Pennogenin glycosides with a spirostanol structure are strong platelet agonists: Structural requirement for activity and mode of platelet agonist synergism

Journal of Thrombosis and Haemostasis

Volumn 6, Issue 3, 2008, Pages 524-533

  Fu, Y L ^a   Yu, Z Y ^a   Tang, X M ^a   Zhao, Y ^a   Yuan, X L ^a   Wang, S ^a   Ma, B P ^a   Cong, Y W ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Paris polyphylla Sm. var. yunnanensis; Pennogenin glycosides; Platelet aggregation; Platelet agonists; Proaggregatory activity; Structure activity assay

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; APYRASE; COLLAGEN; CYCLIC AMP; EDETIC ACID; GLYCOPROTEIN; PERVANADATE; PHOSPHATIDYLINOSITOL 3 KINASE; PINNOGENIN GLYCOSIDE; PLANT GLYCOSIDE; PROSTAGLANDIN E1; SAPONIN; THROMBOXANE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; BLEEDING TIME; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENTIATION; DRUG PURIFICATION; DRUG STRUCTURE; EXTRACELLULAR CALCIUM; FLOW CYTOMETRY; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RHIZOME; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; UTERUS BLEEDING; WESTERN BLOTTING;

ANIMALS; BLEEDING TIME; BLOOD PLATELETS; CYCLIC AMP; GLYCOSIDES; MALE; MICE; MICE, INBRED BALB C; MODELS, CHEMICAL; PLATELET AGGREGATION; SAPONINS; SIGNAL TRANSDUCTION; SPIROSTANS; STEROIDS;

EID: 39549111019     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02881.x     Document Type: Article

References (29)

1. Flaumenhaft R. Molecular basis of platelet granule secretion. Arterioscler Thromb Vasc Biol 2003; 23: 1152-60.
2. Jackson SP, Nesbitt WS, Kulkarni S. Signaling events underlying thrombus formation. J Thromb Haemost 2003; 1: 1602-12.
3. Offermanns S. G-proteins as transducers in transmembrane signalling. Prog Biophys Mol Biol 2003; 83: 101-30.
4. Brass LF, Hoscie JA, Manning DR. Signalling through G proteins and G protein-coupled receptors during platelet activation. Thromb Haemost 1993; 70: 217-23.
5. Huang EM, Detwiler TC. Characteristics of the synergistic actions of platelet agonists. Blood 1981; 57: 685-91.
6. Sparg SG, Light ME, Staden JV. Biological activities and distribution of plant saponins. J Ethnopharmacol 2004; 94: 219-43.
7. Rao AV, Gurfinkel DM. The bioactivity of saponins: Triterpenoid and steroidal glycosides. Drug Metabol Drug Interact 2000; 17: 211-35.
8. Nohara T, Yabuta H, Suenobu M, Hida R, Miyahara K, Kawasaki T. Steroid glycosides in Paris polyphylla Sm. Chem Pharm Bull 1973; 21: 1240-7.
9. Chen CX, Zhang YT, Zhou J. Studies on the saponin components of plants in Yunnan: Steroid glycosides of Paris polyphylla var. yunnanensis. Yunnan Zhiwu Yanjiu 1983; 5: 91-7.
10. Chen CX, Zhou J. Two new steroid saponins of Paris polyphylla var. yunnanensis. Yunnan Zhiwu Yanjiu 1992; 14: 111-3.
11. Kang LP, Ma BP, Zhang J, Xiong CQ, Tan DW, Cong YW. Isolation and identification of steroidal saponins from Paris polyphylla Smith. Chinese J Med Chem 2005; 15: 25-30.
12. Tian Y, Zheng LH, Xu ZY, Sun LQ, Gao CK, Zheng QZ, Zhang ZH, Shu Y. Clinical and pharmacological study of the hemostatic action of rhizoma paridis by contraction of uterus. J Tradit Chin Med 1986; 6: 178-82.
13. Lee MS, Yuet-Wa JC, Kong SK, Yu B, Eng-Choon VO, Nai-Ching HW, Chung-Wai TM, Fung KP. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biol Ther 2005; 4: 1248-54.
14. Nambu T, Huang X, Shu Y, Huang S, Hattori M, Kakiuchi N, Wang Q, Yu GJ. Chronotropic effect of the methanolic extracts of the plants of the Paris species and steroidal glycosides isolated from P. vietnamensis on spontaneous beating of myocardial cells. Planta Med 1989; 55: 501-5.
15. Matsuda H, Pongpiriyadacha Y, Morikawa T, Kishi A, Kataoka S, Yoshikawa M. Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: Structural requirement for activity and mode of action. Bioorg Med Chem Lett 2003; 13: 1101-6.
16. Broze GJ Jr, Yin ZF, Lasky N. A tail vein bleeding time model and delayed bleeding in hemophiliac mice. Thromb Haemost 2001; 85: 747-8.
17. Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alpha IIb. J Biol Chem 2006; 281: 36732-41.
18. Wang WY, Wu YC, Wu CC. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor. Mol Pharmacol 2006; 70: 1380-9.
19. Yuan X, Cong Y, Hao J, Shan Y, Zhao Z, Wang S, Chen J. Regulation of LIP level and ROS formation through interaction of H-ferritin with G-CSF receptor. J Mol Biol 2004; 339: 131-44.
20. Levy-Toledano S, Gallet C, Nadal F, Bryckaert M, Maclouf J, Rosa JP. Phosphorylation and dephosphorylation mechanisms in platelet function: A tightly regulated balance. Thromb Haemost 1997; 78: 226-33.
21. Beatty CH, Howard CF, Caruso V. Potentiation with epinephrine of macaque platelet aggregation by other agonists: Implications for studies on human atherosclerosis. Thromb Res 1986; 41: 447-58.
22. Basani RB, D'Andrea G, Mitra N, Vilaire G, Richberg M, Kowalska MA, Bennett JS, Poncz M. RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb). J Biol Chem 2001; 276: 13975-81.
23. Shattil SJ, Brass LF, Bennett JS, Pandhi P. Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb -IIIa complex. Blood 1985; 66: 92-8.
24. Pietrocola G, Schubert A, Visai L, Torti M, Fitzgerald JR, Foster TJ, Reinscheid DJ, Speziale P. FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation. Blood 2005; 105: 1052-9.
25. Selheim F, Holmsen H, Vassbotn FS. PI3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation. Platelets 2000; 11: 69-82.
26. Zhang J, Meng Z, Zhang M, Ma D, Xu S, Kodama H. Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood. Clin Chim Acta 1999; 289: 79-88.
27. Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth 2005; 95: 130-9.
28. Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE. PAR4, but not PAR1, signals human platelet aggregation via Ca 2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem 2006; 281: 26665-74.
29. Nilsson UK, Svensson SP, Grenegard M. Synergistic activation of human platelets by lysophosphatidic acid and adrenaline. Haematologica 2002; 87: 730-9.