Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex

Acta Neuropathologica

Volumn 101, Issue 5, 2001, Pages 449-459

  Aronica, Eleonora ^a,b   Gorter, Jan A ^a,b   Jansen, Gerard H ^c   Leenstra, Sieger ^a   Yankaya, Bulent ^a   Troost, Dirk ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Brain tumors; Connexin proteins; Epilepsy; Gap junctions; Peritumoral astrocytes

Indexed keywords

CONNEXIN 32; CONNEXIN 43; GAP JUNCTION PROTEIN;

ARTICLE; ASTROCYTE; ASTROCYTOMA; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN REGION; BRAIN SURGERY; BRAIN TUMOR; CANCER GRADING; CELL MEMBRANE; CHRONIC DISEASE; CONTROLLED STUDY; EPILEPSY; GLIOMA; GLIOSIS; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; OLIGODENDROGLIA; OLIGODENDROGLIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; STAINING; SYNCYTIUM; TERATOMA; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION;

ASTROCYTES; ASTROCYTOMA; BRAIN NEOPLASMS; CELL COMMUNICATION; CEREBRAL CORTEX; CONNEXIN 43; CONNEXINS; EPILEPSY; GANGLIOGLIOMA; GAP JUNCTIONS; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; NEUROCYTOMA; NEUROFILAMENT PROTEINS; NEURONS; OLIGODENDROGLIOMA; PHOSPHOPYRUVATE HYDRATASE; SYNAPSINS; SYNAPTOPHYSIN; VIMENTIN;

EID: 0034950760     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010000305     Document Type: Article

References (68)

1. Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy
2. Gap junctions: New tools, new answers, new questions
3. Gap junctions
4. Connexin43: A protein from rat heart homologous to a gap junction protein from liver
5. Electrophysiological properties of human astrocytic tumor cells in situ: Enigma of spiking glial cells
6. Properties of human glial cells associated with epileptic seizure foci
7. Connections with connexins: The molecular basis of direct intercellular signaling
8. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons
9. Intermediate filaments in nervous tissue
10. Neuronal activity triggers calcium waves in hippocampal astrocyte networks
11. The gap junction channel
12. Gap junctions in the brain: Where, what type, how many and why?
13. Differential expression of three gap junction proteins in developing and mature brain tissues
14. + concentration
15. Connexins are expressed in primary brain tumors and enhance the bystander effect in gene therapy
16. Gap junctions in brain glial cells and development
17. Brain glia release factors with opposing actions upon neuronal survival
18. Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas
19. Astroglia in CNS injury
20. Phosphorylated forms of connexin43 predominate in rat brain: Demonstration by rapid inactivation of brain metabolism
21. Ischemia-induced cellular redistribution of the astrocytic gap junctional protein connexin43 in rat brain
22. Reduced connexin43 expression in high-grade human brain glioma cells
23. Astrocytes in kindling: Relevance to epileptogenesis
24. The new WHO classification of brain tumours
25. Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32
26. The gap junction communication channel
27. Action potential-generating cells in human glioblastomas
28. Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells
29. The early reactions of non-neuronal cells to brain injury
30. Gap junction messenger RNA expression by vascular wall cells
31. Human epileptic astrocytes exhibit increased gap junction coupling
32. Gap-junction-mediated propagation and amplification of cell injury
33. The cell-to-cell channel of gap junctions
34. Loss of inhibitory synapses on the soma and axon initial segment of pyramidal cells in human epileptic peritumoural neocortex: Implications for epilepsy
35. Distribution of mRNAs coding for liver and heart gap junction proteins in the rat central nervous system
36. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques
37. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines
38. Gap junction-mediated communication in the developing and adult cerebral cortex
39. Gap junctions in the adult cerebral cortex: Regional differences in their distribution and cellular expression of connexins
40. Expression of gap junction genes in astrocytes and C6 glioma cells
41. Gap junction gene expression in human seizure disorder
42. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells
43. Astrocyte responses to CNS injury
44. Astrocytic gap junction removal, connexin43 redistribution, and epitope masking at excitatory amino acid lesion sites in rat brain
45. Connexin-43 in rat spinal cord: Localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions
46. Astrocytes from human hippocampal epileptogenic foci exhibit action potential-like responses
47. Glutamate-mediated astrocyte-neuron signalling
48. A monoclonal antibody against vimentin: Characterization
49. Facial nerve lesions lead to increased immunostaining of the astrocytic gap junction protein (connexin 43) in the corresponding facial nucleus of rats
50. Regulation of gap junctions by protein phosphorylation
51. Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA
52. Protein and messenger RNA expression of connexin43 in astrocytomas: Implications in brain tumor gene therapy
53. Gap junction protein in rat hippocampus: Correlative light and electron microscope immunohistochemical localization
54. Diverse functions of vertebrate gap junctions
55. Measurement of protein using bicinchoninic acid
56. Molecular physiology of gap junction channels
57. Gap junctions in glia. Types, roles, and plasticity
58. Hyperexcitability associated with localizable lesions in epileptic patients
59. Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury
60. Genetic diseases and gene knockouts reveal diverse connexin functions
61. Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues
62. Neurochemical profile of glioneuronal lesions from patients with pharmacoresistant focal epilepsies
63. Neural antigens in oligodendrogliomas and dysembryoplastic neuroepithelial tumors
64. LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain
65. Intercellular communication and carcinogenesis
66. Role of connexin (gap junction) genes in cell growth control and carcinogenesis
67. Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain. Expression of endothelin-like immunoreactivity in reactive astrocytes and activation of microglial cells
68. Direct gap junction communication between malignant glioma cells and astrocytes