Morphology of liver repair following cholestatic liver injury: Resolution of ductal hyperplasia, matrix deposition and regression of myofibroblasts

Liver

Volumn 20, Issue 5, 2000, Pages 387-396

  Ramm, Grant A ^a   Carr, Sandra C ^c   Bridle, Kim R ^a   Li, N ^d   Britton, Robert S ^d,e   Crawford, Darrell H G ^a,b   Vogler, Carol A ^e   Bacon, Bruce R ^d   Tracy Jr , Thomas F ^f  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c Division of Pediatric Surgery

^d Division of Gastroenterology and Hepatology

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BROWN UNIVERSITY   (United States)

Author keywords

Collagen; Cytokeratin 19; Hepatic fibrosis; Hepatic stellate cells; Smooth muscle actin

Indexed keywords

ALPHA ACTIN; COLLAGEN; CYTOKERATIN 19; MESSENGER RNA; MUSCLE PROTEIN; PROCOLLAGEN; RETICULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT DISEASE; CELL ACTIVITY; CELL DIFFERENTIATION; CHOLESTASIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DECOMPRESSION; EXTRACELLULAR MATRIX; EXTRAHEPATIC BILE DUCT OBSTRUCTION; FIBROBLAST; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER REGENERATION; MALE; MORPHOLOGY; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE; STELLATE CELL; TISSUE SECTION;

ACTINS; ALANINE TRANSAMINASE; ANIMALS; BILE DUCTS; BILIRUBIN; CHOLESTASIS, EXTRAHEPATIC; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; FIBROBLASTS; GAMMA-GLUTAMYLTRANSFERASE; HISTOCYTOCHEMISTRY; HYPERPLASIA; KERATINS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER REGENERATION; MALE; PROCOLLAGEN; RATS; RATS, SPRAGUE-DAWLEY; RETICULIN; RNA, MESSENGER;

EID: 0033810010     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0676.2000.020005387.x     Document Type: Article

References (38)

1. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
2. In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury
3. Transient expression of tenascin in experimentally induced cholestatic fibrosis in rat liver: An immunohistochemical study
4. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture
5. Phenotypic change in portal fibroblasts in biliary fibrosis
6. Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat
7. Cholestasis
8. Morphologic investigation of sinusoidal cells
9. Reversible biliary cirrhosis in rat after partial ligation of common bile duct
10. Recovery from biliary obstruction after spontaneous restoration of the obstructed common bile-duct
11. Portal hypertension after bile duct obstruction: Effect of bile diversion on portal pressure in the rat
12. Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus
13. Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat
14. Reversibility of secondary biliary fibrosis by biliodigestive anastomosis in the rat
15. The expression of regenerative growth factors in chronic liver injury and repair
16. Regeneration of liver after biliary cirrhosis
17. Regression of biliary cirrhosis following choledochal cyst drainage
18. Liver regeneration
19. A model of reversible obstructive jaundice in the rat
20. Chronic iron overload causes activation of rat lipocytes in vivo
21. Combination of non-isotopic in situ hybridisation with detection of enzyme activity, bromodeoxyuridine incorporation and immunohistochemical markers
22. Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat
23. Growth-related gene expression in early cholestatic liver injury
24. Cell proliferation and oncogene expression after bile duct ligation in the rat: Evidence of a specific growth effect on bile duct cells
25. Immunohistochemical demonstration of collagen types III and IV and myofibroblasts in the liver of patients with biliary atresia
26. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
27. Hepatic stellate cells
28. Tumor necrosis factor alpha (TNFα) and transforming growth factor β1 (TGFβ1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts
29. Transforming growth factors β1 and β2 are differentially expressed in fibrotic liver disease
30. Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice
31. Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
32. Growth factors as survival factors: Regulation of apoptosis
33. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
34. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair
35. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
36. Cellular sources of matrix proteins in experimentally induced cholestatic rat liver
37. Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis
38. Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis