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Volumn 1, Issue SUPPL.1, 2008, Pages

The role of the calcium-sensing receptor in the pathophysiology of secondary hyperparathyroidism

Author keywords

Calcium sensing receptor; Chronic kidney disease; Cinacalcet; Parathyroid hormone; Secondary hyperparathyroidism

Indexed keywords

CALCIMIMETIC AGENT; CALCIUM SENSING RECEPTOR; CINACALCET; G PROTEIN COUPLED RECEPTOR; GADOLINIUM; MAGNESIUM ION; NEOMYCIN; R 568; SPERMINE; UNCLASSIFIED DRUG;

EID: 39349099289     PISSN: 17530784     EISSN: 17530792     Source Type: Journal    
DOI: 10.1093/ndtplus/sfm038     Document Type: Conference Paper
Times cited : (22)

References (46)
  • 1
    • 0027765508 scopus 로고
    • Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    • Brown EM, Gamba G, Riccardi D et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-580
    • (1993) Nature , vol.366 , pp. 575-580
    • Brown, E.M.1    Gamba, G.2    Riccardi, D.3
  • 2
    • 0029055771 scopus 로고
    • Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs
    • Garrett JE, Capuano IV, Hammerland LG et al. Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem 1995; 270: 12919-12925
    • (1995) J Biol Chem , vol.270 , pp. 12919-12925
    • Garrett, J.E.1    Capuano, I.V.2    Hammerland, L.G.3
  • 3
    • 0028924833 scopus 로고
    • Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor
    • Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert SC. Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 1995; 92: 131-135
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 131-135
    • Riccardi, D.1    Park, J.2    Lee, W.S.3    Gamba, G.4    Brown, E.M.5    Hebert, S.C.6
  • 4
    • 0037650260 scopus 로고    scopus 로고
    • The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
    • Brauner-Osborne H, Jensen AA, Sheppard PO, O'Hara P, Krogsgaard-Larsen P. The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain. J Biol Chem 1999; 274: 18382-18386
    • (1999) J Biol Chem , vol.274 , pp. 18382-18386
    • Brauner-Osborne, H.1    Jensen, A.A.2    Sheppard, P.O.3    O'Hara, P.4    Krogsgaard-Larsen, P.5
  • 5
    • 0030612562 scopus 로고    scopus 로고
    • 2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells
    • 2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells. J Bone Miner Res 1997; 12: 715-725
    • (1997) J Bone Miner Res , vol.12 , pp. 715-725
    • Kifor, O.1    Diaz, R.2    Butters, R.3    Brown, E.M.4
  • 6
    • 0035001612 scopus 로고    scopus 로고
    • Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
    • Kifor O, MacLeod RJ, Diaz R et al. Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. Am J Physiol Renal Physiol 2001; 280: F291-F302
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Kifor, O.1    MacLeod, R.J.2    Diaz, R.3
  • 7
    • 0038125588 scopus 로고    scopus 로고
    • Extracellular calcium sensing and signalling
    • Hofer AM, Brown EM Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 2003; 4: 530-538
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 530-538
    • Hofer, A.M.1    Brown, E.M.2
  • 8
    • 0032584086 scopus 로고    scopus 로고
    • Calcimimetics with potent and selective activity on the parathyroid calcium receptor
    • Nemeth EF, Steffey ME, Hammerland LG et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci USA 1998; 95: 4040-4045
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4040-4045
    • Nemeth, E.F.1    Steffey, M.E.2    Hammerland, L.G.3
  • 9
    • 0023654485 scopus 로고
    • 2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor
    • 2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. J Biol Chem 1987; 262: 5188-5196
    • (1987) J Biol Chem , vol.262 , pp. 5188-5196
    • Nemeth, E.F.1    Scarpa, A.2
  • 10
    • 0033574418 scopus 로고    scopus 로고
    • Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor
    • Goldsmith PK, Fan GF, Ray K et al. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. J Biol Chem 1999; 274: 11303-11309
    • (1999) J Biol Chem , vol.274 , pp. 11303-11309
    • Goldsmith, P.K.1    Fan, G.F.2    Ray, K.3
  • 12
    • 27844587815 scopus 로고    scopus 로고
    • 2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor
    • 2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor. J Biol Chem 2005; 280: 37917-37923
    • (2005) J Biol Chem , vol.280 , pp. 37917-37923
    • Silve, C.1    Petrel, C.2    Leroy, C.3
  • 15
    • 0034718925 scopus 로고    scopus 로고
    • Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
    • Kunishima N, Shimada Y, Tsuji Y et al. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 2000; 407: 971-977
    • (2000) Nature , vol.407 , pp. 971-977
    • Kunishima, N.1    Shimada, Y.2    Tsuji, Y.3
  • 16
    • 83055172414 scopus 로고    scopus 로고
    • K/DOQI Guidelines. 2003. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003; 42: S1-S201
    • K/DOQI Guidelines. 2003. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003; 42: S1-S201
  • 17
    • 12144285037 scopus 로고    scopus 로고
    • The calcium-sensing receptor: A key factor in the pathogenesis of secondary hyperparathyroidism
    • Rodriguez M, Nemeth E, Martin D. The calcium-sensing receptor: A key factor in the pathogenesis of secondary hyperparathyroidism. Am J Physiol 2005; 288: F253-F264
    • (2005) Am J Physiol , vol.288
    • Rodriguez, M.1    Nemeth, E.2    Martin, D.3
  • 18
    • 0032949578 scopus 로고    scopus 로고
    • Mechanism of parathyroid tumourigenesis in uraemia
    • Tominaga Y. Mechanism of parathyroid tumourigenesis in uraemia. Nephrol Dial Transplant 1999; 14(Suppl 1): 63-65
    • (1999) Nephrol Dial Transplant , vol.14 , Issue.SUPPL. 1 , pp. 63-65
    • Tominaga, Y.1
  • 19
    • 0028858407 scopus 로고
    • Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D
    • Naveh-Many T, Rahamimov R, Livni N, Silver J. Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J Clin Invest 1995; 96: 1786-1793
    • (1995) J Clin Invest , vol.96 , pp. 1786-1793
    • Naveh-Many, T.1    Rahamimov, R.2    Livni, N.3    Silver, J.4
  • 20
    • 0029887094 scopus 로고    scopus 로고
    • Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro
    • Slatopolsky E, Finch J, Denda M et al. Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro. J Clin Invest 1996; 97: 2534-2540
    • (1996) J Clin Invest , vol.97 , pp. 2534-2540
    • Slatopolsky, E.1    Finch, J.2    Denda, M.3
  • 21
    • 0034747063 scopus 로고    scopus 로고
    • p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium
    • Cozzolino M, Lu Y, Finch J, Slatopolsky E, Dusso AS. p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium. Kidney Int 2001; 60:2109-2117
    • (2001) Kidney Int , vol.60 , pp. 2109-2117
    • Cozzolino, M.1    Lu, Y.2    Finch, J.3    Slatopolsky, E.4    Dusso, A.S.5
  • 22
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi Y, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805-816
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, Y.4    Elledge, S.J.5
  • 23
    • 0027513590 scopus 로고
    • Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
    • Pagano M, Pepperkok R, Lukas J et al. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol 1993; 121: 101-111
    • (1993) J Cell Biol , vol.121 , pp. 101-111
    • Pagano, M.1    Pepperkok, R.2    Lukas, J.3
  • 24
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura I, Denissova WG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004; 430: 226-231
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1    Denissova, W.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 25
    • 3042645056 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D downregulation of TGFalpha/EGFR expression and growth signaling: A mechanism for the antiproliferative actions of the sterol in parathyroid hyperplasia of renal failure
    • Dusso A, Cozzolino M, Lu Y, Sato T, Slatopolsky E. 1,25-Dihydroxyvitamin D downregulation of TGFalpha/EGFR expression and growth signaling: A mechanism for the antiproliferative actions of the sterol in parathyroid hyperplasia of renal failure. J Steroid Biochem Mol Biol 2004; 89-90: 507-511
    • (2004) J Steroid Biochem Mol Biol
    • Dusso, A.1    Cozzolino, M.2    Lu, Y.3    Sato, T.4    Slatopolsky, E.5
  • 26
    • 0035094077 scopus 로고    scopus 로고
    • p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth
    • Dusso AS, Pavlopoulos T, Naumovich L et al. p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth. Kidney Int 2001; 59: 855-865
    • (2001) Kidney Int , vol.59 , pp. 855-865
    • Dusso, A.S.1    Pavlopoulos, T.2    Naumovich, L.3
  • 27
    • 0033781819 scopus 로고    scopus 로고
    • The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis
    • Canalejo A, Almaden Y, Torregrosa V et al. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J Am Soc Nephrol 2000; 11: 1865-1872
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1865-1872
    • Canalejo, A.1    Almaden, Y.2    Torregrosa, V.3
  • 28
    • 0034778610 scopus 로고    scopus 로고
    • Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor
    • Ritter CS, Finch JL, Slatopolsky EA, Brown AJ. Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor. Kidney Int 2001; 60: 1737-1744
    • (2001) Kidney Int , vol.60 , pp. 1737-1744
    • Ritter, C.S.1    Finch, J.L.2    Slatopolsky, E.A.3    Brown, A.J.4
  • 29
    • 0032918925 scopus 로고    scopus 로고
    • Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate
    • Brown AJ, Ritter CS, Finch JL, Slatopolsky EA. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. Kidney Int 1999; 55: 1284-1292
    • (1999) Kidney Int , vol.55 , pp. 1284-1292
    • Brown, A.J.1    Ritter, C.S.2    Finch, J.L.3    Slatopolsky, E.A.4
  • 30
    • 0029873489 scopus 로고    scopus 로고
    • 2+-sensing receptor in primary and uremic secondary hyperparathyroidism
    • 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 1598-1606
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1598-1606
    • Kifor, O.1    Moore, F.D.2    Wang, P.3
  • 31
    • 27744578945 scopus 로고    scopus 로고
    • Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyrdid glands from humans
    • Canadillas S, Canalejo A, Santamaria R et al. Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyrdid glands from humans. J Am Soc Nephrol 2005; 16: 2190-2197
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2190-2197
    • Canadillas, S.1    Canalejo, A.2    Santamaria, R.3
  • 32
    • 0031042732 scopus 로고    scopus 로고
    • Depressed expression of calcium receptor in parathyroid gland tissue of patients with. hyperparathyroidism
    • Gogusev J, Duchambon P, Hory B et al. Depressed expression of calcium receptor in parathyroid gland tissue of patients with. hyperparathyroidism. Kidney Int 1997; 51: 328-336
    • (1997) Kidney Int , vol.51 , pp. 328-336
    • Gogusev, J.1    Duchambon, P.2    Hory, B.3
  • 34
    • 31144473816 scopus 로고    scopus 로고
    • Pharmacological and clinical properties of calcimimetics: Calcium receptor activators that afford an innovative apprbach to controlling hyperparathyroidism
    • Nagano N. Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative apprbach to controlling hyperparathyroidism. Pharmacol Ther 2006; 109: 339-365
    • (2006) Pharmacol Ther , vol.109 , pp. 339-365
    • Nagano, N.1
  • 35
    • 9144251958 scopus 로고    scopus 로고
    • Pharmacodynamics of the type JJ calcimimetic compound cinacalcet HCl
    • Nemeth EF, Heaton WH, Miller M et al. Pharmacodynamics of the type JJ calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther 2004; 308: 627-635
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 627-635
    • Nemeth, E.F.1    Heaton, W.H.2    Miller, M.3
  • 36
    • 1442301537 scopus 로고    scopus 로고
    • Calcimimetic and calcilytic drugs: Just for parathyroid cells?
    • Nemeth EF. Calcimimetic and calcilytic drugs: Just for parathyroid cells? Cell Calcium 2004; 35: 283-289
    • (2004) Cell Calcium , vol.35 , pp. 283-289
    • Nemeth, E.F.1
  • 37
    • 0022971152 scopus 로고
    • Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat
    • Silver J, Naveh-Many T, Mayer H, Schmelzer HJ, Popovtzer MM. Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest 1986; 78: 1296-1301
    • (1986) J Clin Invest , vol.78 , pp. 1296-1301
    • Silver, J.1    Naveh-Many, T.2    Mayer, H.3    Schmelzer, H.J.4    Popovtzer, M.M.5
  • 38
    • 0031964813 scopus 로고    scopus 로고
    • Regulation of the parathyroid hormone gene by calcium, phosphate and 1,25-dihydroxyvitamin D
    • Silver J, Moallem E, Kilav, R, Sela A, Naveh-Many T. Regulation of the parathyroid hormone gene by calcium, phosphate and 1,25-dihydroxyvitamin D. Nephrol Dial Transplant 1998; 13(Suppl 1): 40-44
    • (1998) Nephrol Dial Transplant , vol.13 , Issue.SUPPL. 1 , pp. 40-44
    • Silver, J.1    Moallem, E.2    Kilav, R.3    Sela, A.4    Naveh-Many, T.5
  • 39
    • 0025053995 scopus 로고
    • Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat
    • Naveh-Many T, Silver J. Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Clin Invest 1990; 86: 1313-1319
    • (1990) J Clin Invest , vol.86 , pp. 1313-1319
    • Naveh-Many, T.1    Silver, J.2
  • 40
    • 0032570574 scopus 로고    scopus 로고
    • RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate
    • Moallem E, Kilav R, Silver J, Naveh-Many T. RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998; 273: 5253-5259
    • (1998) J Biol Chem , vol.273 , pp. 5253-5259
    • Moallem, E.1    Kilav, R.2    Silver, J.3    Naveh-Many, T.4
  • 41
    • 0031888842 scopus 로고    scopus 로고
    • A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Rapid communication
    • Antonsen JE, Sherrard DJ, Andress DL. A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Rapid communication. Kidney Int 1998; 53: 223-227
    • (1998) Kidney Int , vol.53 , pp. 223-227
    • Antonsen, J.E.1    Sherrard, D.J.2    Andress, D.L.3
  • 42
    • 12344277590 scopus 로고    scopus 로고
    • Cinacticet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism
    • Colloton M, Shatzen E, Miller G et al. Cinacticet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int 2005; 67: 467-476
    • (2005) Kidney Int , vol.67 , pp. 467-476
    • Colloton, M.1    Shatzen, E.2    Miller, G.3
  • 43
    • 33745620444 scopus 로고    scopus 로고
    • Direct in vitro evidence of the suppressive effect of cinacalcet HCl onparathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels
    • Kawata T, Imanishi Y, Kobayashi K et al. Direct in vitro evidence of the suppressive effect of cinacalcet HCl onparathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels. J Bone Miner Melab 2006; 24: 300-306
    • (2006) J Bone Miner Melab , vol.24 , pp. 300-306
    • Kawata, T.1    Imanishi, Y.2    Kobayashi, K.3
  • 44
    • 19544367799 scopus 로고    scopus 로고
    • No effect of renal function or dialysis on pharmacokinetics of cinacalcet (Sensipar/Mimpara)
    • Padhi D, Han is RZ, Salfi M, Sullivan JT. No effect of renal function or dialysis on pharmacokinetics of cinacalcet (Sensipar/Mimpara). Clin Pharmacokinet 2005; 44: 509-516
    • (2005) Clin Pharmacokinet , vol.44 , pp. 509-516
    • Padhi, D.1    Han is, R.Z.2    Salfi, M.3    Sullivan, J.T.4
  • 45
    • 16644401755 scopus 로고    scopus 로고
    • Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency
    • Mizobuchi M, Hatanium I. Ogata H et al. Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency. J Am Soc Nephrol 2004; 15: 2579-2587
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2579-2587
    • Mizobuchi, M.1    Hatanium, I.2    Ogata, H.3
  • 46
    • 35348945723 scopus 로고    scopus 로고
    • Cinacalcet HCl increases expression of p21 in the parathyroid and reversibly inhibits parathyroid hyperplasia in a rodent model of CKD (Abstract)
    • Davis J, Miller J. Shatzen E, Henley C, Martin D. Cinacalcet HCl increases expression of p21 in the parathyroid and reversibly inhibits parathyroid hyperplasia in a rodent model of CKD (Abstract). Nephrol Dial Transplant 2005; 20: V205
    • (2005) Nephrol Dial Transplant , vol.20 , Issue.V205
    • Davis, J.1    Miller, J.2    Shatzen, E.3    Henley, C.4    Martin, D.5


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