Reduced expression of the gap junction protein connexin 43 in keratoconus

Eye

Volumn 22, Issue 2, 2008, Pages 294-299

  Gatzioufas, Z ^a   Charalambous, P ^a   Thanos, S ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; GAP JUNCTION PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATOCONUS; MALE; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

EID: 39449109166     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/sj.eye.6702972     Document Type: Article

References (35)

1. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42(4): 297-319.
2. Kennedy RH, Bourne WM, Dyer JA. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 1986; 101: 267-273.
3. Kenney MC, Brown DJ, Rajeev B. Everett Kinsey lecture. The elusive causes of keratoconus: A working hypothesis. CLAO J 2000; 26 1): 10-13.
4. Meek KM, Tuft SJ, Huang Y, Gill PS, Hayes S, Newton RH et al. Changes in collagen orientation and distribution in keratocomis corneas. Invest Ophthalmol Vis Sci 2005; 46(6): 1948-1956.
5. Kumar NM, Gilula NB. The gap junction communication channel. Cell 1996; 84: 381-388.
6. Simon AM, Goodenough DA. Diverse functions of vertebrate gap junctions. Trends Cell Biol 1998; 8: 477-483.
7. Shibata Y, Kumai M, Nishii K, Nakamura K. Diversity and molecular anatomy of gap junctions. Med Electron Microsc 2001; 34: 153-159.
8. Dong Y, Roos M, Gruijters T, Donaldson P, Bullivant S, Beyer E et al Differential expression of two gap junction proteins in corneal epithelium. Eur J Cell Biol 1994; 64: 95-100.
9. Spanakis SG, Petridou S, Masur SK. Functional gap junctions in corneal fibroblasts and myofibroblasts. Invest Ophthalmol Vis Sci 1998; 39: 1320-1328.
10. Lampe PD, Tenbroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF. Phosphorylation of connexin 43 on serine 368 by protein kinase C regulates gap junctional communication. J Cell Biol 2000; 149 7): 1503-1512.
11. Solan JL, Lampe PD. Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. Biochim Biophys Acta 2005; 1711(2): 154-163.
12. Nagase H, Woessner Jr JF. Matrix metalloproteinase. J Biol Chem 1999; 274(31): 21491-21494.
13. Brown D, Chwa MM, Opbroek A, Kenney MC. Keratoconus corneas. Increased gelatinase activity appears after modification of inhibitors. Curr Eye Res 1993; 12: 571-581.
14. Kenney MC, Chwa M, Opbroek AJ, Brown DJ. Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio. Cornea 1994; 13: 114-124.
15. Zhou L, Sawaguchi S, Twinning SS, Sugar J, Feder RS, Yue BY. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest Ophthalmol Vis Sci 1998; 39(7): 1117-1124.
16. Sawaguchi S, Twining SS, Yue BY, Chong SH, Zhou X, Loushin G et al Alpha 2-macroglobulin levels in normal human and keratoconus corneas. Invest Ophthalmol Vis Sci 1994; 35(12): 4008-4014.
17. Whitelock RB, Fukuchi T, Zhou L, Twining SS, Sugar J, Feder RS et al Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas. Invest Ophthalmol Vis Sci 1997; 38(2): 529-534.
18. Maruyama Y, Wang X, Li Y, Sugar J, Yue BY. Involvement of Sp 1 elements in the promoter activity of genes affected in keratoconus. Invest Ophthalmol Vis Sci 2001; 42(9): 1980-1985.
19. Alabain JH, Dossou H, Colin J, Floch HH. Levels of collagen degradation products (telopeptides) in the tear film of patients with keratoconus. Cornea 2000; 19(4): 474-476.
20. Matic M, Petrov IN, Chen S. Stem cells of the corneal epithelium lacks connexins and metabolite transfer capacity. Differentiation 1997; 61: 251-260.
21. Wolosin JM, Budak MT, Akinci MA. Ocular surface epithelial and stem cell development. Int J Dev Biol 2004; 48(8-9): 981-991.
22. Hao JL, Suzuki K, Lu Y, Hirano S, Fukuda K, Kumagai N et al. Inhibition of gap junction-mediated intercellular communication by TNF-a in cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005; 46(4): 1195-1200.
23. Anderson SC, Stone C, Tkach L, SundarRaj N. Rho and Rho-kinase (ROCK) signalling in adherens and gap junction assembly in corneal epithelium. Invest Ophthalmol Vis Sci 2002; 43(4): 978-986.
24. Cruciani V, Mikalsen SO. Connexins, gap junctional intercellular communication and kinases. Biol Cell 2002; 94: 433-443.
25. Saez JC, Retamal MA, Basilio D, Bukauskas FF, Bennett MVL. Connexin-based gap junctions hemichannels: Gating mechanisms. Biochim Biophys Acta 2005; 1711: 215-224.
26. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H et al Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 2002; 8: 500-508.
27. Aronica E, Gorter JA, Jansen GH, Leenstra S, Yankaya B, Troost D. Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol (Berlin) 2001; 101(5): 449-459.
28. Loring JF, Wen X, Lee JM, Seilhamer J, Somogyi R. A gene expression profile of Alzheimer's diease. DNA Cell Biol 2001; 20: 683-695.
29. Paznekas WA, Boyadjiev SA, Shapiro RE, Daniels O, Wollnik B, Keegan CE et al. Connexin 43 (GJA1) mutations cause a pleiotropic phenotype of oculodentodigital dysplasia. Am J Hum Genet 2003; 72: 408-418.
30. Cella W, de Vasconcellos JP, de Melo MB, Kneipp B, Costa FF, Longui CA et al. Structural assessment of PITX2, FOXC1, CYP1B1, and GJA1 genes in patients with Axenfeld-Rieger syndrome with developmental glaucoma. Invest Ophthalmol Vis Sci 2006; 47(5): 1803-1809.
31. Hughes AF, Posh DP, Jackson AJ, Frazer DG, Silvestri G. Familial keratoconus with cataract: Linkage to the long arm of chromosome 15 and exclusion of candidate genes. Invest Ophth Vis Sci 2003; 44 12): 5063-5066.
32. Reaume AG, de Sousa PA, Kulliarni S, Langille BL, Zhu D, Davies TC et al. Cardiac malformation in neonatal mice lacking connexin 43. Science 1995; 267: 1831-1834.
33. Ya J, Erdtsieck-Ernste EBHW, de Boer PA, van Kempen MJ, Jongsma H, Moorman AF et al. Heart defects in Connexin43-deficient mice. Circ Res 1998; 82: 360-366.
34. Risley MS, Tan IP, Farrell J. Gap junctions with varied permeability properties establish cell-type specific communication pathways in the rat seminiferous epithelium. Biol Reprod 2002; 67: 945-952.
35. Montecino-Rodriguez E, Leathers H, Dorshkind K. Expression of connexin 43 (Cx43) is critical for normal hematopoiesis. Blood 2000; 96 917-924.