Suppressing posttranslational gluconoylation of heterologous proteins by metabolic engineering of Escherichia coli

Applied and Environmental Microbiology

Volumn 74, Issue 4, 2008, Pages 950-958

  Aon, Juan C ^a   Caimi, Richard J ^a   Taylor, Alexander H ^a   Lu, Quinn ^a   Oluboyede, Femi ^a   Dally, Jennifer ^a   Kessler, Michelle D ^a   Kerrigan, John J ^a   Lewis, Tia S ^a   Wysocki, Lisa A ^a   Patel, Pramatesh S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCONOYLATION; METABOLIC FLUX ANALYSIS; METABOLIC PATHWAY ENGINEERING; PENTOSE PHOSPHATE PATHWAY; POSTTRANSLATIONAL MODIFICATION;

BIOMASS; CELL CULTURE; DNA; ESCHERICHIA COLI; METABOLISM;

PROTEINS;

BACTERIAL ENZYME; ELONGIN C; GLUCONOLACTONASE; LIVER X RECEPTOR; PENTOSE PHOSPHATE; PHOSPHOGLUCONOLACTONASE; PLASMID DNA; PROTEIN; PROTEIN PRECURSOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

BACTERIUM; BIOMASS; PHOSPHATE; PLASMID; PROTEIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOACCUMULATION; CELL DENSITY; CHEMICAL MODIFICATION; ESCHERICHIA COLI; FED BATCH CULTURE; GLUCONOYLATION; HETEROLOGOUS EXPRESSION; METABOLIC ENGINEERING; MICROBIAL BIOMASS; NONHUMAN; PRODUCTIVITY; PROTEIN INDUCTION; PROTEIN PROCESSING;

CARBOXYLIC ESTER HYDROLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; FLUOROMETRY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCONATES; MASS SPECTROMETRY; PROTEIN ENGINEERING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 39649092097     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.01790-07     Document Type: Article

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