Leptin Regulates Gallbladder Genes Related to Gallstone Pathogenesis in Leptin-Deficient Mice

Journal of the American College of Surgeons

Volumn 206, Issue 3, 2008, Pages 503-510

  Graewin, Shannon J ^a   Kiely, James M ^a   Lu, Debao ^b   Svatek, Carol L ^a   Al Azzawi, Hayder H ^b   Swartz Basile, Deborah A ^b   Pitt, Henry A ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BETA 2 ADRENERGIC RECEPTOR; CARBOXYLESTERASE; CHOLECYSTOKININ A RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; IMMUNOGLOBULIN HEAVY CHAIN; LEPTIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MUCIN 3; PROTEIN KINASE (CALCIUM,CALMODULIN); RECOMBINANT LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOWN REGULATION; FEMALE; GALLSTONE; GENE CONTROL; LIPID METABOLISM; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; UPREGULATION; WEIGHT REDUCTION;

ANIMALS; FEMALE; GALLBLADDER; GALLSTONES; LEPTIN; MICE; MICE, OBESE; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SIZE; RNA, MESSENGER; WEIGHT LOSS;

EID: 39649097402     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2007.09.015     Document Type: Article

References (29)

1. Mokdad A.H., Ford E.S., Bowman B.A., et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289 (2003) 76-92
2. Nakeeb A., Comouzzie A.G., Martin L., et al. Gallstones: genetics versus environment. Ann Surg 235 (2002) 842
3. Heymsfield S.B., Greenberg A.S., Fujioka K., et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose escalation trial. JAMA 282 (1999) 1568-1575
4. Jequier E. Leptin signaling, adiposity, and energy balance. Ann NY Acad Sci 967 (2002) 379-388
5. Goldblatt M.I., Swartz-Basile D.A., Svatek C.L., et al. Decreased gallbladder response in leptin-deficient obese mice. J Gastrointest Surg 6 (2002) 438-442
6. Phillips J., Tran K.Q., Goldblatt M.I., et al. Leptin ameliorates the gallbladder's response to neurotransmitters in congenitally obese mice. [abstract]. Gastroenterol 123 (2002) 9A
7. Swartz-Basile D.A., Graewin S.J., Svatek C.L., and Pitt H.A. Alimentary leptin receptors are most abundant in the gallbladder. [abstract]. J Am Coll Surg 199 (2004) 512
8. Tartaglia L.A., Dembski M., Weng X., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
9. Vaisse C., Halass J.L., Horvath C.M., et al. Leptin activation of Stat 3 in the hypothalamus of wildtype and ob/ob mice but not db/db mice. Nat Genet 14 (1996) 95-97
10. Ghilardi N., Ziegler S., Wiestner A., et al. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93 (1996) 6231-6235
11. Stengel P.W., and Cohen M.L. Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M2, M3, and M4 in carbamylcholine-induced gallbladder contractility. J Pharmacol Exp Ther 301 (2002) 643-650
12. Mawe G.M., Talmage E.K., Cornbrooks E.B., et al. Innervation of the gallbladder: structure, neurochemical coding, and physiological properties of guinea pig gallbladder ganglia. Micro Res Tech 39 (1997) 1-13
13. Hanyu N., Dodds W.J., Layman R.D., et al. Mechanism of cholecystokinin-induced contraction of the opossum gallbladder. Gastroenterology 98 (1990) 1299-1306
14. Grider J.R. Role of cholecystokinin in the regulation of gastrointestinal motility. J Nutr 124 (1994) 1334S-1339S
15. Yu P., Chen Q., Xiao Z., et al. Signal transduction pathways mediating CCK-induced gallbladder muscle contraction. Am J Physiol 275 (1998) G203-G209
16. Graewin S.J., Lee K.-H., Kiely J.M., et al. Gallbladder myocytes are short and CCK-resistant in obese diabetic mice. Surgery 136 (2004) 431-436
17. Bolton T.B., Prestwich S.A., Zholos A.V., and Gordienko D.V. Excitation-contraction coupling in gastrointestinal and other smooth muscles. Annu Rev Physiol 61 (1999) 85-115
18. Somlyo A.P., and Somlyo A.V. Signal transduction and regulation in smooth muscle. Nature 372 (1994) 231-236
19. Ahmed H.A., Petroni M.L., Abu-Hamidayyah M., et al. Hydrophobic/hydrophilic balance of proteins: A major determinant of cholesterol crystal formation in model bile. J Lipid Res 35 (1994) 211-219
20. Tran K.Q., Swartz-Basile D.A., Goldblatt M.I., et al. Carboxylesterase is a cholesterol crystal pronucleator in leptin-deficient obese mice. J Am Coll Surg 195 (2002) S13
21. Johnston S.M., Murray K.P., Martin S., et al. Iron deficiency enhances cholesterol gallstone formation. Surgery 122 (1997) 354-362
22. Lipsett P.A., Hildreth J., Kaufman H.S., et al. Human gallstones contain pronucleating nonmucin glycoproteins that are immunoglobulins. Ann Surg 219 (1994) 25-33
23. Hattori Y., Tazuma S., Yamashita G., and Kajiyama G. Influence of cholesterol crystallization effector proteins on vesicle fusion in supersaturated model bile. J Gastroenterol Hepatol 14 (1999) 669-674
24. Lammert F., Wang D.Q., Wittenburg H., et al. Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice. Hepatology 36 (2002) 1145-1154
25. Hyoto H., Roy S., Paigen B., and Cohen D.E. Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. J Biol Chem 277 (2002) 34117-34124
26. Swartz-Basile D.A., Goldblatt M.I., Choi S.-H., et al. Biliary lipids and cholesterol crystal formation in leptin-deficient obese mice. HPB 8 (2006) 386-392
27. Al-Azzawi H.H., Nakeeb A., Saxena R., et al. Steatocholecystitis: an explanation for increased cholecystectomy rates. J Gastrointest Surg 11 (2007) 835-843
28. Goldblatt M.I., Swartz-Basile D.A., Al-Azzawi H.H., et al. Nonalcoholic fatty gallbladder disease: the influence of diet in lean and obese mice. J Gastrointest Surg 10 (2006) 193-199
29. Chiang J.Y. Bile acid regulation of hepatic physiology III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol 284 (2003) G349-G356