbiol 13(4):212-216.
29. Kim BS, Lee SC, Lee SY, Chang YK, Chang HN. 2004. High cell density fed-batch cultivation of Escherichia coli using exponential feeding combined with pH-stat. Bioprocess Biosyst Eng 26(3):147-150.
30. Klinke HB, Thomsen AB, Ahring BK. 2004. Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pretreatment of biomass. Appl Microbiol Biotechnol 66(1):10-26.
31. Kost J, Langer R. 2001. Responsive polymeric delivery systems. Adv Drug Deliv Rev 46(1-3):125-148.
32. Kramarenko T, Karp H, Jarviste A, Alamae T. 2000. Sugar repression in the methylotrophic yeast Hansenula polymorpha studied by using hexokinase-negative, glucokinase-negative and double kinase-negative mutants. Folia Microbiologica 45(6):521-529.
33. Kumar S, Wittmann C, Heinzle E. 2004. Minibioreactors. Biotechnol Lett 26(1):1-10.
34. Langer R. 1980. Polymeric delivery systems for controlled drug release. Chem Eng Commun 6(1-3):1-48.
35. Langer R. 1990. New methods of drug delivery. Science 249(4976):1527-1533.
36. Langer R, Folkman J. 1976. Polymers for the sustained release of proteins and other macromolecules. Nature 263(5580):797-800.
37. Langer RS, Peppas NA. 1981. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 2(4):201-214.
38. Langer R, Fefferman M, Gryska P, Bergman K. 1980. Simple method for studying chemotaxis using sustained-release of attractants from inert polymers. Can J Microbiol 26(2):274-278.
39. Larsson G, Jorgensen SB, Pons MN, Sonnleitner B, Tijsterman A, Titchener-Hooker N. 1997. Biochemical engineering science. J Biotechnol 59(1-2):3-9.
40. Losen M, Frolich B, Pohl M, Buchs J. 2004. Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures. Biotechnol Prog 20(4):1062-1068.
41. Lotter S, Büchs J. 2004. Utilization of specific power input measurements for optimization of culture conditions in shaking flasks. Biochem Eng J 17(3):195-203.
42. Lübbe C, Demain AL, Bergman K. 1985. Use of controlled-release polymer to feed ammonium to Streptomyces clavuligerus cephalosporin fermentations in shake flasks. Appl Microbiol Biotechnol 22:424-427.
43. Maier U, Losen M, Büchs J. 2004. Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochem Eng J 17(3):155-167.
44. Mayer AF, Hellmuth K, Schlieker H, Lopez-Ulibarri R, Oertel S, Dahlems U, Strasser AWM, van Loon APGM. 1999. An expression system matures: A highly efficient and cost-effective process for phytase production by recombinant strains of Hansenula polymorpha. Biotechnol Bioeng 63(3):373-381.
45. McGinity JW, Hunke LA, Combs AB. 1979. Effect of water-soluble carriers on morphine sulfate release from a silicone polymer. J Pharm Sci 68(5):662-664.
46. Narasimhan B, Langer R. 1997. Zero-order release of micro- and macromolecules from polymeric devices: The role of the burst effect. J Control Release 47(1):13-20.
47. Peter CP, Lotter S, Maier U, Büchs J. 2004. Impact of out-of-phase conditions on screening results in shaking flask experiments. Biochem Eng J 17(3):205-215.
48. Raval KN, Hellwig S, Prakash G, Ramos-Plasencia A, Srivastava A, Büchs J. 2003. Necessity of a two-stage process for the production of azadirachtin-related limonoids in suspension cultures of Azadirachta indica. J Biosci Bioeng 96(1):16-22.
49. Rheinwald J, Green H. 1974. Growth of cultured mammalian cells on secondary glucose sources. Cell 2(4):287-293.
50. Riesenberg D. 1991. High-cell-density cultivation of Escherichia coli. Curr Opin Biotechnol 2(3):380-384.
51. Riesenberg D, Guthke R. 1999. High-cell-density cultivation of microorganisms. Appl Microbiol Biotechnol 51(4):422-430.
52. Schirrer R, Thepin P, Torres G. 1992. Water-absorption, swelling, rupture and salt release in salt silicone-rubber compounds. J Mater Sci 27(13):3424-3434.
53. Silberbach M, Maier B, Zimmermann M, Büchs J. 2003. Glucose oxidation by Gluconobacter oxydans: Characterization in shaking-flasks, scale-up and optimization of the pH profile. Appl Microbiol Biotechnol 62(1):92-98.
54. Sonnleitner B, Käppeli O. 1986. Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: Formulation and verification of a hypothesis. Biotechnol Bioeng 28(6):927-937.
55. Stasyk OV, Stasyk OG, Komduur J, Veenhuis M, Cregg JM, Sibirny AA. 2004. A hexose transporter homologue controls glucose repression in the methylotrophic yeast Hansenula polymorpha. J Biol Chem 279(9):8116-8125.
56. Stöckmann C, Losen M, Dahlems U, Knocke C, Gellissen G, Büchs J. 2003a. Effect of oxygen supply on passaging, stabilising and screening of recombinant Hansenula polymorpha production strains in test tube cultures. FEMS Yeast Res 4(2):195-205.
57. Stöckmann C, Maier U, Anderlei T, Knocke C, Gellissen G, Büchs J. 2003b. The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures. J Ind Microbiol Biotechnol 30(10):613-622.
58. Suckow M, Gellissen G. 2002. Hansenula polymorpha-biology and applications. Weinheim: Wiley-VCH Verlag GmbH.
59. Suzuki S, Taketani H, Kusumoto K, Kashiwagi Y. 2003. High-throughput screening for isolation of enhanced green fluorescent protein expressing transformants of filamentous fungus using an image analyzer. J Biosci Bioeng 96(3):313-316.
60. van Wijk R. 1968. Alpha-glucosidase synthesis, respiratory enzymes and catabolite repression in yeast. I. The effects of glucose and maltose on inducible alpha-glucosidase synthesis in protoplasts of S. carlsbergensis. Proc K Ned Akad Wet C 71(1):60-71.
61. Weuster-Botz D, Altenbach-Rehm J, Arnold M. 2001. Parallel substrate feeding and pH-control in shaking-flasks. Biochem Eng J 7(2):163-170.
62. Weydemann U, Keup P, Piontek M, Strasser AW, Schweden J, Gellissen G, Janowicz ZA. 1995. High-level secretion of hirudin by Hansenula polymorpha-authentic processing of three different preprohirudins. Appl Microbiol Biotechnol 44(3-4):377-385.
63. Wittmann C, Zeng AP, Deckwer WD. 1995. Growth inhibition by ammonia and use of a pH-controlled feeding strategy for the effective cultivation of Mycobacterium chlorophenolicum. Appl Microbiol Biotechnol 44(3-4):519-525.
64. Xu B, Jahic M, Blomsten G, Enfors SO. 1999. Glucose overflow metabolism and mixed-acid fermentation in aerobic large-scale fed-batch processes with Escherichia coli. Appl Microbiol Biotechnol 51(5):564-571.