메뉴 건너뛰기




Volumn 7, Issue 1, 2008, Pages 33-43

Epidermal growth factor receptor inhibitor-related skin toxicity: Mechanisms, treatment, and its potential role as a predictive marker

Author keywords

Cetuximab; Panitumumab; Rash; Targeted therapy; Tyrosine kinase inhibitors

Indexed keywords

ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BETAMETHASONE VALERATE; CETIRIZINE; CETUXIMAB; CISPLATIN; CLINDAMYCIN; DUODERM; EMOLLIENT AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUCLOXACILLIN; GEFITINIB; GEMCITABINE; HYDROXYZINE; IRINOTECAN; ISOTRETINOIN; LAPATINIB; LORATADINE; LYMECYCLINE; MINOCYCLINE; MONOCLONAL ANTIBODY; PANITUMUMAB; PREGABALIN; PROTEIN TYROSINE KINASE INHIBITOR; SILVER NITRATE; SUCRALFATE; TAZAROTENE; TETRACYCLINE; UNINDEXED DRUG;

EID: 39149117695     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2008.n.005     Document Type: Review
Times cited : (57)

References (97)
  • 1
    • 0026786652 scopus 로고
    • Expression of epidermal growth factor receptor and transforming growth factor alpha in human larynx carcinoma
    • Di Marco E, Albanese E, Benso S, et al. Expression of epidermal growth factor receptor and transforming growth factor alpha in human larynx carcinoma. Cancer Lett 1992; 65:189-99.
    • (1992) Cancer Lett , vol.65 , pp. 189-199
    • Di Marco, E.1    Albanese, E.2    Benso, S.3
  • 2
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995; 19:183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3
  • 3
    • 0029074587 scopus 로고
    • Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    • Miettinen PJ, Berger JE, Meneses J, et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995; 376:337-41.
    • (1995) Nature , vol.376 , pp. 337-341
    • Miettinen, P.J.1    Berger, J.E.2    Meneses, J.3
  • 4
    • 0033992633 scopus 로고    scopus 로고
    • Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors
    • Klapper LN, Kirschbaum MH, Sela M, et al. Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. Adv Cancer Res 2000; 77:25-79.
    • (2000) Adv Cancer Res , vol.77 , pp. 25-79
    • Klapper, L.N.1    Kirschbaum, M.H.2    Sela, M.3
  • 5
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
    • Alroy I, Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 1997; 410:83-6.
    • (1997) FEBS Lett , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 6
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103:211-25.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 7
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37(suppl 4):S3-8.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 9
    • 0034799139 scopus 로고    scopus 로고
    • A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
    • Ciardiello F, Tortora G. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res 2001; 7:2958-70.
    • (2001) Clin Cancer Res , vol.7 , pp. 2958-2970
    • Ciardiello, F.1    Tortora, G.2
  • 11
    • 0036433244 scopus 로고    scopus 로고
    • An update of new targets for cancer treatment: Receptor-mediated signals
    • Ciardiello F. An update of new targets for cancer treatment: receptor-mediated signals. Ann Oncol 2002; 13(suppl 4):29-38.
    • (2002) Ann Oncol , vol.13 , Issue.SUPPL. 4 , pp. 29-38
    • Ciardiello, F.1
  • 12
    • 0027415146 scopus 로고
    • The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
    • Mayer A, Takimoto M, Fritz E. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993; 71:2454-60.
    • (1993) Cancer , vol.71 , pp. 2454-2460
    • Mayer, A.1    Takimoto, M.2    Fritz, E.3
  • 13
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-45.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 14
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination-with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
    • Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination-with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004; 22:777-84.
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 15
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 2004; 22:785-94.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 16
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues PJ, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005; 353:123-32.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues, P.J.2    Ciuleanu, T.3
  • 17
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007; 25:1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 18
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21:2787-99.
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 19
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P, Matsumoto T, Inoue K, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 1999; 5:257-5.
    • (1999) Clin Cancer Res , vol.5 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 20
    • 2142714017 scopus 로고    scopus 로고
    • Monoclonal antibodies as therapeutic agents for cancer
    • Harris M. Monoclonal antibodies as therapeutic agents for cancer. Lancet Oncol 2004; 5:292-302.
    • (2004) Lancet Oncol , vol.5 , pp. 292-302
    • Harris, M.1
  • 21
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F, Bianco R, Damiano V. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 2000; 6:3739-47.
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 22
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz L, Meropol NJ, Loehrer PJ, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22:1201-8.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.1    Meropol, N.J.2    Loehrer, P.J.3
  • 23
    • 84898690826 scopus 로고    scopus 로고
    • Van Cutsem E, Nowacki M, Lang I, et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
    • Van Cutsem E, Nowacki M, Lang I, et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. J Clin Oncol 2007; 25(18 suppl):164s (Abstract 4000).
  • 24
    • 6344272498 scopus 로고    scopus 로고
    • ABX-EGF monotherapy in patients with metastatic colorectal cancer (mCRC): An update analysis
    • Abstract 3511
    • Hecht JR, Patnaik A, Malik I. ABX-EGF monotherapy in patients with metastatic colorectal cancer (mCRC): an update analysis. J Clin Oncol 2004; 22:248 (Abstract 3511).
    • (2004) J Clin Oncol , vol.22 , pp. 248
    • Hecht, J.R.1    Patnaik, A.2    Malik, I.3
  • 25
    • 0032719534 scopus 로고    scopus 로고
    • Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas
    • Akimoto T, Hunter NR, Buchmiller L, et al. Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clin Cancer Res 1999; 5:2884-90.
    • (1999) Clin Cancer Res , vol.5 , pp. 2884-2890
    • Akimoto, T.1    Hunter, N.R.2    Buchmiller, L.3
  • 26
    • 4644299213 scopus 로고    scopus 로고
    • The epidermal growth factor receptor is involved in accelerated repopulation in squamous cell carcinoma of the head and neck
    • Atasoy BM, Bentzen SM, Trott KR. The epidermal growth factor receptor is involved in accelerated repopulation in squamous cell carcinoma of the head and neck. Exp Strahlenther Klin Strahlenbiol 2004; 13:39-41.
    • (2004) Exp Strahlenther Klin Strahlenbiol , vol.13 , pp. 39-41
    • Atasoy, B.M.1    Bentzen, S.M.2    Trott, K.R.3
  • 27
    • 20444492764 scopus 로고    scopus 로고
    • Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors
    • Sartor CI. Mechanisms of disease: radiosensitization by epidermal growth factor receptor inhibitors. Nat Clin Pract Oncol 2004; 1:80-7.
    • (2004) Nat Clin Pract Oncol , vol.1 , pp. 80-87
    • Sartor, C.I.1
  • 28
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus Cetuximab for Squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt JL. Radiotherapy plus Cetuximab for Squamous-cell carcinoma of the head and neck. N Engl J Med 2006; 354:567-78.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.L.3
  • 29
    • 33751169352 scopus 로고    scopus 로고
    • Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer
    • Hofheinz RD, Horisberger K, Woernle C, et al. Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer. Int J Radiat Oncol Biol Phys 2006; 66:1384-90.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 1384-1390
    • Hofheinz, R.D.1    Horisberger, K.2    Woernle, C.3
  • 30
    • 34047179551 scopus 로고    scopus 로고
    • Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer
    • Machiels JP, Sempoux C, Scalliet P, et al. Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann Oncol 2007; 18:738-44.
    • (2007) Ann Oncol , vol.18 , pp. 738-744
    • Machiels, J.P.1    Sempoux, C.2    Scalliet, P.3
  • 31
    • 24044500971 scopus 로고    scopus 로고
    • Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
    • Segaert S, Van Cutsem E. Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Ann Oncol 2005; 16:1425-33.
    • (2005) Ann Oncol , vol.16 , pp. 1425-1433
    • Segaert, S.1    Van Cutsem, E.2
  • 33
    • 0035724536 scopus 로고    scopus 로고
    • Cutaneous side-effects in patients treated with the antiepidermal growth factor receptor antibody C225
    • Busam KJ, Capodieci P, Motzer R, et al. Cutaneous side-effects in patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol 2001; 144:1169-76.
    • (2001) Br J Dermatol , vol.144 , pp. 1169-1176
    • Busam, K.J.1    Capodieci, P.2    Motzer, R.3
  • 35
    • 0036788811 scopus 로고    scopus 로고
    • Paronychia induced by cetuximab, an antiepidermal growth factor receptor antibody
    • Boucher KW, Davidson K, Mirkhur B, et al. Paronychia induced by cetuximab, an antiepidermal growth factor receptor antibody. J Am Acad Dermatol 2002; 45:632-3.
    • (2002) J Am Acad Dermatol , vol.45 , pp. 632-633
    • Boucher, K.W.1    Davidson, K.2    Mirkhur, B.3
  • 36
    • 27144459674 scopus 로고    scopus 로고
    • Trichomegaly of the eyelashes following treatment with cetuximab
    • Bouche O, Brixi-Brenmasour H, Bertin A. Trichomegaly of the eyelashes following treatment with cetuximab. Ann Oncol 2005; 16:1711-2.
    • (2005) Ann Oncol , vol.16 , pp. 1711-1712
    • Bouche, O.1    Brixi-Brenmasour, H.2    Bertin, A.3
  • 37
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M, Siu LL, Nemunaitis J, et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001; 19: 3267-79.
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3
  • 38
    • 0036569870 scopus 로고    scopus 로고
    • ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
    • Ranson M, Hammond LA, Ferry D, et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J Clin Oncol 2002; 20:2240-50.
    • (2002) J Clin Oncol , vol.20 , pp. 2240-2250
    • Ranson, M.1    Hammond, L.A.2    Ferry, D.3
  • 39
    • 10744221013 scopus 로고    scopus 로고
    • Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody
    • Foon KA, Yang X, Weiner LM, et al. Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody. Int J Radiat Oncol Biol Phys 2004; 58:984-90.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 984-990
    • Foon, K.A.1    Yang, X.2    Weiner, L.M.3
  • 40
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • Baselga J, Pfister D, Cooper MR, et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000; 18:904-14.
    • (2000) J Clin Oncol , vol.18 , pp. 904-914
    • Baselga, J.1    Pfister, D.2    Cooper, M.R.3
  • 41
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • Baselga J, Rischin D, Ranson M, et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 2002; 20:4292-302.
    • (2002) J Clin Oncol , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3
  • 42
    • 4143050397 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer
    • Rowinsky EK, Schwartz GH, Jared A, et al. Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer. J Clin Oncol 2004; 22:3003-15.
    • (2004) J Clin Oncol , vol.22 , pp. 3003-3015
    • Rowinsky, E.K.1    Schwartz, G.H.2    Jared, A.3
  • 43
    • 0036051312 scopus 로고    scopus 로고
    • Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor
    • Van Doorn R, Kirtschig G, Scheffer E, et al. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor. Br J Dermatol 2002; 147:598-601.
    • (2002) Br J Dermatol , vol.147 , pp. 598-601
    • Van Doorn, R.1    Kirtschig, G.2    Scheffer, E.3
  • 44
    • 0025748048 scopus 로고
    • Acneiform eruption due to "megadose" vitamins B6 and B12
    • Sherertz EF. Acneiform eruption due to "megadose" vitamins B6 and B12. Cutis 1991; 48:119-20.
    • (1991) Cutis , vol.48 , pp. 119-120
    • Sherertz, E.F.1
  • 45
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial)
    • Fukuoka M, Yano S, Giaccone G. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial). J Clin Oncol 2003; 21:2237-46.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 46
    • 0000363733 scopus 로고    scopus 로고
    • Results of a phase I trial of the humanized anti epidermal growth factor receptor (EGFR) monoclonal antibody EMD 72000 in patients with EGFR expressing solid tumors
    • Abstract 378
    • Tewes M, Schleucher N, Dirsch O, et al. Results of a phase I trial of the humanized anti epidermal growth factor receptor (EGFR) monoclonal antibody EMD 72000 in patients with EGFR expressing solid tumors. Proc Am Soc Clin Oncol 2001; 20:95a (Abstract 378).
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Tewes, M.1    Schleucher, N.2    Dirsch, O.3
  • 47
    • 0035398021 scopus 로고    scopus 로고
    • Phase I study of antiepidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
    • Robert F, Ezekiel MP, Spencer SA, et al. Phase I study of antiepidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol 2001; 19:3234-43.
    • (2001) J Clin Oncol , vol.19 , pp. 3234-3243
    • Robert, F.1    Ezekiel, M.P.2    Spencer, S.A.3
  • 48
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003; 290:2149-58.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 49
    • 0001412078 scopus 로고    scopus 로고
    • Acne-like rash predicts response in patients treated with cetuximab (IMC-C225) plus irinotecan (CPT-11) in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • 3766s
    • Saltz L, Rubin MS, Hochster H, et al. Acne-like rash predicts response in patients treated with cetuximab (IMC-C225) plus irinotecan (CPT-11) in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Clin Cancer Res 2001; 7:3766s.
    • (2001) Clin Cancer Res , vol.7
    • Saltz, L.1    Rubin, M.S.2    Hochster, H.3
  • 50
    • 0141708467 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic (PK) study of oral GW572016, a potent reversible dual inhibitor of both erbB1 and erbB2 tyrosine kinase (TK) , administered in combination with capecitabine
    • Abstract 225
    • De Bono JS, Schwartz G, Monroe P, et al. Phase I and pharmacokinetic (PK) study of oral GW572016, a potent reversible dual inhibitor of both erbB1 and erbB2 tyrosine kinase (TK) , administered in combination with capecitabine. Proc Am Soc Clin Oncol 2003; 22:56 (Abstract 225).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 56
    • De Bono, J.S.1    Schwartz, G.2    Monroe, P.3
  • 51
    • 0036142522 scopus 로고    scopus 로고
    • Follicular toxic effects of chimeric anti-epidermal growth factor receptor antibody cetuximab used to treat human solid tumors
    • Kimyai-Asadi A, Jih MH. Follicular toxic effects of chimeric anti-epidermal growth factor receptor antibody cetuximab used to treat human solid tumors. Arch Dermatol 2002; 138:129-31.
    • (2002) Arch Dermatol , vol.138 , pp. 129-131
    • Kimyai-Asadi, A.1    Jih, M.H.2
  • 52
    • 0038080138 scopus 로고    scopus 로고
    • Dermatological side effects associated with gefitinib therapy: Clinical experience and management
    • Herbst RS, LoRusso PM, Purdom M, et al. Dermatological side effects associated with gefitinib therapy: clinical experience and management. Clin Lung Cancer 2003; 4:366-9.
    • (2003) Clin Lung Cancer , vol.4 , pp. 366-369
    • Herbst, R.S.1    LoRusso, P.M.2    Purdom, M.3
  • 53
    • 26944467607 scopus 로고    scopus 로고
    • The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies
    • Segaert S, Tabernero J, Chosidow O, et al. The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies. J Dtsch Dermatol Ges 2005; 3:599-606.
    • (2005) J Dtsch Dermatol Ges , vol.3 , pp. 599-606
    • Segaert, S.1    Tabernero, J.2    Chosidow, O.3
  • 54
    • 16644369733 scopus 로고    scopus 로고
    • Practical management of patients with non-small-cell lung cancer treated with gefitinib
    • Shah NT, Kris MG, Pao W, et al. Practical management of patients with non-small-cell lung cancer treated with gefitinib. J Clin Oncol 2005; 23:165-74.
    • (2005) J Clin Oncol , vol.23 , pp. 165-174
    • Shah, N.T.1    Kris, M.G.2    Pao, W.3
  • 55
    • 11944254029 scopus 로고    scopus 로고
    • Complications of therapy in cancer patients: Case 1. Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancer
    • Chang CG, Yang TY, Chen KC. Complications of therapy in cancer patients: case 1. Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 2004; 22:4646-8.
    • (2004) J Clin Oncol , vol.22 , pp. 4646-4648
    • Chang, C.G.1    Yang, T.Y.2    Chen, K.C.3
  • 56
    • 33746920516 scopus 로고    scopus 로고
    • Description and management of cutaneous side effects during cetuximab or erlotinib treatments: A prospective study of 30 patients
    • Roé E, García Muret MP, Marcuello E, et al Description and management of cutaneous side effects during cetuximab or erlotinib treatments: a prospective study of 30 patients. J Am Acad Dermatol 2006; 55:429-37.
    • (2006) J Am Acad Dermatol , vol.55 , pp. 429-437
    • Roé, E.1    García Muret, M.P.2    Marcuello, E.3
  • 57
    • 0036245242 scopus 로고    scopus 로고
    • Getting under the skin of epidermal morphogenesis
    • Fuchs E, Raghavan S. Getting under the skin of epidermal morphogenesis. Nat Rev Genet 2002; 3:199-209.
    • (2002) Nat Rev Genet , vol.3 , pp. 199-209
    • Fuchs, E.1    Raghavan, S.2
  • 58
    • 0025280342 scopus 로고
    • Immunolocalization of epidermal growth factor receptors in normal developing human skin
    • Nanney LB, Stoscheck CM, King LE. Immunolocalization of epidermal growth factor receptors in normal developing human skin. J Invest Dermatol 1990; 94:742-8.
    • (1990) J Invest Dermatol , vol.94 , pp. 742-748
    • Nanney, L.B.1    Stoscheck, C.M.2    King, L.E.3
  • 59
    • 0031436799 scopus 로고    scopus 로고
    • EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation
    • Peud D, Hamacher L, Pittelkow. MR EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation. J Invest Dermatol 1997; 109:751-6.
    • (1997) J Invest Dermatol , vol.109 , pp. 751-756
    • Peud, D.1    Hamacher, L.2    Pittelkow, M.R.3
  • 60
    • 0036139727 scopus 로고    scopus 로고
    • Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
    • Albanell J, Rojo F, Averbuch S, et al. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. J Clin Oncol 2001; 20:110-24.
    • (2001) J Clin Oncol , vol.20 , pp. 110-124
    • Albanell, J.1    Rojo, F.2    Averbuch, S.3
  • 61
    • 12444259660 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients
    • Malik SN, Siu LL, Rowinsky EK, et al. Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients. Clin Cancer Res 2003; 9:2478-86.
    • (2003) Clin Cancer Res , vol.9 , pp. 2478-2486
    • Malik, S.N.1    Siu, L.L.2    Rowinsky, E.K.3
  • 62
    • 18044364483 scopus 로고    scopus 로고
    • Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment
    • Woodworth CD, Michael E, Marker, et al. Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment. Mol Cancer Ther 2005; 4:650-8.
    • (2005) Mol Cancer Ther , vol.4 , pp. 650-658
    • Woodworth, C.D.1    Michael, E.2    Marker3
  • 63
    • 0031045848 scopus 로고    scopus 로고
    • EGF-R dependent regulation of keratinocyte survival
    • Rodeck U, Jost M, Kari C, et al. EGF-R dependent regulation of keratinocyte survival. J Cell Sci 1997; 110(pt 2):113-21.
    • (1997) J Cell Sci , vol.110 , Issue.PART 2 , pp. 113-121
    • Rodeck, U.1    Jost, M.2    Kari, C.3
  • 64
    • 0038306878 scopus 로고    scopus 로고
    • Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation
    • Mascia M, Mariani V, Girolami G, et al. Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation. Am J Pathol 2003; 163:303-12.
    • (2003) Am J Pathol , vol.163 , pp. 303-312
    • Mascia, M.1    Mariani, V.2    Girolami, G.3
  • 65
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture ME. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer 2006; 6:803-12.
    • (2006) Nat Rev Cancer , vol.6 , pp. 803-812
    • Lacouture, M.E.1
  • 66
    • 0028784049 scopus 로고
    • Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure
    • Murillas R, Larcher F, Conti CJ, et al. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J 1995; 14:5216-23.
    • (1995) EMBO J , vol.14 , pp. 5216-5223
    • Murillas, R.1    Larcher, F.2    Conti, C.J.3
  • 67
    • 33745909120 scopus 로고    scopus 로고
    • Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer
    • Gibson TB, Ranganathan A, Grothey A. Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer. Clin Colorectal Cancer 2006; 6:29-31.
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 29-31
    • Gibson, T.B.1    Ranganathan, A.2    Grothey, A.3
  • 68
    • 0026801151 scopus 로고
    • Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing
    • Heck DE, Laskin DL, Gardner CR, et al. Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing. J Biol Chem 1992; 267:21277-80.
    • (1992) J Biol Chem , vol.267 , pp. 21277-21280
    • Heck, D.E.1    Laskin, D.L.2    Gardner, C.R.3
  • 69
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20:719-26.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 70
    • 27644571558 scopus 로고    scopus 로고
    • Antibody-based therapies for colorectal cancer
    • Chung KY, Saltz LB. Antibody-based therapies for colorectal cancer. Oncologist 2005; 10:701-9.
    • (2005) Oncologist , vol.10 , pp. 701-709
    • Chung, K.Y.1    Saltz, L.B.2
  • 71
    • 0024429864 scopus 로고
    • Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors
    • Defize LH, Boonstra J, Meisenhelder J, et al. Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. J Cell Biol 1989; 109:2495-507.
    • (1989) J Cell Biol , vol.109 , pp. 2495-2507
    • Defize, L.H.1    Boonstra, J.2    Meisenhelder, J.3
  • 72
    • 34248344725 scopus 로고    scopus 로고
    • Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib
    • Clark GM, Zborowski DM, Culbertson JL, et al. Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib. J Thorac Oncol 2006; 1:837-46.
    • (2006) J Thorac Oncol , vol.1 , pp. 837-846
    • Clark, G.M.1    Zborowski, D.M.2    Culbertson, J.L.3
  • 73
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab pluschemotherapy
    • Di Fiore F, Blanchard F, Charbonnier F, et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab pluschemotherapy. Br J Cancer 2007; 96:1166-9.
    • (2007) Br J Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3
  • 74
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66:3992-5.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 75
    • 39349083477 scopus 로고    scopus 로고
    • EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer
    • 18 suppl):168s Abstract 4021
    • Finocchiaro G, Cappuzzo F, Jänne PA, et al. EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer. J Clin Oncol 2007; 25(18 suppl):168s (Abstract 4021).
    • (2007) J Clin Oncol , pp. 25
    • Finocchiaro, G.1    Cappuzzo, F.2    Jänne, P.A.3
  • 76
    • 84898694101 scopus 로고    scopus 로고
    • Wild-type K-RAS is required for Panitumumab efficacy in patients with mCRC: Results from a randomized, controlled trial
    • Presented at: September 23-27, Barcelona, Spain. Abstract 7
    • Amado RG, Wolf M, Freeman D, et al. Wild-type K-RAS is required for Panitumumab efficacy in patients with mCRC: results from a randomized, controlled trial. Presented at: the 14th Biannual European Cancer Conference; September 23-27, 2007; Barcelona, Spain. Abstract 7.
    • (2007) the 14th Biannual European Cancer Conference
    • Amado, R.G.1    Wolf, M.2    Freeman, D.3
  • 77
    • 25144491785 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: An immunohistochemical and chromogenic in situ hybridization study
    • Shia J, Klimstra DS, Li AR, et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Mod Pathol 2005; 18:1350-6.
    • (2005) Mod Pathol , vol.18 , pp. 1350-1356
    • Shia, J.1    Klimstra, D.S.2    Li, A.R.3
  • 78
    • 28844492704 scopus 로고    scopus 로고
    • Demonstration of EGFR gene copy loss in colorectal carcinomas by fluorescence in situ hybridization (FISH): A surrogate marker for sensitivity to specific anti-EGFR therapy?
    • Sauer T, Guren MG, Noren T, et al. Demonstration of EGFR gene copy loss in colorectal carcinomas by fluorescence in situ hybridization (FISH): a surrogate marker for sensitivity to specific anti-EGFR therapy? Histopathology 2005; 47:560-4.
    • (2005) Histopathology , vol.47 , pp. 560-564
    • Sauer, T.1    Guren, M.G.2    Noren, T.3
  • 79
    • 19944422060 scopus 로고    scopus 로고
    • Somatic mutations of EGFR in colorectal cancers and glioblastomas
    • Barber TD, Vogelstein B, Kinzler KV, et al. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N Engl J Med 2004; 351:2883.
    • (2004) N Engl J Med , vol.351 , pp. 2883
    • Barber, T.D.1    Vogelstein, B.2    Kinzler, K.V.3
  • 80
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial
    • Xiong HQ, Rosenberg A, Lo Buglio A, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol 2004; 22:2610-6.
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lo Buglio, A.3
  • 81
    • 0343569824 scopus 로고    scopus 로고
    • Modulation of EGFR gene transcription by a polymorphic repetitive sequence - a link between genetics and epigenetics
    • Gebhardt F, Burger H, Brandt B, et al. Modulation of EGFR gene transcription by a polymorphic repetitive sequence - a link between genetics and epigenetics. Int J Biol Markers 2000; 15:105-10.
    • (2000) Int J Biol Markers , vol.15 , pp. 105-110
    • Gebhardt, F.1    Burger, H.2    Brandt, B.3
  • 82
    • 33846979362 scopus 로고    scopus 로고
    • EGFR dinucleotide repeat polymorphism as a prognostic indicator in non-small cell lung cancer
    • Dubey S, Stephenson P, Levy DE, et al. EGFR dinucleotide repeat polymorphism as a prognostic indicator in non-small cell lung cancer. J Thorac Oncol 2006; 1:406-12.
    • (2006) J Thorac Oncol , vol.1 , pp. 406-412
    • Dubey, S.1    Stephenson, P.2    Levy, D.E.3
  • 83
    • 20044386667 scopus 로고    scopus 로고
    • Genotypic bases of EGFR inhibitors pharmacological actions
    • 14 suppl):196 Abstract 3005
    • Perea S, Oppenheimer D, Amador M, et al. Genotypic bases of EGFR inhibitors pharmacological actions. J Clin Oncol 2004; 22(14 suppl):196 (Abstract 3005).
    • (2004) J Clin Oncol , pp. 22
    • Perea, S.1    Oppenheimer, D.2    Amador, M.3
  • 84
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz HJ, Van Cutsem E, Khambata-Ford S, et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 2006; 24:4914-21.
    • (2006) J Clin Oncol , vol.24 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3
  • 85
    • 24944490558 scopus 로고    scopus 로고
    • Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck
    • Herbst RS, Arquette M, Shin DM, et al. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J Clin Oncol 2005; 23:5578-87.
    • (2005) J Clin Oncol , vol.23 , pp. 5578-5587
    • Herbst, R.S.1    Arquette, M.2    Shin, D.M.3
  • 86
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM, et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003; 21:1980-7.
    • (2003) J Clin Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3
  • 87
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
    • Abstract 204
    • Saltz L, Kies M, Abbruzzese JL, et al. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc Am Soc Clin Oncol 2003; 22:51 (Abstract 204).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 51
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3
  • 88
    • 20044370274 scopus 로고    scopus 로고
    • Skin rash and good performance status predict improved survival with gefitinib in patients with advanced non-small-cell lung cancer
    • Mohamed MK, Ramalingam S, Lin Y, et al. Skin rash and good performance status predict improved survival with gefitinib in patients with advanced non-small-cell lung cancer. Ann Oncol 2005; 16:780-5.
    • (2005) Ann Oncol , vol.16 , pp. 780-785
    • Mohamed, M.K.1    Ramalingam, S.2    Lin, Y.3
  • 89
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining?
    • Perez-Soler R, Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining? J Clin Oncol 2005; 23:5235-46.
    • (2005) J Clin Oncol , vol.23 , pp. 5235-5246
    • Perez-Soler, R.1    Saltz, L.2
  • 90
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25:1658-64.
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 91
    • 85031434626 scopus 로고    scopus 로고
    • Tejpar S, Peeters M, Humblet Y, et al. Cetuximab dose-escalation study in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST). Pharmacokinetic and efficacy data of a randomized study. J Clin Oncol 2007; 25(18 suppl):172s (Abstract 4037).
    • Tejpar S, Peeters M, Humblet Y, et al. Cetuximab dose-escalation study in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST). Pharmacokinetic and efficacy data of a randomized study. J Clin Oncol 2007; 25(18 suppl):172s (Abstract 4037).
  • 93
    • 84898690914 scopus 로고    scopus 로고
    • Prophylaxis with systemic minocycline and topical tazarotene (a retinoid) for the cetuximab associated acne-like eruption
    • Presented at: February 2-6, Washington, DC. Abstract P508
    • Agero AL, Scope A, Myskowski P, et al. Prophylaxis with systemic minocycline and topical tazarotene (a retinoid) for the cetuximab associated acne-like eruption. Presented at: the 2007 American Academy of Dermatology Annual Meeting; February 2-6, 2007; Washington, DC. Abstract P508.
    • (2007) the 2007 American Academy of Dermatology Annual Meeting
    • Agero, A.L.1    Scope, A.2    Myskowski, P.3
  • 94
    • 34147148650 scopus 로고    scopus 로고
    • Anti-inflammatory activity of tetracyclines
    • Webster G, Del Rosso JQ. Anti-inflammatory activity of tetracyclines. Dermatol Clin 2007; 25:133-5.
    • (2007) Dermatol Clin , vol.25 , pp. 133-135
    • Webster, G.1    Del Rosso, J.Q.2
  • 95
    • 85031448205 scopus 로고    scopus 로고
    • Jatoi A, Rowland K, Sloan JA, et al. Does tetracycline prevent/palliate epidermal growth factor receptor (EGFR) inhibitor-induced rash? a phase III trial from the North Central Cancer Treatment Group (N03CB). J Clin Oncol 2007; 25(18 suppl):494s (Abstract LBA9006).
    • Jatoi A, Rowland K, Sloan JA, et al. Does tetracycline prevent/palliate epidermal growth factor receptor (EGFR) inhibitor-induced rash? a phase III trial from the North Central Cancer Treatment Group (N03CB). J Clin Oncol 2007; 25(18 suppl):494s (Abstract LBA9006).
  • 96
    • 33750502032 scopus 로고    scopus 로고
    • Efficacy of pregabalin in the management of cetuximab-related itch
    • Porzio G, Aielli F, Verna L, et al Efficacy of pregabalin in the management of cetuximab-related itch. J Pain Symptom Manage 2006; 32:397-8.
    • (2006) J Pain Symptom Manage , vol.32 , pp. 397-398
    • Porzio, G.1    Aielli, F.2    Verna, L.3
  • 97
    • 0035158108 scopus 로고    scopus 로고
    • Systemic retinoid therapy
    • Di Giovanna. Systemic retinoid therapy. Dermatol Clin 2001; 19:161-7.
    • (2001) Dermatol Clin , vol.19 , pp. 161-167
    • Giovanna, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.