R-peptide cleavage potentiates fusion-controlling isomerization of the intersubunit disulfide in moloney murine leukemia virus Env

Journal of Virology

Volumn 82, Issue 5, 2008, Pages 2594-2597

  Löving, Robin ^a   Li, Kejun ^a   Wallin, Michael ^a   Sjöberg, Mathilda ^a   Garoff, Henrik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; HYBRID PROTEIN; PEPTIDE DERIVATIVE; PROTEIN SUBUNIT; R PEPTIDE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ISOMERIZATION; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; VIRUS ENVELOPE; VIRUS INACTIVATION; VIRUS INHIBITION; VIRUS MUTANT;

ANIMALS; DISULFIDES; GENE PRODUCTS, ENV; HYDROLYSIS; ISOMERISM; MEMBRANE FUSION; MOLONEY MURINE LEUKEMIA VIRUS; MUTATION; NEOPLASM PROTEINS; PEPTIDES;

MOLONEY MURINE LEUKEMIA VIRUS; MURINE LEUKEMIA VIRUS;

EID: 39749162175     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02039-07     Document Type: Article

References (23)

1. Aguilar, H. C., W. F. Anderson, and P. M. Cannon. 2003. Cytoplasmic tail of Moloney murine leukemia virus envelope protein influences the conformation of the extracellular domain: implications for mechanism of action of the R peptide. J. Virol. 77:1281-1291.
2. Bobkova, M., J. Stitz, M. Engelstadter, K. Cichutek, and C. J. Buchholz. 2002. Identification of R-peptides in envelope proteins of C-type retroviruses. J. Gen. Virol. 83:2241-2246.
3. Brody, B. A., S. S. Rhee, and E. Hunter. 1994. Postassembly cleavage of a retroviral glycoprotein cytoplasmic domain removes a necessary incorporation signal and activates fusion activity. J. Virol. 68:4620-4627.
4. Colicelli, J., and S. P. Goff. 1988. Sequence and spacing requirements of a retrovirus integration site. J. Mol. Biol. 199:47-59.
5. Green, N., T. M. Shinnick, O. Witte, A. Ponticelli, J. G. Sutcliffe, and R. A. Lerner. 1981. Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc. Natl. Acad. Sci. USA 78:6023-6027.
6. Henderson, L. E., R. Sowder, T. D. Copeland, G. Smythers, and S. Oroszlan. 1984. Quantitative separation of murine leukemia virus proteins by reversed-phase high-pressure liquid chromatography reveals newly described gag and env cleavage products. J. Virol. 52:492-500.
7. Januszeski, M. M., P. M. Cannon, D. Chen, Y. Rozenberg, and W. F. Anderson. 1997. Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein. J. Virol. 71:3613-3619.
8. Kubo, Y., and H. Amanuma. 2003. Mutational analysis of the R peptide cleavage site of Moloney murine leukaemia virus envelope protein. J. Gen. Virol. 84:2253-2257.
9. Li, K., S. Zhang, M. Kronqvist, M. Ekström, M. Wallin, and H. Garoff. 2007. The conserved His8 of the Moloney murine leukemia virus Env SU subunit directs the activity of the SU-TM disulphide bond isomerase. Virology 361: 149-160.
10. Li, M., Z. N. Li, Q. Yao, C. Yang, D. A. Steinhauer, and R. W. Compans. 2006. Murine leukemia virus R peptide inhibits influenza virus hemagglutinin-induced membrane fusion. J. Virol. 80:6106-6114.
11. Li, M., C. Yang, and R. W. Compans. 2001. Mutations in the cytoplasmic tail of murine leukemia virus envelope protein suppress fusion inhibition by R peptide. J. Virol. 75:2337-2344.
12. Melikyan, G. B., R. M. Markosyan, S. A. Brener, Y. Rozenberg, and F. S. Cohen. 2000. Role of the cytoplasmic tail of ecotropic Moloney murine leukemia virus Env protein in fusion pore formation. J. Virol. 74:447-455.
13. Opstelten, D.-J., M. Wallin, and H. Garoff. 1998. Moloney murine leukemia virus envelope protein subunits, gp70 and Pr15E, form a stable disulfide-linked complex. J. Virol. 72:6537-6545.
14. Pinter, A., R. Kopelman, Z. Li, S. C. Kayman, and D. A. Sanders. 1997. Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes. J. Virol. 71:8073-8077.
15. Ragheb, J. A., and W. F. Anderson. 1994. pH-independent murine leukemia virus ecotropic envelope-mediated cell fusion: implications for the role of the R peptide and p12E TM in viral entry. J. Virol. 68:3220-3231.
16. Rein, A., J. Mirro, J. G. Haynes, S. M. Ernst, and K. Nagashima. 1994. Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein. J. Virol. 68:1773-1781.
17. Schultz, A., and A. Rein. 1985. Maturation of murine leukemia virus env proteins in the absence of other viral proteins. Virology 145:335-339.
18. Taylor, G. M., and D. A. Sanders. 2003. Structural criteria for regulation of membrane fusion and virion incorporation by the murine leukemia virus TM cytoplasmic domain. Virology 312:295-305.
19. Wallin, M., M. Ekstrom, and H. Garoff. 2004. Isomerization of the intersubunit disulphide-bond in Env controls retrovirus fusion. EMBO J. 23:54-65.
20. Wallin, M., M. Ekström, and H. Garoff. 2006. Receptor-triggered but alkylation-arrested Env of murine leukemia virus reveals the transmembrane subunit in a prehairpin conformation. J. Virol. 80:9921-9925.
21. Wallin, M., R. Löving, M. Ekström, K. Li, and H. Garoff. 2005. Kinetic analyses of the surface-transmembrane disulfide bond isomerization-controlled fusion activation pathway in Moloney murine leukemia virus. J. Virol. 79:13856-13864.
22. Yang, C., and R. W. Compans. 1996. Analysis of the cell fusion activities of chimeric simian immunodeficiency virus-murine leukemia virus envelope proteins: inhibitory effects of the R peptide. J. Virol. 70:248-254.
23. Yang, C., and R. W. Compans. 1997. Analysis of the murine leukemia virus R peptide: delineation of the molecular determinants which are important for its fusion inhibition activity. J. Virol. 71:8490-8496.