-
1
-
-
0029873153
-
Can metformin reduce insulin resistance in polycystic ovary syndrome?
-
Acbay, O. and Gundogdu, S. (1996) Can metformin reduce insulin resistance in polycystic ovary syndrome? Fertil. Steril., 65, 946-949.
-
(1996)
Fertil. Steril.
, vol.65
, pp. 946-949
-
-
Acbay, O.1
Gundogdu, S.2
-
2
-
-
0022519137
-
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsuitism
-
Adams, J., Polson, D.W. and Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsuitism. Br. Med. J., 293, 355-359.
-
(1986)
Br. Med. J.
, vol.293
, pp. 355-359
-
-
Adams, J.1
Polson, D.W.2
Franks, S.3
-
3
-
-
0025759369
-
Polycystic ovarian disease
-
Barbieri, R.L. (1991) Polycystic ovarian disease. Annu. Rev. Med., 42, 199-204.
-
(1991)
Annu. Rev. Med.
, vol.42
, pp. 199-204
-
-
Barbieri, R.L.1
-
4
-
-
0022647650
-
Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism
-
Barbieri, R.L., Makris, A., Randall, R.W., Daniels, G., Kistner, R.W. and Ryan, K.J. (1986) Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J. Clin. Endocrinol. Metab., 62, 904-910.
-
(1986)
J. Clin. Endocrinol. Metab.
, vol.62
, pp. 904-910
-
-
Barbieri, R.L.1
Makris, A.2
Randall, R.W.3
Daniels, G.4
Kistner, R.W.5
Ryan, K.J.6
-
5
-
-
0023713274
-
The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism
-
Barbieri, R.L., Smith, S. and Ryan, K.J. (1988) The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. Fertil. Steril., 50, 197-211.
-
(1988)
Fertil. Steril.
, vol.50
, pp. 197-211
-
-
Barbieri, R.L.1
Smith, S.2
Ryan, K.J.3
-
6
-
-
0020308864
-
"Proving the Null Hypothesis" in clinical trials
-
Blackwelder, W.C. (1982) "Proving the Null Hypothesis" in clinical trials. Controll. Clin. Trials, 3, 345-353.
-
(1982)
Controll. Clin. Trials
, vol.3
, pp. 345-353
-
-
Blackwelder, W.C.1
-
7
-
-
0024600102
-
Estimates of In vivo insulin action in man: Comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies
-
Bonora, E., Moghetti, P., Zancanaro, C., Cigolini, M., Querena, M., Cacciatori, V., Corgnati, A. and Muggeo, M. (1989) Estimates of In vivo insulin action in man: Comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J. Clin. Endocrinol. Metab., 68, 374-378.
-
(1989)
J. Clin. Endocrinol. Metab.
, vol.68
, pp. 374-378
-
-
Bonora, E.1
Moghetti, P.2
Zancanaro, C.3
Cigolini, M.4
Querena, M.5
Cacciatori, V.6
Corgnati, A.7
Muggeo, M.8
-
8
-
-
0020635004
-
Insulin resistance in nonobese patients with polycystic ovarian disease
-
Chang, R.J., Nakamura, R.M., Judd, H.L. and Kaplan, S.A. (1983) Insulin resistance in nonobese patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 57, 356-359.
-
(1983)
J. Clin. Endocrinol. Metab.
, vol.57
, pp. 356-359
-
-
Chang, R.J.1
Nakamura, R.M.2
Judd, H.L.3
Kaplan, S.A.4
-
9
-
-
0026756778
-
Cellular mechanisms of insulin resistance in polycystic ovarian syndrome
-
Ciaraldi, T.P., El-Roeiy, A., Madar, Z., Reichart, D., Olefsky, J.M. and Yen, S.C. (1992) Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. J. Clin. Endocrinol. Metab., 75, 577-583.
-
(1992)
J. Clin. Endocrinol. Metab.
, vol.75
, pp. 577-583
-
-
Ciaraldi, T.P.1
El-Roeiy, A.2
Madar, Z.3
Reichart, D.4
Olefsky, J.M.5
Yen, S.C.6
-
10
-
-
0028843928
-
Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women
-
Clark, A.M., Ledger, W., Galletly, C., Tomlinson, L., Blaney F., Wang, X. and Norman, R.J. (1995) Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum. Reprod., 10, 2705-2712.
-
(1995)
Hum. Reprod.
, vol.10
, pp. 2705-2712
-
-
Clark, A.M.1
Ledger, W.2
Galletly, C.3
Tomlinson, L.4
Blaney, F.5
Wang, X.6
Norman, R.J.7
-
11
-
-
0018777709
-
Metformin in management of pregnant insulin independent diabetics
-
Coetzee, E.J. and Jackson, W.P. (1979) Metformin in management of pregnant insulin independent diabetics. Diabetologia, 16, 241-245.
-
(1979)
Diabetologia
, vol.16
, pp. 241-245
-
-
Coetzee, E.J.1
Jackson, W.P.2
-
12
-
-
0021265719
-
Oral hypoglycaemics in the first trimester and fetal outcome
-
Coetzee, E.J. and Jackson, W.P. (1984) Oral hypoglycaemics in the first trimester and fetal outcome. S. Afr. Med. J., 65, 635-637.
-
(1984)
S. Afr. Med. J.
, vol.65
, pp. 635-637
-
-
Coetzee, E.J.1
Jackson, W.P.2
-
13
-
-
0033179753
-
Effects of metformin on gonadotropin induced ovulation in women with polycystic ovary syndrome
-
De Leo, V., Marca, A., Ditto, A., Morgante, G. and Cianci, A. (1999) Effects of metformin on gonadotropin induced ovulation in women with polycystic ovary syndrome. Fertil. Steril., 72, 282-285.
-
(1999)
Fertil. Steril.
, vol.72
, pp. 282-285
-
-
De Leo, V.1
Marca, A.2
Ditto, A.3
Morgante, G.4
Cianci, A.5
-
14
-
-
0028299983
-
Effects of biguanide class of oral hypoglycemic agents on mouse embryogenesis
-
Denno, K.M. and Sadler, T.W. (1994) Effects of biguanide class of oral hypoglycemic agents on mouse embryogenesis. Teratology, 49, 260-266.
-
(1994)
Teratology
, vol.49
, pp. 260-266
-
-
Denno, K.M.1
Sadler, T.W.2
-
15
-
-
0024437305
-
Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
-
Dunaif, A., Segal, K.R., Futterweit, W. and Dobrjansky, A. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165-1174.
-
(1989)
Diabetes
, vol.38
, pp. 1165-1174
-
-
Dunaif, A.1
Segal, K.R.2
Futterweit, W.3
Dobrjansky, A.4
-
16
-
-
0031015005
-
Effects of metformin on insulin secretion, insulin action and ovarian steroidogenesis in women with polycystic ovary syndrome
-
Ehrmann, D.A., Cavaghan, M.K., Imperial, J., Sturis, J., Rosenfield, R.L. and Polonsky, K.S. (1997) Effects of metformin on insulin secretion, insulin action and ovarian steroidogenesis in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 82, 524-530.
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 524-530
-
-
Ehrmann, D.A.1
Cavaghan, M.K.2
Imperial, J.3
Sturis, J.4
Rosenfield, R.L.5
Polonsky, K.S.6
-
17
-
-
0029095150
-
Polycystic ovary syndrome
-
Franks, S. (1995) Polycystic ovary syndrome. N. Engl. J. Med., 333, 853-861.
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 853-861
-
-
Franks, S.1
-
18
-
-
0036153384
-
Metformin therapy improves ovulatory rates, cervical scores and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome
-
Kocak, M., Caliskan, E., Simsir, C. and Haberal, A. (2002) Metformin therapy improves ovulatory rates, cervical scores and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome. Fertil. Steril., 77, 101-106.
-
(2002)
Fertil. Steril.
, vol.77
, pp. 101-106
-
-
Kocak, M.1
Caliskan, E.2
Simsir, C.3
Haberal, A.4
-
19
-
-
0034111902
-
Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome
-
Kolodziejczyk, B., Duleba, A.J., Spaczynski, R.Z. and Pawelczyk, L. (2000) Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil. Steril., 73, 1149-1154.
-
(2000)
Fertil. Steril.
, vol.73
, pp. 1149-1154
-
-
Kolodziejczyk, B.1
Duleba, A.J.2
Spaczynski, R.Z.3
Pawelczyk, L.4
-
20
-
-
0031787388
-
A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome
-
Legro, R.S., Finegood, D. and Dunaif, A. (1998) A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 83, 2694-2698.
-
(1998)
J. Clin. Endocrinol. Metab.
, vol.83
, pp. 2694-2698
-
-
Legro, R.S.1
Finegood, D.2
Dunaif, A.3
-
21
-
-
0032708106
-
High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome
-
Mitwally, M.F., Kuscu, N.K. and Yalcinkaya, T.M. (1999) High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome. Hum. Reprod., 14, 2700-2703.
-
(1999)
Hum. Reprod.
, vol.14
, pp. 2700-2703
-
-
Mitwally, M.F.1
Kuscu, N.K.2
Yalcinkaya, T.M.3
-
22
-
-
0034458234
-
Metformin effects on clinical features, endocrine and metabolic profiles and insulin sensitivity in polycystic ovary syndrome: A randomized double-blind, placebo controlled 6-month trial, followed by open long term clinical evaluation
-
Moghetti, P., Castello, R., Negri, C., Tosi, F., Perrone, F., Caputo, M., Zanolin, E. and Muggeo, M. (2000) Metformin effects on clinical features, endocrine and metabolic profiles and insulin sensitivity in polycystic ovary syndrome: A randomized double-blind, placebo controlled 6-month trial, followed by open long term clinical evaluation. J. Clin. Endocrinol. Metab., 85, 139-146.
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 139-146
-
-
Moghetti, P.1
Castello, R.2
Negri, C.3
Tosi, F.4
Perrone, F.5
Caputo, M.6
Zanolin, E.7
Muggeo, M.8
-
23
-
-
0031968394
-
Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome
-
Morin-Papunen, L.C., Koivunen, R.M., Ruokonen, A. and Martikainen, H.K. (1998) Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. Fertil. Steril., 69, 691-696.
-
(1998)
Fertil. Steril.
, vol.69
, pp. 691-696
-
-
Morin-Papunen, L.C.1
Koivunen, R.M.2
Ruokonen, A.3
Martikainen, H.K.4
-
24
-
-
0032958412
-
Polycystic ovary syndrome. Insulin resistance and ovulatory responses to clomiphene citrate
-
Murakawa, H., Hasegawa, I., Kurabayashi, T. and Tanaka, K. (1999) Polycystic ovary syndrome. Insulin resistance and ovulatory responses to clomiphene citrate. J. Reprod. Med., 44, 23-27.
-
(1999)
J. Reprod. Med.
, vol.44
, pp. 23-27
-
-
Murakawa, H.1
Hasegawa, I.2
Kurabayashi, T.3
Tanaka, K.4
-
25
-
-
0029796476
-
Decreases in ovarian cytochrome p450c17α activity and serum free testosterone after reduction in insulin secretion in polycystic ovary syndrome
-
Nestler, J.E. and Jakubowicz, D.J. (1996) Decreases in ovarian cytochrome p450c17α activity and serum free testosterone after reduction in insulin secretion in polycystic ovary syndrome. N. Engl. J. Med., 335, 617-623.
-
(1996)
N. Engl. J. Med.
, vol.335
, pp. 617-623
-
-
Nestler, J.E.1
Jakubowicz, D.J.2
-
26
-
-
0030783316
-
Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian p450c17α activity and serum androgens
-
Nestler, J.E. and Jakubowicz, D.J. (1997) Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian p450c17α activity and serum androgens. J. Clin. Endocrinol. Metab., 82, 4075-4079.
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 4075-4079
-
-
Nestler, J.E.1
Jakubowicz, D.J.2
-
27
-
-
0024355532
-
The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome
-
Nestler, J.E., Clore, J.N. and Blackard, W.G. (1989) The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome. Am. J. Obstet. Gynecol., 161, 1095-1097.
-
(1989)
Am. J. Obstet. Gynecol.
, vol.161
, pp. 1095-1097
-
-
Nestler, J.E.1
Clore, J.N.2
Blackard, W.G.3
-
28
-
-
0026028184
-
A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome
-
Nestler, J.E., Powers, L.P., Matt, D.W., Steingold, K.A., Plymate, S.R., Rittmaster, R.S., Clore, J.N. and Blackard, W.G. (1991) A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 72, 83-89.
-
(1991)
J. Clin. Endocrinol. Metab.
, vol.72
, pp. 83-89
-
-
Nestler, J.E.1
Powers, L.P.2
Matt, D.W.3
Steingold, K.A.4
Plymate, S.R.5
Rittmaster, R.S.6
Clore, J.N.7
Blackard, W.G.8
-
29
-
-
0032565971
-
Effects of metformin on spontaneous and clomiphene induced ovulation in the polycystic ovary syndrome
-
Nestler, J.E., Jakubowicz, D.J., Evans, W.S. and Pasquali, R. (1998) Effects of metformin on spontaneous and clomiphene induced ovulation in the polycystic ovary syndrome. N. Engl. J. Med., 338, 1876-1880.
-
(1998)
N. Engl. J. Med.
, vol.338
, pp. 1876-1880
-
-
Nestler, J.E.1
Jakubowicz, D.J.2
Evans, W.S.3
Pasquali, R.4
-
30
-
-
0034886493
-
Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: A randomized, double blinded placebo-controlled trial
-
Ng, E.H., Wat, N.M. and Ho, P.C. (2001) Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: A randomized, double blinded placebo-controlled trial. Hum. Reprod., 16, 1625-1631.
-
(2001)
Hum. Reprod.
, vol.16
, pp. 1625-1631
-
-
Ng, E.H.1
Wat, N.M.2
Ho, P.C.3
-
31
-
-
0029061489
-
Effects of insulin like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line
-
Olson, B.R., Scott, D.C., Wetsel, W.C., Elliot, S.J., Tomic, M., Stojilkovic, S., Nieman, L.K. and Wray, S. (1995) Effects of insulin like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line. Neuroendocrinology, 62, 155-165.
-
(1995)
Neuroendocrinology
, vol.62
, pp. 155-165
-
-
Olson, B.R.1
Scott, D.C.2
Wetsel, W.C.3
Elliot, S.J.4
Tomic, M.5
Stojilkovic, S.6
Nieman, L.K.7
Wray, S.8
-
32
-
-
0035708055
-
Insulin resistance in clomiphene responders and nonresponders with polycystic ovarian disease and therapeutic effects of metformin
-
Parsanezhad, M.E., Alborzi, S., Zarei, A., Dehbashi, S. and Omrani, G. (2001) Insulin resistance in clomiphene responders and nonresponders with polycystic ovarian disease and therapeutic effects of metformin. Int. J. Gynaecol. Obstet., 75, 43-50.
-
(2001)
Int. J. Gynaecol. Obstet.
, vol.75
, pp. 43-50
-
-
Parsanezhad, M.E.1
Alborzi, S.2
Zarei, A.3
Dehbashi, S.4
Omrani, G.5
-
33
-
-
0024503528
-
Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: The difference between responders and nonresponders
-
Polson, D.W., Kiddy, D.S., Mason, H.D. and Franks, S. (1989) Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: The difference between responders and nonresponders. Fertil. Steril., 51, 30-34.
-
(1989)
Fertil. Steril.
, vol.51
, pp. 30-34
-
-
Polson, D.W.1
Kiddy, D.S.2
Mason, H.D.3
Franks, S.4
-
34
-
-
0028326775
-
Insulin sensitivity in women with polycystic ovary syndrome: Relationship to hyperandrogenemia
-
Rajkhowa, M., Bicknell, J., Jones, M. and Clayton, R.N. (1994) Insulin sensitivity in women with polycystic ovary syndrome: Relationship to hyperandrogenemia. Fertil. Steril., 61, 605-612.
-
(1994)
Fertil. Steril.
, vol.61
, pp. 605-612
-
-
Rajkhowa, M.1
Bicknell, J.2
Jones, M.3
Clayton, R.N.4
-
35
-
-
0027251744
-
The role of adrenal hyperandrogenism, insulin resistance and obesity in the pathogenesis of polycystic ovarian syndrome
-
Rittmaster, R.S., Deshwal, N. and Lehman, L. (1993) The role of adrenal hyperandrogenism, insulin resistance and obesity in the pathogenesis of polycystic ovarian syndrome. J. Clin. Endocrinol. Metab., 76, 1295-1300.
-
(1993)
J. Clin. Endocrinol. Metab.
, vol.76
, pp. 1295-1300
-
-
Rittmaster, R.S.1
Deshwal, N.2
Lehman, L.3
-
36
-
-
0032806555
-
The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome
-
Unluhizarci, K., Kelestimur, F., Bayram, F., Sahin, Y. and Tutus, A. (1999) The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome. Clin. Endocrinol., 51, 231-236.
-
(1999)
Clin. Endocrinol.
, vol.51
, pp. 231-236
-
-
Unluhizarci, K.1
Kelestimur, F.2
Bayram, F.3
Sahin, Y.4
Tutus, A.5
-
37
-
-
0035145624
-
Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone
-
Vandermolen, D.T., Ratts, V.S., Evans, W.S., Stovall, D.W., Kauma, S.W. and Nestler, J.E. (2001) Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil. Steril., 75, 310-315.
-
(2001)
Fertil. Steril.
, vol.75
, pp. 310-315
-
-
Vandermolen, D.T.1
Ratts, V.S.2
Evans, W.S.3
Stovall, D.W.4
Kauma, S.W.5
Nestler, J.E.6
-
38
-
-
0028315971
-
Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy
-
Velazquez, E.M., Mendoza, S., Hamer, T., Sosa, F. and Glueck, C.J. (1994) Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism, 43, 647-654.
-
(1994)
Metabolism
, vol.43
, pp. 647-654
-
-
Velazquez, E.M.1
Mendoza, S.2
Hamer, T.3
Sosa, F.4
Glueck, C.J.5
|