New method for the simultaneous estimation of intrinsic hepatic clearance and protein binding by matrix inhibition

Biopharmaceutics and Drug Disposition

Volumn 29, Issue 1, 2008, Pages 7-16

  Uchimura, Takahide ^a   Kato, Motohiro ^a   Tachibana, Tatsuhiko ^a   Arai, Shinichi ^a   Nabuchi, Yoshiaki ^a   Saito, Kimitoshi ^a   Kinoshita, Haruki ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Intrinsic hepatic clearance; Microsomes; Nonlinear least squares method; Protein binding; Serum

Indexed keywords

DIAZEPAM; IMIPRAMINE; WARFARIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SCREENING; EQUILIBRIUM DIALYSIS; LIVER CLEARANCE; LIVER MICROSOME; LIVER MICROSOME METABOLISM; METABOLIC RATE; NONHUMAN; PROCESS DEVELOPMENT; PROTEIN BINDING; RAT;

ADSORPTION; ALGORITHMS; ANIMALS; DIALYSIS; DIAZEPAM; IMIPRAMINE; LIVER; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PROTEIN BINDING; PROTEINS; RATS; SERUM; TRITIUM; WARFARIN;

EID: 39449129067     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.583     Document Type: Article

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