Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 3, 2008, Pages 303-309

  Zhang, Ben Jian ^a,b   Xu, Dan ^a   Guo, Yu ^a   Ping, Jie ^a   Chen, Liao Bin ^b   Wang, Hui ^a  

^a WUHAN UNIVERSITY   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

smooth muscle actin; Anti oxidant; Berberine; Hepatic stellate cells; Liver fibrosis; Transforming growth factor 1

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; BERBERINE; CARBON TETRACHLORIDE; HYDROXYPROLINE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROLIFERATION; CHOLESTEROL DIET; CONTROL GROUP; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HISTOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER BIOPSY; LIVER FIBROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MYOFIBROBLAST; NECROSIS; NONHUMAN; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; STEATOSIS; WISTAR RAT;

ACTINS; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BERBERINE; CARBON TETRACHLORIDE; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; HEPATITIS, TOXIC; HYDROXYPROLINE; LIVER; LIVER CIRRHOSIS; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR;

EID: 39149118016     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04819.x     Document Type: Article

References (38)

1. Friedman SL. Liver fibrosis: From bench to bedside. J. Hepatol. 2003 38 : 38 53.
2. Maier KP. Drug therapy in chronic liver disease. Schweiz. Rundsch. Med. Prax. 2005 94 : 1907 12.
3. Gressner AM, Lotfi S, Gressner G, Haltner E, Kropf J. Synergism between hepatocytes and Kupffer cells in the activation of fat storing cells. J. Hepatol. 1993 19 : 117 32.
4. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA, Brenner DA. The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology 2001 34 : 89 100.
5. Gressner AM, Weiskirchen R, Breitkopf K, Dooley S. Roles of TGF-beta in hepatic fibrosis. Front. Biosci. 2002 7 : 793 807.
6. Dooley S, Streckert M, Delvoux B, Gressner AM. Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts. Biochem. Biophys. Res. Commun. 2001 283 : 554 62.
7. Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 2000 31 : 1094 106.
8. Zhao C, Chen W, Yang L, Chen L, Stimpson SA, Diehl AM. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem. Biophys. Res. Commun. 2006 350 : 385 91.
9. Bataller R, Brenner DA. Liver fibrosis. J. Clin. Invest. 2005 115 : 209 18.
10. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 2000 275 : 2247 50.
11. Lotersztajn S, Julien B, Teixeira-Clerc F, Grenard P, Mallat A. Hepatic fibrosis: Molecular mechanism and drug targets. Annu. Rev. Pharmacol. Toxicol. 2005 45 : 605 28.
12. Wu J, Danielsson A, Zern MA. Toxicity of hepatotoxins: New insights into mechanisms and therapy. Exp. Opin. Invest. Drugs 1999 8 : 585 607.
13. Parola M, Robino G, Dianzani MU. 4-Hydroxy-2,3-alkenals as molecular mediators of oxidative stress in the pathogenesis of liver fibrosis. Int. J. Mol. Med. 1999 4 : 425 32.
14. Greenwel P. Acetaldehyde-mediated collagen regulation in hepatic stellate cells. Alcohol. Clin. Exp. Res. 1999 23 : 930 3.
15. Pietrangelo A. Metals, oxidative stress, and hepatic fibrogenesis. Semin. Liver Dis. 1996 16 : 13 30.
16. Svegliati Baroni G, D'Ambrosio L, Ferretti G et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 1998 27 : 720 6.
17. Tsukamoto H, Rippe R, Niemela O, Lin M. Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis. J. Gastroenterol. Hepatol. 1995 10 : 50 3.
18. De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J. Biol. Chem. 1999 274 : 33 881 7.
19. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 2000 279 : L1005 28.
20. Gebhardt R. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med. 2002 68 : 289 96.
21. Cicero AF, Rovati LC, Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. Arzneimittelforschung 2007 57 : 26 30.
22. Yu HH, Kim KJ, Cha JD et al. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J. Med. Food 2005 8 : 454 61.
23. Choi BH, Ahn IS, Kim YH et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp. Mol. Med. 2006 38 : 599 605.
24. Tang LQ, Wei W, Chen LM, Liu S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J. Ethnopharmacol. 2006 108 : 109 15.
25. Peng PL, Hsieh YS, Wang CJ, Hsu JL, Chou FP. Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicol. Appl. Pharmacol. 2006 214 : 8 15.
26. Ko YJ, Lee JS, Park BC, Shin HM, Kim JA. Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells. Vasc. Pharmacol. 2007 47 : 189 96.
27. Hwang JM, Wang CJ, Chou FP et al. Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver. Arch. Toxicol. 2002 76 : 664 70.
28. Cho BJ, Im EK, Kwon JH et al. Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells. Mol. Cell. 2005 20 : 429 34.
29. Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis. Hepatology 1994 19 : 1262 71.
30. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J. Clin. Invest. 1995 96 : 2461 8.
31. Geesin JC, Hendricks LJ, Falkenstein PA, Gordon JS, Berg RA. Regulation of collagen synthesis by ascorbic acid: Characterization of the role of ascorbate-stimulated lipid peroxidation. Arch. Biochem. Biophys. 1991 290 : 127 32.
32. Poli G. Pathogenesis of liver fibrosis: Role of oxidative stress. Mol. Aspects Med. 2000 21 : 49 98.
33. Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. Hepatic stellate cell/myofibroblast subpopulations in fi brotic human and rat livers. J. Hepatol. 2002 36 : 200 9.
34. Ramm GA, Carr SC, Bridle KR et al. Morphology of liver repair following cholestatic liver injury: Resolution of ductal hyperplasia, matrix deposition and regression of myofi broblasts. Liver 2000 20 : 387 96.
35. Okazaki I, Watanabe T, Hozawa S, Arai M, Maruyama K. Molecular mechanism of the reversibility of hepatic fibrosis: With special reference to the role of matrix metalloproteinases. J. Gastroenterol. Hepatol. 2000 15 : 26 32.
36. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. The role of TGF beta1 in initiating hepatic stellate cell activation in vivo. J. Hepatol. 1999 30 : 77 87.
37. Wasser S, Ho JM, Ang HK, Tan CE. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. J. Hepatol. 1998 29 : 760 71.
38. Bissel DM, Friedman SL, Maher JJ, Roll FJ. Connective tissue biology and hepatic fibrosis: Report of a conference. Hepatology 1990 11 : 488 98.