Isomerization of the intersubunit disulphide-bond in Env controls retrovirus fusion

EMBO Journal

Volumn 23, Issue 1, 2004, Pages 54-65

  Wallin, Michael ^a   Ekström, Maria ^a   Garoff, Henrik ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Center for Biotechnology   (Sweden)

Author keywords

Disulphide bond isomerase motif; Fusion; Retrovirus

Indexed keywords

CALCIUM ION; DITHIOTHREITOL; ISOMERASE; PROTEIN SUBUNIT; THIOL; TRITON X 114; UREA; VIRUS ENVELOPE PROTEIN;

ALKYLATION; ANIMAL CELL; ARTICLE; CALCIUM DEPLETION; CONTROLLED STUDY; DISSOCIATION; DISULFIDE BOND; HEATING; ISOMERIZATION; MEMBRANE FUSION; MURINE LEUKEMIA VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; RECEPTOR BINDING; RETROVIRUS; SIGNAL TRANSDUCTION; VIRUS INFECTION;

3T3 CELLS; ANIMALS; ANTIBODIES, MONOCLONAL; CALCIUM; CELL LINE; CELL LINE, TUMOR; CHICKENS; CRICETINAE; CRICETULUS; DISULFIDES; GENE PRODUCTS, ENV; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; KINETICS; LEUKEMIA VIRUS, MURINE; MAGNESIUM; MEMBRANE FUSION; MICE; MODELS, BIOLOGICAL; MOLONEY MURINE LEUKEMIA VIRUS; RATS; RECEPTORS, VIRUS; RETROVIRIDAE; STEREOISOMERISM;

ANIMALIA; MURINAE; MURINE LEUKEMIA VIRUS; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0842307062     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600012     Document Type: Article

References (31)

1. Abrahamyan LG, Markosyan RM, Moore JP, Cohen FS, Melikyan GB (2003) Human immunodeficiency virus type 1 Env with an intersubunit disulfide bond engages coreceptors but requires bond reduction after engagement to induce fusion. J Virol 77: 5829-5836
2. Carr CM, Kim PS (1993) A spring-loaded mechanism for the conformational change of influenza hemagglutinin. Cell 73: 823-832
3. Chan DC, Fass D, Berger JM, Kim PS (1997) Core structure of gp41 from the HIV envelope glycoprotein. Cell 89: 263-273
4. Chesebro B, Britt W, Evans L, Wehrly K, Nishio J, Cloyd M (1983) Characterization of monoclonal antibodies reactive with murine leukemia viruses: use in analysis of strains of Friend MCF and Friend ecotropic murine leukemia virus. Virology 127: 134-148
5. Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM (1997) Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution. Science 277: 1662-1666
6. Fass D, Harrison SC, Kim PS (1996) Retrovirus envelope domain at 1.7 angstrom resolution. Nat Struct Biol 3: 465-469
7. Ferrari DM, Soling HD (1999) The protein disulphide-isomerase family: unravelling a string of folds. Biochem J 339: 1-10
8. Gallina A, Hanley TM, Mandel R, Trahey M, Broder CC, Viglianti GA, Ryser HJ (2002) Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. J Biol Chem 277: 50579-50588
9. Gatot JS, Callebaut I, Van Lint C, Demonte D, Kerkhofs P, Portetelle D, Burny A, Willems L, Kettmann R (2002) Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo. J Virol 76: 7956-7967
10. Gu J, Parthasarathi S, Varela-Echavarria A, Ron Y, Dougherty JP (1995) Mutations of conserved cysteine residues in the CWLC motif of the oncoretrovirus SU protein affect maturation and translocation. Virology 206: 885-893
11. Hernandez LD, Hoffman LR, Wolfsberg TG, White JM (1996) Virus-cell and cell-cell fusion. Annu Rev Cell Dev Biol 12: 627-661
12. Hunter E (1997), In Viral Entry and Receptors, Retroviruses, Coffin JM, Hughes SH, Varmus HE (eds) pp 71-119. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
13. Johnston ER, Radke K (2000) The SU and TM envelope protein subunits of bovine leukemia virus are linked by disulfide bonds, both in cells and in virions. J Virol 74: 2930-2935
14. Kobe B, Center RJ, Kemp BE, Poumbourios P (1999) Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proc Natl Acad Sci USA 96: 4319-4324
15. Lavillette D, Ruggieri A, Russell SJ, Cosset FL (2000) Activation of a cell entry pathway common to type C mammalian retroviruses by soluble envelope fragments. J Virol 74: 295-304
16. Leamnson RN, Halpern MS (1976) Subunit structure of the glycoprotein complex of avian tumor virus. J Virol 18: 956-968
17. Li KJ, Garoff H (1996) Production of infectious recombinant Moloney murine leukemia virus particles in BHK cells using Semliki Forest virus-derived RNA expression vectors. Proc Natl Acad Sci USA 93: 11658-11663
18. Liljestrom P, Garoff H (1991) A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Biotechnology (NY) 9: 1356-1361
19. Linder M, Linder D, Hahnen J, Schott HH, Stirm S (1992) Localization of the intrachain disulfide bonds of the envelope glycoprotein 71 from Friend murine leukemia virus. Eur J Biochem 203: 65-73
20. Maerz AL, Center RJ, Kemp BE, Kobe B, Poumbourios P (2000) Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure. J Virol 74: 6614-6621
21. Matthias LJ, Yam PT, Jiang XM, Vandegraaff N, Li P, Poumbourios P, Donoghue N, Hogg PJ (2002) Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1. Nat Immunol 3: 727-732
22. Mothes W, Boerger AL, Narayan S, Cunningham JM, Young JA (2000) Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein. Cell 103: 679-689
23. Opstelten DJ, Wallin M, Garoff H (1998) Moloney murine leukemia virus envelope protein subunits, gp70 and Pr15E, form a stable disulfide-linked complex. J Virol 72: 6537-6545
24. Pearson WR, Wood T, Zhang Z, Miller W (1997) Comparison of DNA sequences with protein sequences. Genomics 46: 24-36
25. Pinter A, Kopelman R, Li Z, Kayman SC, Sanders DA (1997) Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes. J Virol 71: 8073-8077
26. Pique C, Pham D, Tursz T, Dokhelar MC (1992) Human T-cell leukemia virus type 1 envelope protein maturation process: requirements for syncytium formation. J Virol 66: 906-913
27. Pizzato M, Marlow SA, Blair ED, Takeuchi Y (1999) Initial binding of murine leukemia virus particles to cells does not require specific Env-receptor interaction. J Virol 73: 8599-8611
28. Portis JL, McAtee FJ, Evans LH (1985) Infectious entry of murine retroviruses into mouse cells: evidence of a postadsorption step inhibited by acidic pH. J Virol 55: 806-812
29. Skehel JJ, Wiley DC (2000) Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem 69: 531-569
30. Suomalainen M, Garoff H (1994) Incorporation of homologous and heterologous proteins into the envelope of Moloney murine leukemia virus. J Virol 68: 4879-4889
31. Wang H, Kavanaugh MP, North RA, Kabat D (1991) Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter. Nature 352: 729-731