Scientific monogamy: Thirty years dancing with the same bug - 2007 Thomas Parran award lecture

Sexually Transmitted Diseases

Volumn 35, Issue 1, 2008, Pages 2-7

  Lukehart, Sheila A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; VIRULENCE FACTOR;

ANTIBODY TITER; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; BACILLUS SUBTILIS; BACTERIUM CULTURE; BACTERIUM ISOLATE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONFERENCE PAPER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; NEUTROPHIL; NONHUMAN; OPEN READING FRAME; PHAGOCYTOSIS; SEXUALLY TRANSMITTED DISEASE; SYPHILIS; TH1 CELL; TREPONEMA PALLIDUM; UNITED STATES; ARTICLE; MICROBIOLOGY;

HUMANS; SYPHILIS; TREPONEMA PALLIDUM;

EID: 39649102172     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/OLQ.0b013e318162c4f2     Document Type: Conference Paper

References (37)

1. Parran T. Shadow on the Land. New York: Reynal & Hitchcock, 1937.
2. Miller JN. Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by g- irradiation. J Immunol 1973; 110:1206-1215.
3. Radolf JD, Lukehart SA, eds. Pathogenic Treponema: Molecular and Cellular Biology. Norfolk, England: Caister Academic Press, 2006.
4. Lukehart SA, Miller JN. Demonstration of the in vitro phagocytosis of Treponema pallidum by rabbit peritoneal macrophages. J Immunol 1978; 121:2014-2024.
5. Lukehart SA, Baker-Zander SA, Lloyd RM, et al. Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions J Immunol 1980; 124:461-467.
6. Lukehart SA, Baker-Zander SA, Sell S. Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens J Immunol 1980; 124:454-460.
7. Marra CM, Maxwell CL, Smith SL, et al. Cerebrospinal fluid abnormalities in patients with syphilis: Association with clinical and laboratory features. J Infect Dis 2004; 189:369-376.
8. Marra CM. Deja vu all over again: When to perform a lumbar puncture in HIV-infected patients with syphilis. Sex Transm Dis 2007; 34:145-146.
9. Marra CM, Maxwell CL, Tantalo L, et al. Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: Does HIV status matter? Clin Infect Dis 2004; 38:1001-1006.
10. Shaffer JM, Baker-Zander SA, Lukehart SA. Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes. Infect Immun 1993; 61:781-784.
11. Lukehart SA. Activation of macrophages by products of lymphocytes from normal and syphilitic rabbits. Infect Immun 1982; 37:64-69.
12. Van Voorhis WC, Barrett LK, Koelle DM, et al. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis 1996; 173:491-495.
13. Van Voorhis WC, Barrett LK, Nasio JM, et al. Lesions of primary and secondary syphilis contain activated cytolytic T cells. Infect Immun 1996; 64:1048-1050.
14. Godornes C, Leader BT, Molini BJ, et al. Quantitation of rabbit cytokine mRNA by real-time RT-PCR. Cytokine 2007; 38:1-7.
15. + Lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis. Infect Immun 2007; 75:3021-3026.
16. Fitzgerald TJ. The Th1/Th2-like switch in syphilitic infection: Is it detrimental? Infect Immun 1992; 60:3475-3479.
17. Lukehart SA, Shaffer JM, Baker-Zander SA. A subpopulation of Treponema pallidum is resistant to phagocytosis: Possible mechanism of persistence. J Infect Dis 1992; 166:1449-1453.
18. Radolf JD, Norgard MV, Schulz WW. Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum. Proc Natl Acad Sci USA 1989; 86:2051-2055.
19. Walker EM, Zampighi GA, Blanco DR, et al. Demonstration of rare protein in the outer membrane of Treponema pallidum subsp. pallidum by freeze-fracture analysis. J Bacteriol 1989; 171:5005-5011.
20. Bishop NH, Miller JN. Humoral immunity in experimental syphilis. II. The relationship of neutralizing factors in immune serum to acquired resistance. J Immunol 1976; 117:197-207.
21. Nelson RA, Mayer MM. Immobilization of Treponema pallidum in vitro by antibody produced in syphilis infection. J Exp Med 1949; 89:396-393.
22. Alder JD, Friess L, Tengowski M, et al. Phagocytosis of opsonized Treponema pallidum subsp. pallidum proceeds slowly. Infect Immun 1990; 58:1167-1173.
23. Fraser CM, Norris SJ, Weinstock GM, et al. Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 1998; 281:375-388.
24. Centurion-Lara A, Castro C, Barrett L, et al. Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response. J Exp Med 1999; 189:647-656.
25. Centurion-Lara A, Sun ES, Barrett LK, et al. Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates. J Bacteriol 2000; 182:2332-2335.
26. Sun ES, Molini BJ, Barrett LK, et al. Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity. Microbes Infect 2004; 6:725-737.
27. Giacani L, Molini B, Godornes C, et al. Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis. Infect Immun 2007; 75:104 -112.
28. Leader BT, Hevner K, Molini BJ, et al. Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum Infect Immun 2003; 71:6054-6057.
29. Giacani L, Lukehart S, Centurion-Lara A. Length of guanosine homopolymeric repeats modulates promoter activity of Subfamily II tpr genes of Treponema pallidum ssp. Pallidum. FEMS Immunol Med Microbiol 2007; 51:289-301.
30. Morgan CA, Lukehart SA, Van Voorhis WC. Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model. Infect Immun 2002; 70:6811-6816.
31. Hazlett KRO, Sellati TJ, Nguyen TT, et al. The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity. J Exp Med 2001; 193:1015-1026.
32. Centurion-Lara A, Godornes C, Castro C, et al. The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles. Infect Immun 2000; 68:824-831.
33. LaFond RE, Centurion-Lara A, Godornes C, et al. Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates J Bacteriol 2003; 185:6262-6268.
34. Centurion-Lara A, LaFond RE, Hevner K, et al. Gene conversion: A mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol 2004; 52:1579-1596.
35. Morgan CA, Molini BJ, Lukehart SA, et al. Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection. J Immunol 2002; 169:952-957.
36. Morgan CA, Lukehart SA, Van Voorhis WC. Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K. Infect Immun 2003; 71:5605-5612.
37. LaFond RE, Molini BJ, Van Voorhis WC, et al. Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis. Infect Immun 2006; 74:6244-6251.