Polycystic ovary syndrome

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volumn 22, Issue 2, 2008, Pages 261-274

  Homburg, Roy ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b BARZILAI MEDICAL CENTER   (Israel)

Author keywords

anovulation; aromatase inhibitors; clomiphene citrate; FSH; hirsutism; laparoscopic ovarian drilling; metformin; PCOS

Indexed keywords

ANASTROZOLE; ANDROGEN; ANTIANDROGEN; AROMATASE INHIBITOR; CLOMIFENE CITRATE; DIANE; DROSPIRENONE PLUS ETHINYLESTRADIOL; FINASTERIDE; FLUTAMIDE; FOLLITROPIN; GLITAZONE DERIVATIVE; GONADORELIN AGONIST; GONADOTROPIN; LETROZOLE; LUTEINIZING HORMONE; METFORMIN; ORAL CONTRACEPTIVE AGENT; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SPIRONOLACTONE; TAMOXIFEN;

ABDOMINAL DISTENSION; ACNE; ANDROGEN SYNTHESIS; ANOVULATION; BREAST TENDERNESS; CLINICAL FEATURE; CLINICAL TRIAL; CONGENITAL MALFORMATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE INFERTILITY; FERTILIZATION IN VITRO; GASTROINTESTINAL SYMPTOM; HIRSUTISM; HOT FLUSH; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; HYPERMENORRHEA; INSULIN RESISTANCE; LAPAROSCOPIC SURGERY; LIFESTYLE MODIFICATION; LIVER TOXICITY; LOW DRUG DOSE; MALE TYPE ALOPECIA; MENSTRUATION DISORDER; MONOTHERAPY; MULTIPLE PREGNANCY; NONHUMAN; OBESITY; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PATHOPHYSIOLOGY; PREGNANCY RATE; PREVALENCE; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SPONTANEOUS ABORTION; TERATOGENICITY; VISUAL DISORDER; WEIGHT REDUCTION;

ACNE VULGARIS; ANDROGEN ANTAGONISTS; AROMATASE INHIBITORS; CLOMIPHENE; FEMALE; FERTILITY AGENTS, FEMALE; GONADOTROPINS, PITUITARY; HIRSUTISM; HUMANS; INFERTILITY, FEMALE; INSULIN RESISTANCE; METFORMIN; POLYCYSTIC OVARY SYNDROME; WEIGHT LOSS;

EID: 39749094424     PISSN: 15216934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2007.07.009     Document Type: Review

References (29)

1. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
2. Adams J., Polson D.W., and Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. BMJ 293 (1986) 355-359
3. Homburg R. Polycystic ovary syndrome - from gynaecological curiosity to multisystem endocrinopathy. Hum Reprod 11 (1996) 29-39
4. Amato P., and Simpson J.L. The genetics of polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol 18 (2004) 707-718
5. Abbott D.H., Barnett D.K., Bruns C.M., et al. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?. Hum Reprod Update 11 (2005) 357-374
6. Balen A.H., Conway G.S., Kaltsas G., et al. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod 10 (1995) 2705-2712
7. Webber L.J., Stubbs S., Stark J., et al. Formation and early development of follicles in the polycystic ovary. Lancet 362 (2003) 1017-1021
8. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanisms and implication for pathogenesis. Endocr Rev 18 (1997) 774-800
9. Kiddy D.S., Hamilton-Fairley D., Bush A., et al. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin Endocrinol 36 (1992) 105-111
10. Pasquali R., Antenucci D., Casmirri F., et al. Clinical and hormonal characteristics of obese amenorrheic hyperandrogenic women before and after weight loss. J Clin Endocrinol Metab 68 (1989) 173-179
11. Rostami-Hodjegan A., Lennard M.S., Tucker G.T., et al. Monitoring plasma concentrations to individualize treatment with clomiphene citrate. Fertil Steril 81 (2004) 1187-1193
12. Homburg R. Clomiphene citrate - end of an era?. Hum Reprod 20 (2005) 2043-2051
13. Mitwally M.F., and Casper R.F. Use of aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril 75 (2001) 305-309
14. Tulandi T., Martin J., Al-Fadhli R., et al. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril 85 (2006) 1761-1765
15. Fleming R., Hopkinson Z.E., Wallace A.M., et al. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 87 (2002) 569-574
16. Palomba S., Russo T., Orio F., et al. Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome. Hum Reprod 21 (2006) 457-465
17. Tang T., Glanville J., Hayden C.J., et al. Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study. Hum Reprod 21 (2006) 80-89
18. Lord J.M., Flight I.H., and Norman R.J. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev (2003) CD003053
19. Moll E., Bossuyt P.M.M., Korevaar J.C., et al. Ovulation induction in women with newly diagnosed polycystic ovary syndrome. A randomized double-blind clinical trial comparing clomiphene citrate plus metformin with clomiphene citrate and placebo. BMJ 332 (2006) 1485
20. George S.S., George K., Irwin C., et al. Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial. Hum Reprod 18 (2003) 299-304
21. Kjotrod S., von During V., and Carlsen S.M. Metformin treatment before IVF/ICSI in PCOS women: a prospective, randomized, double-blind study. Hum Reprod 19 (2004) 1315-1322
22. Tang T., Glanville J., Orsi N., et al. The use of metformin for women with PCOS undergoing IVF treatment. Hum Reprod 21 (2006) 1416-1425
23. Glueck C.J., Goldenberg N., Pranikoff J., et al. Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy. Hum Reprod 19 (2004) 1323-1330
24. Homburg R., and Howles C.M. Low dose FSH therapy for anovulatory infertility associated with polycystic ovary syndrome: rationale, reflections and refinements. Hum Reprod Update 5 (1999) 493-499
25. Van Santbrink E.J.P., and Fauser B.C.J.M. Urinary follicle-stimulating hormone for normogonadotropic clomiphene resistant anovulatory infertility: prospective, randomized comparison between low dose step-up and step-down dose regimens. J Clin Endocrinol Metab 82 (1997) 3597-3602
26. Christin-Maitre S., and Hugues J.N. A comparative randomized multricentric study comparing the step-up versus the step-down protocol in polycystic ovary syndrome. Hum Reprod 18 (2003) 1621-1631
27. Donesky B.W., and Adashi E.Y. Surgical ovulation induction: the role of ovarian diathermy in polycystic ovary syndrome. Bailliere's Clin Endocrinol Metab 10 (1996) 293-310
28. Li T.C., Saravelos H., Chow M.S., et al. Factors affecting the outcome of laparoscopic ovarian drilling for polycystic ovarian syndrome in women with anovulatory infertility. Br J Obstet Gynaecol 105 (1998) 338-344
29. Legro R.S., Barnhart H.X., Schlaff W.D., et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 356 (2007) 551-556