4-tert-octylphenol regulates the differentiation of C3H10T1/2 cells into osteoblast and adipocyte lineages

Toxicological Sciences

Volumn 102, Issue 1, 2008, Pages 82-88

  Miyawaki, Joji ^a,b   Kamei, Setsuya ^a,b   Sakayama, Kenshi ^a   Yamamoto, Haruyasu ^a   Masuno, Hiroshi ^b  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

Author keywords

4 tert octylphenol; Adipocyte differentiation; C3H10T1 2 cells; Osteoblast differentiation

Indexed keywords

4 TERT OCTYLPHENOL; ADIPONECTIN; ALKALINE PHOSPHATASE; DEXAMETHASONE; INSULIN; ISOBUTYLMETHYLXANTHINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINEAGE; CELL STRUCTURE; CONNECTIVE TISSUE; CONTROLLED STUDY; EMBRYO; EMBRYONAL TISSUE; ENZYME INHIBITION; ESTROGEN ACTIVITY; INCUBATION TIME; MITOSIS INHIBITION; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; OSTEOBLAST; OSTEOCYTE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION;

ADIPOCYTES; ADIPONECTIN; ALKALINE PHOSPHATASE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL SHAPE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; EPOXY COMPOUNDS; MICE; MICE, INBRED C3H; MULTIPOTENT STEM CELLS; OSTEOBLASTS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PHENOLS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA2; TRIGLYCERIDES; WATER POLLUTANTS, CHEMICAL;

EID: 39149121853     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm296     Document Type: Article

References (36)

1. Abraham, E. J., and Frawley, L. S. (1997). Octylphenol (OP), an environmental estrogen, stimulates prolactin (PRL) gene expression. Life Sci. 60, 1457-1465.
2. Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., et al. (2004). PPARr insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J. Clin. Invest. 113 846-855.
3. Ali, A. A., Weinstein, R. S., Stewart, S. A., Parfitt, A. M., Monolagas, S. C., and Jilka, R. L. (2005). Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146, 1226-1235.
4. Beard, J., Marshall, S., Jong, K., Newton, R., Triplett-McBride, T., Humphries, B., and Brooks, R. (2000). 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)-ethane (DDT) and reduced bone mineral density. Arch. Environ. Health 55, 177-180.
5. Bellows, C. G., Aubin, J. E., and Heersche, J. N. M. (1991). Initiation and progression of mineralization of bone nodules formed in vitro - the role of alkaline-phosphatase and organic phosphate. Bone Miner. 14, 27-40.
6. Beresford, J. N., Bennett, J. H., Devlin, C., Laboy, P., and Owen, M. E. (1992). Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic ceils in rat marrow stromal cell cultures. J. Cell. Sci. 102, 341-351.
7. Chawla, P., Schwarz, A., Dimaculangan, D. D., and Lazar, M. A. (1994). Peroxisome proliferator-activated receptor r (PPARr): Adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135, 798-800.
8. Combs, T. P., Wagner, J. A., Berger, J., Doebber, T., Wang, W.-J., Zhang, B. B., Tanen, M., Berg, A. H., O rahilly. S., Savage, D. B., et al. (2002). Induction of adipocyte complement-related protein of 30 kilodaltons by PPARr agonists: A potential mechanism of insulin sensitization. Endocrinology 143, 998-1007.
9. Cornelius, P., MacDougald, O. A., and Lane, M. D. (1994). Regulation of adipocyte development. Annu. Rev. Nutr. 14, 99-129.
10. Dodge, J. A., Glasebrook, A. L., Magee, D. E., Phillips, D. L., Sato, M., Short, L. L., and Bryant, H. U. (1996). Environmental estrogens: Effects on cholesterol lowering and bone in the ovariectomized rat. J. Steroid Biochem. Mol. Biol. 59, 155-161.
11. Gazit, D., Ebner, R., Kahn, A. J., and Derynck, R. (1993). Modulation of expression and cell surface binding of members of the transforming growth factor-β saperfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol. Endocrinol. 7, 189-198.
12. Genge, B. R., Sauer, G. R., Wu, L. N. Y., McLean, F. M., and Wuthier, R. E. (1988). Correlation between loss of alkaline-phosphatase activity and accumulation of calcium during matrix vesicle-mediated mineralization. J. Biol. Chem. 263, 18513-18519.
13. Giger, W., Brunnen, P. H., and Schaffer, C. (1984). 4-Nonylphenol in sewage sludge: Accumulation of toxic metabolites from nonionic surfactants. Science 225, 623-625.
14. Gregoire, F. M., Sams, C. M., and Sul, H. S. (1998). Understanding adipocyte differentiation. Physiol. Rev. 78, 783-809.
15. Hernando, M. D., Mezcua, M., Gómez, M. J., Malato, O., Agüera, A., and Fernández-Alba, A. R. (2004). Comparative study of analytical methods involving gas chromatography-mass spectrometry for the determination of gas chromatography-tandem mass spectrometry for the determination of selected endocrine disrupting compounds in wastewaters. J. Chromatoogr. A. 1047, 129-135.
16. Hinegardner, R. T. (1971). An improved fluorometric assay for DNA. Anal. Biochem. 39, 197-201.
17. Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishisma, M., and Shimomura, I. (2003). Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655-1663.
18. Kanno, S., Hirano, S., and Kayama, F. (2004) Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells: Toxicology 196, 137-145.
19. Kuch, H. M., and Ballschmiter, K. (2001). Determination of endocrine-disrupting phenolic compounds and estrogens in surface and drinking water by HRGC-(NCI)-MS in the pictogram per liter range. Environ. Sci. Technol. 35, 3201-3206.
20. Kuri-Harcuch, W., and Green, H. (1978). Adipose conversion of 3T3 cells depends on a serum factor. Proc. Natl. Acad. Sci. USA. 75, 6107-6109.
21. Kwack, S. J., Kwon, O., Kim, H. S., Kim, S. S., Kim, S. H., Sohn, K. H., Lee, R. D., Park, C. H., Jeung, E. B., An, B. S., et al. (2002). Comparative evaluation of alkylphenolic compounds on estrogenic activity in vitro and in vivo. J. Toxicol. Environ. Health A 65, 419-431.
22. Laws, S. C., Carey, S. A., Ferrell, J. M., Bodman, G. J., and Cooper, R. L. (2000). Estrogenic actifity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol. Sci. 54, 154-167.
23. Martin, R. B., Chow, B. D., and Lucas, P. A. (1990). Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs. Calcif. Tissue Int. 46, 189-194.
24. Masuno, H., Iwanami, J., Kidani, T., Sakayama, K., and Honda, K. (2005). Bisphenol A accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the, phosphatidylinositol 3-kinase pathway. Toxicol. Sci. 84, 319-327.
25. Masuno, H., Okamoto, S., Iwanami, J., Honda, K., Shiosaka, T., Kidani, T., Sakayama, K., and Yamamoto, H. (2003). Effect of 4-nonylphenol on cell proliferation and adipocyte formation in cultures of fully differentiated 3T3-L1 cells. Toxicol. Sci. 75, 314-320.
26. Nimrod, A. C., and Benson, W. H. (1996). Environmental estrogenic effects of alkylphenol ethoxylates. Crit. Rev. Toxicol. 69, 335-364.
27. Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., and Walsh, K. (2003). Obesity, adiponectin and vascular inflammatory disease. Curr. Opin. Lipidol. 14, 561-566.
28. Reznikoff, C. A., Brankow, D. W., and Heidelberger, C. (1973). Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res. 33, 3231-3238.
29. Riggs, B. L., Khosla, S., and Melton, L. J. (1998). A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res. 13, 763-773.
30. Rozman, C., Feliu, E., Berga, L., Reverter, J. C., Climent, C., and Ferran, M. J. (1989). Age related variations of fat tissue fraction in normal bond marrow depend both or size and number of adipocytes: A stereological study. Exp. Hematol, 17, 34-37.
31. Rzonca, S. O., Suva, L. J., Gaddy, D., Montague, D. C., and Lecka-Czemic, B. (2004). Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology 145, 401-406.
32. Schoonjans, K., Peinado-Onsurbe, J., Lefebvre, A.-M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., and Auwerx, J. (1996). PPARα and PPARr activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase. EMBO J. 15, 5336-5348.
33. Shiraishi, H., Carter, D. S., and Hites, R. A. (1989). Identification and determination of tert-alkylphenols in carp from the Trenton Channel of the Detroit River, Michigan, USA. Biomed. Environ. Mass Spectrom. 18, 478-483.
34. Tontonoz, P., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994). mPPARr2: Tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8, 1224-1234.
35. White, R., Jobling, S., Hoare, S. A., Sumpter, J. P., and Parker, M. G. (1994). Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.
36. Wright, H. M., Clish, C. B., Mikami, T., Hauser, S., Yanagi, K., Hiramatsu, R., Serhan, C. N., and Spiegelman, B. M. (2000). A synthetic antagonist for the peroxisome proliferator-activated receptor r inhibits adipocyte differentiation. J. Biol. Chem. 275, 1873-1877.