Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model

Infection and Immunity

Volumn 70, Issue 12, 2002, Pages 6811-6816

  Morgan, Cecilia A ^a   Lukehart, Sheila A ^a   Van Voorhis, Wesley C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; PROTEIN TPRK; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SPLEEN CELL; SYPHILIS; T LYMPHOCYTE; TREPONEMA PALLIDUM;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; DISEASE MODELS, ANIMAL; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MALE; RABBITS; SYPHILIS, CUTANEOUS; T-LYMPHOCYTES; TREPONEMA PALLIDUM;

EID: 0036892167     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.12.6811-6816.2002     Document Type: Article

References (46)

1. Adler, M. W. 1996. Sexually transmitted diseases: Control in developing countries. Genitourin. Med. 72:83-88.
2. Agacfidan, A., and P. Kohl. 1999. Sexually transmitted diseases (STDs) in the world. FEMS Immunol. Med. Microbiol. 24:431-435.
3. Arroll, T. W., A. Centurion-Lara, S. A. Lukehart, and W. C. Van Voorhis. 1999. T-cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection. Infect. Immun. 67:4757-4763.
4. Baker-Zander, S. A., and S. A. Lukehart. 1992. Macrophage-mediated killing of opsonized Treponema pallidum. J. Infect. Dis. 165:69-74.
5. Baker-Zander, S., and S. Sell. 1980. A histopathologic and immunologic study of the course of syphilis in the experimentally infected rabbit. Demonstration of long-lasting cellular immunity. Am. J. Pathol. 101:387-413.
6. Battu, V. R., P. J. Homer, P. K. Taylor, A. E. Jephcott, and S. I. Egglestone. 1997. Locally acquired heterosexual outbreak of syphilis in Bristol. Lancet 350:1100-1101.
7. Bishop, N. H., and J. N. Miller. 1976. Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization. J. Immunol. 117:191-207.
8. Borenstein, L. A., J. D. Radolf, T. E. Fehniger, D. R. Blanco, J. N. Miller, and M. A. Lovett. 1988. Immunization of rabbits with recombinant Treponema pallidum surface antigen 4D alters the course of experimental syphilis. J. Immunol. 140:2415-2421.
9. Borisenko, K. K., L. I. Tichonova, and A. M. Renton. 1999. Syphilis and other sexually transmitted infections in the Russian Federation. Int. J. Sex. Transm. Dis. AIDS 10:665-668.
10. Cameron, C. E., C. Castro, S. A. Lukehart, and W. C. Van Voorhis. 1998. Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase. Infect. Immun. 66:5763-5770.
11. Cameron, C. E., S. A. Lukehart, C. Castro, B. Molini, C. Godornes, and W. C. Van Voorhis. 2000. Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92. J. Infect. Dis. 181:1401-1413.
12. Centers for Disease Control and Prevention. 1998. Congenital syphilis-United States. Morb. Mortal. Wkly. Rep. 48:757-761.
13. Centers for Disease Control and Prevention. 1999. Primary and secondary syphilis-United States. Morb. Mortal. Wkly. Rep. 48:873-878.
14. Centurion-Lara, A., C. Castro, L. Barrett, C. Cameron, M. Mostowfi, W. C. Van Voorhis, and S. A. Lukehart. 1999. Treponema pallidum major sheath protein homologue TprK is a target of opsonic antibody and the protective immune response. J. Exp. Med. 189:647-656.
15. Centurion-Lara, A., C. Godornes, C. Castro, W. C. Van Voorhis, and S. A. Lukehart. 2000. The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles. Infect. Immun. 68:824-831.
16. Champion, C. I., J. N. Miller, L. A. Borenstein, M. A. Lovett, and D. R. Blanco. 1990. Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis. Infect. Immun. 58:3158-3161.
17. Engelkens, H. J. H., F. J. W. ten Kate, J. Judanarso, V. D. Vuzevski, J. B. H. J. van Lier, J. C. J. Godschalk, J. J. van der Sluis, and E. Stolz. 1993. The localization of treponemes and characterization of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. Genitourin. Med. 69:102-107.
18. Gerbase, A. C., J. T. Rowley, D. H. Heymann, S. F. Berkley, and P. Piot. 1998. Global prevalence and incidence estimates of selected curable STDs. Sex. Transm. Infect. 74(Suppl. 1):S12-S16.
19. Gregory, N., M. Sanchez, and M. R. Buchness. 1990. The spectrum of syphilis in patients with human immunodeficiency virus infection. J. Am. Acad. Dermatol. 22:1061-1067.
20. Hazlett, K. R., T. J. Sellati, T. T. Nguyen, D. L. Cox, M. L. Clawson, M. J. Caimano, and J. D. Radolf. 2001. The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity. J. Exp. Med. 193:1015-1026.
21. Higgins, S. P., A. Sukthankar, M. Mahto, R. R. Jarvis, and H. B. Lacey. 2000. Syphilis increases in Manchester, UK. Lancet 355:1466.
22. Hira, S. K., G. J. Bhat, A. V. Ratnam, S. L. Nyaywa, S. J. Phiri, L. M. Sandala, G. K. Kukelabai, R. C. Mulenga, I. Nyerenda, and N. Ng'andu. 1987. Maternal and congenital syphilis in Zambia-some epidemiologic aspects. Afr. J. Sex. Transm. Dis. 3:3-6.
23. Johns, D. R., M. Tiernewy, and D. Felsenstein. 1987. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. N. Engl. J. Med. 315:1569-1572.
24. Katz, D. A., and J. R. Berger. 1989. Neurosyphilis in acquired immunodeficiency syndrome. Arch. Neurol. 45:895-898.
25. Kreiss, J. K., R. Coombs, F. A. Plummer, K. K. Holmes, B. Nikora, W. Cameron, E. Ngugi, J. O. Ndinya Achola, and L. Corey. 1989. Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes. J. Infect. Dis. 160:380-384.
26. Kroll, D. J., H. Abdel-Malek Abdel-Hafiz, T. Marcell, S. Simpson, C. Y. Chen, A. Guiterrez-Hartmann, J. W. Lustbader, and J. P. Hoeffler. 1993. A multifunctional prokaryotic protein expression system: Overproduction, affinity purification, and selective detection. DNA Cell Biol. 12:441-453.
27. Liu, H., B. M. Steiner, J. D. Alder, D. K. Baertschy, and R. F. Schell. 1990. Immune T cells sorted by flow cytometry confer protection against infection with Treponema pallidum subsp. pertenue in hamsters. Infect. Immun. 58:1685-1690.
28. Lukehart, S. A., S. A. Baker-Zander, R. M. C. Lloyd, and S. Sell. 1980. Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions. J. Immunol. 124:461-467.
29. Lukehart, S. A., S. A. Baker-Zander, R. M. Lloyd, and S. Sell. 1981. Effect of cortisone administration on host-parasite relationships in early experimental syphilis. J. Immunol. 127:1361-1368.
30. Lukehart, S. A., S. A. Baker-Zander, and S. Sell. 1980. Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens. J. Immunol. 124:454-460.
31. Lukehart, S. A., and J. N. Miller. 1978. Demonstration of the in vitro phagocytosis of Treponema pallidum by rabbit peritoneal macrophages. J. Immunol. 121:2014-2024.
32. Magnuson, H. J., E. W. Thomas, S. Olansky, B. I. Kaplan, L. De Mello, and J. C. Cutler. 1956. Inoculation syphilis in human volunteers. Medicine 35:33-82.
33. McLeod, C. P., and H. J. Magnuson. 1956. Effect of cortisone on latent syphilis in rabbits and mice. J. Immunol. 76:373-376.
34. Metzger, M., E. Michalska, J. Podwinska, and W. Smogor. 1969. Immunogenic properties of the protein component of Treponema pallidum. Br. J. Vener. Dis. 45:299-303.
35. Miller, J. N. 1973. Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by gamma-irradiation. J. Immunol. 110:1206-1215.
36. Morgan, C. A., B. J. Molini, S. A. Lukehart, and W. C. Van Voorhis. 2002. Segregation of B and T cell epitopes of Treponema pallidum TprK to variable and conserved regions during experimental syphilis infection. J. Immunol. 169:952-957.
37. Panchaud, C. S. Singh, D. Feivelson, and J. E. Darroch. 2000. Sexually transmitted diseases among adolescents in developed countries. Fam. Plann. Perspect. 32:24-32, 45.
38. Plummer, F. A., M. A. Wainberg, P. Plourde, P. Jessamine, L. J. D'Costa, I. A. Wamola, and A. R. Ronald. 1990. Detection of human immunodeficiency virus type 1 (HIV-1) in genital ulcer exudates of HIV-1-infected men by culture and gene amplification. J. Infect. Dis. 161:810-811.
39. Renton, A. M., K. K. Borisenko, A. Meheus, and A. Gromyko. 1998. Epidemics of syphilis in the newly independent states of the former Soviet Union. Sex. Transm. Infect. 74:165-166.
40. Schell, R. F., J. K. Chan, and J. L. Le Frock. 1979. Endemic syphilis: Passive transfer of resistance with serum and cells in hamsters. J. Infect. Dis. 140:378-383.
41. Tani, T., R. Inoue, and O. Asano. 1951. Studies on the preventive inoculation against syphilis. Jpn. Med. J. 4:71-86.
42. Turner, T. B., and D. H. Hollander. 1954. Studies on the mechanism of action of cortisone in experimental syphilis. Am. J. Syph. Gonor. Vener. Dis. 38:371-387.
43. Turner, T. B., and D. H. Hollander. 1957. Biology of the treponematoses. World Health Organization, Geneva, Switzerland.
44. Van Voorhis, W. C., L. K. Barrett, D. M. Koelle, J. M. Nasio, F. A. Plummer, and S. A. Lukehart. 1996. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J. Infect. Dis. 173:491-495.
45. Wasserheit, J. N. 1991. Epidemiological synergy: Interrelationships between HIV infection and other STDs, p. 47-72. In L. C. Chen et al. (ed.), AIDS and women's reproductive health. Plenum Press, New York, N.Y.
46. Wicher, V., K. Wicher, A. Jakubowski, and S. M. Nakeeb. 1987. Adoptive transfer of immunity to Treponema pallidum Nichols infection in inbred strain 2 and C4D guinea pigs. Infect. Immun. 55:2502-2508.