Specificity proteins Sp1 and Sp3 interact with the rat GTP Cyclohydrolase I proximal promoter to regulate transcription

Journal of Neurochemistry

Volumn 104, Issue 5, 2008, Pages 1233-1248

  Chandran, Nitya Sarath ^a   Vunnava, Prashanthi ^a   Wu, Yanning ^a   Kapatos, Gregory ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GTP Cyclohydrolase I; PC12 cell; Sp1; Sp3 transcription

Indexed keywords

BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP; ENHANCEOSOME; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HYBRID PROTEIN; NUCLEAR FACTOR Y; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP2; TRANSCRIPTION FACTOR SP3;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN; CELL STRAIN SL2; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DROSOPHILA; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METHYLATION; RAT; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; GTP CYCLOHYDROLASE; MUTAGENESIS, SITE-DIRECTED; PC12 CELLS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN TRANSPORT; RATS; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 39749157603     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05054.x     Document Type: Article

References (67)

1. Abou-Donia M. M., Wilson S. P., Zimmerman T. P., Nichol C. A. Viveros O. H. (1986) Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells. J. Neurochem. 46, 1190 1199.
2. Ahlgren R., Suske G., Waterman M. R. Lund J. (1999) Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene. J. Biol. Chem. 274, 19422 19428.
3. Anastasiadis P. Z., Bezin L., Gordon L. J., Imerman B., Blitz J., Kuhn D. M. Levine R. A. (1998) Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells. Neuroscience 86, 179 189.
4. Bauer M., Suppman S., Meyer M., Hesslinger C., Gasser T., Widner H. R. Ueffing M. (2002) Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurons. J. Neurochem. 82, 1300 1310.
5. WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18, 2872 2882.
6. Borestrom C., Zetterberg H., Liff K. Rymo L. (2003) Functional interaction of nuclear factor y and Sp1 is required for activation of the Epstein-Barr virus C promoter. J. Virol. 77, 821 829.
7. Bouwman P. Philipsen S. (2002) Regulation of the activity of Sp1-related transcription factors. Mol. Cell. Endocrinol. 195, 27 38.
8. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248 254.
9. Brandeis M., Frank D., Keshet I., Siegfried Z., Mendelsohn M., Nemes A., Temper V., Razin A. Cedar H. (1994) Sp1 elements protect a CpG island from de novo methylation. Nature 371, 435 438.
10. Chan Y., Fish J. E., D'Abreo C., Lin S., Robb G. B., Teichert A. M., Karantzoulis-Fegaras F., Keightley A., Steer B. M. Marsden P. A. (2004) The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation. J. Biol. Chem. 279, 35087 35100.
11. 1 binding is inhibited by (m)cp(m) CpG methylation. Gene 197, 67 71.
12. Courey A. J. Tjian R. (1988) Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell. 55, 887 898.
13. Courey A. J., Holtzman D. A., Jackson S. P. Tjian R. (1989) Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59, 827 836.
14. D'Sa C., Hirayama K., West A., Hahn M., Zhu M. Kapatos G. (1996) Tetrahydrobiopterin biosynthesis in C6 glioma cells: induction of GTP cyclohydrolase I gene expression by lipopolysaccharide and cytokine treatment. Brain Res. Mol. Brain Res. 41, 105 110.
15. Dignam J. D., Lebovitz R. M. Roeder R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475 1489.
16. Dooley K. A., Millinder S. Osbourne T. F. (1998) Sterol regulation of 3-hydroxy-3-methlglutaryl-coenzyme A synthase Gene through a direct interaction between sterol regulatory element binding protein and trimeric CCAAT-binding factor NF-Y. J. Biol. Chem. 273, 1349 1356.
17. Ge Y., Matherly L. H. Taub J. W. (2001) Transcriptional regulation of cell-specific expression of the human cystathionine β-synthase gene by differential binding of Sp1/Sp3 to the -1b promoter. J. Biol. Chem. 276, 43570 43579.
18. Gill G., Pascal E., Tseng Z. H. Tjian R. (1994) A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. Proc. Natl Acad. Sci. USA 91, 192 196.
19. Hagen G., Muller S., Beato M. Suske G. (1994) Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J. 13, 3843 3851.
20. Hagen G., Dennig J., Preiss A., Beato M. Suske G. (1995) Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J. Biol. Chem. 270, 24989 24994.
21. Harrington M. A., Jones P. A., Imagawa M. Karin M. (1988) Cytosine methylation does not affect binding of transcription factor Sp1. Proc. Natl. Acad. Sci. USA 85, 2066 2070.
22. Herman J. G. Baylin S. B. (2003) Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349, 2042 2054.
23. Hirayama K., Shimoji M., Swick L., Meyer A. Kapatos G. (2001) Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter. J. Neurochem. 79, 576 587.
24. Hoey T., Weinzlerl R. O. J., Gill G., Chen J. L., Dynlacht B. D. Tiyan R. (1993) Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell 72 (2 247 260.
25. Ishimaru N., Tabuchi A., Hara D., Hayashi H., Sugimoto T., Yasuhara M., Shiota J. Tsuda M. (2006) Regulation of neurotrophin-3 gene transcription by Sp3 and Sp4 in neurons. J. Neurochem. 97, 1 13.
26. Jackson S. P., MacDonald J. J., Lees-Miller S. Tjian R. (1990) GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63, 155 165.
27. Jaenisch R. Bird A. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl 245 254.
28. Kapatos G., Vunnava P. Wu Y. (2007) Protein Kinase A-dependent recruitment of RNA Polymerase II, NF-Y and C/EBPβ to the GTP cyclohydrolase I Proximal promoter without alterations in histone acetylation. J. Neurochem. 101, 1119 1133.
29. Kapatos G., Stegenga S. L. Hirayama K. (2000) Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene. J. Biol. Chem. 275, 5947 5957.
30. Kennett S. B., Udvadia A. J. Horowitz J. M. (1997) Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription. Nucleic Acids Res. 25, 3110 3117.
31. Klose R. Bird A. (2003) MeCP2 repression goes non-global. Science 302, 793 795
32. Krikun G., Schatz F., Mackman N., Guller S., Demopoulos R. Lockwood C. J. (2000) Regulation of tissue factor gene expression in human endometrium by transcription factors Sp1 and Sp3. Mol. Endocrinol. 14, 393 400.
33. Kwon N. S., Nathan C. F. Stuehr D. J. (1989) Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J. Biol. Chem. 264, 20496 20501.
34. Lee Y. H., Williams S. C., Baer M., Sterneck E., Gonzalez F. J. Johnson P. F. (1997) The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain. Mol. Cell. Biol. 17, 2038 2047.
35. Lentz S. I. Kapatos G. (1996) Tetrahydrobiopterin biosynthesis in the rat brain: heterogeneity of GTP cyclohydrolase I mRNA expression in monoamine-containing neurons. Neurochem. Int. 28, 569 582.
36. Lerner L. E., Gribanova Y. E., Whitaker L., Knox B. E. Farber D. B. (2002) The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX. J. Biol. Chem. 277, 25877 25883.
37. Li L. C. Dahiya R. (2002) Methprimer: designing primers for methylation PCRS. Bioinfomatics 18, 1427 1431.
38. Liu A., Prenger M. S., Norton D. D., Mei L., Kusiak J. W. Bai G. (2001) Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-d-aspartate receptor 1 promoter. J. Biol. Chem. 276, 45372 45379.
39. Macleod D., Charlton J., Mullins J. Bird A. P. (1994) Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8, 2282 2292.
40. Majello B., De Luca P., Hagen G., Suske G. Lania L. (1994) Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. Nucleic Acids Res. 22, 4914 4921.
41. Pang R. T., Lee L. T., Ng S. S., Yung W. H. Chow B. K. (2004) CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene. Mol. Endocrinol. 18, 471 483.
42. Papanikolaou N. A. Sabban E. L. (2000) Ability of Egr1 to activate tyrosine hydroxylase transcription in PC12 cells. J. Biol. Chem. 275, 26683 26689.
43. Persengiev S. P., Li J., Poulin M. L. Kilpatrick D. L. (2001) E2F2 converts reversibly differentiated PC12 cells to an irreversible, neurotrophin-dependent state. Oncogene 20, 5124 5131.
44. Pluss C., Werner E. R., Blau N., Wachter H. Pfeilschifter J. (1996) Interleukin 1β and cAMP trigger the expression of GTP cyclohydrolase I in rat mesangial cell. Biochem. J. 318, 665 671.
45. Poukka H., Aarnisalo P., Santti H., Janne O. A. Palvimo J. J. (2000) Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor mediated transcription by different mechanisms. J. Biol. Chem. 275, 571 579.
46. Roder K., Wolf S. S., Larkin K. J. Schweizer M. (1999) Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. Gene 234, 61 69.
47. Rohlff C., Ahmad S., Borellini F., Lei J. Glazer R. I. (1997) Modulation of transcription factor Sp1 by cAMP-dependent protein kinase. J. Biol. Chem. 272, 21137 21141.
48. Ryu S., Zhou S., Ladurner A. G. Tjian R. (1999) The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 397, 446 450.
49. Saluja D., Vassallo M. F. Tanese N. (1998) Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators. Mol. Cell. Biol. 18, 5734 5743.
50. Sapetschnig A., Koch F., Rischitor G., Mennenga T. Suske G. (2004) Complexity of translationally controlled transcription factor Sp3 isoform expression. J. Biol. Chem. 279, 42095 42105.
51. Sarraj J. A., Vinson C., Han J. Thiel G. (2005) Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors. J. Cell. Biochem. 96, 1003 1020.
52. Siegfried Z., Eden S., Mendelsohn M., Feng X., Tsuberi B. Z. Cedar H. (1999) DNA methylation represses transcription in vivo. Nat. Genet. 22, 203 206.
53. Smale S. T., Schmidt M. C., Berk A. J. Baltimore D. (1990) Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. Proc. Natl. Acad. Aci. 87, 4509 4513.
54. Sobue S., Hagiwara K., Banno Y., Tamiya-Koizumi K., Suzuki M., Kojima T., Asano H., Nozawa Y. Murate T. (2005) Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J. Neurochem. 95, 940 949.
55. Suske G. (1999) The Sp-family of transcription factors. Gene 238, 291 300.
56. Thony B., Auerbach G. Blau N. (2000) Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem. J. 347 Pt 1, 1 16.
57. Wang J. Bannon M. J. (2005) Sp1 and Sp3 activate transcription of the human dopamine transporter gene. J. Neurochem. 93, 474 482.
58. Wang W. Malcolm B. A. (1999) Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis. Biotechniques 26, 680 682.
59. Werner E. R., Werner-Felmayer G., Fuchs D., Hausen A., Reibnegger G., Yim J. J., Pfleiderer W. Wachter H. (1990) Tetrahydrobiopterin biosynthetic activities in human macrophages, fiBroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. J. Biol. Chem. 265, 3189 3192.
60. West A. B., Kapatos G., O'Farrell C., Gonzalez-de-Chavez F., Chiu K., Farrer M. J. Maidment N. T. (2004) N-myc regulates parkin expression. J. Biol. Chem. 279, 28896 28902.
61. Wu S. M., Kuo W. C., Hwu W. L., Hwa K. Y., Mantovani R. Lee Y. M. (2004) RNF4 is a coactivator for nuclear factor Y on GTP cyclohydrolase I proximal promoter. Mol. Pharmacol. 66, 1317 1324.
62. Xu Q., Ji Y. S. Schmedtje J. F. Jr. (2000) Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. J. Biol. Chem. 275, 24583 24589.
63. Yan G.-Z. Ziff E. B. (1997) Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. J. Neurosci. 17, 6122 6132.
64. Yu J. H., Schwartzbauer G., Kazlman A. Menon R. K. (1999) Role of the Sp family of transcription factors in the ontogeny of growth hormone receptor gene expression. J. Biol. Chem. 274, 34327 34336.
65. Yu B., Datta P. K. Bagchi S. (2003) Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res. 31, 5368 5376.
66. Zhu M., Hirayama K. Kapatos G. (1994) Regulation of tetrahydrobiopterin biosynthesis in cultured dopamine neurons by depolarization and cAMP. J. Biol. Chem. 269, 11825 11829.
67. Cip1 promoter. Mol. Cell. Biol. 23, 4056 4065.