Enhanced expression of transforming growth factor-β1 in inflammatory cells, α-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice

Acta Tropica

Volumn 105, Issue 3, 2008, Pages 260-268

  Wu, Ming Shun ^a   Liao, Chien Wei ^b   Du, Wen Yun ^c   Kao, Ting Chang ^b   Su, Kua Eyre ^d   Lin, Yun Ho ^b   Chang, Chun Chao ^e   Fan, Chia Kwung ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e Division of Gastroenterology   (Taiwan)

Author keywords

Smooth muscle actins; Collagen; Granulomatous hepatitis; Immunohistochemistry; Mice; Stellate cells; Toxocara canis; Transforming growth factor 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; TRANSFORMING GROWTH FACTOR BETA1;

ACCUMULATION; COLLAGEN; CYTOLOGY; GENE EXPRESSION; HEPATITIS; LARVA; MUSCLE; NEMATODE; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; GRANULOMATOUS HEPATITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LEUKOCYTE; LIVER FIBROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; STELLATE CELL; TH2 CELL; TOXOCARA CANIS; TOXOCARIASIS; UPREGULATION; WOUND HEALING;

ACTINS; ANIMALS; BILE DUCTS; COLLAGEN; DOGS; FEMALE; HEPATITIS, ANIMAL; HEPATOCYTES; IMMUNOCHEMISTRY; LARVA; LIVER; MICE; MICE, INBRED ICR; MUSCLE, SMOOTH; TOXOCARA CANIS; TOXOCARIASIS; TRANSFORMING GROWTH FACTOR BETA1;

MUS; TOXOCARA CANIS;

EID: 39149100910     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2007.11.005     Document Type: Article

References (40)

1. Akao N., Kondo K., Sakai H., and Yoshimura H. An immunopathological study of the liver of the mice infected with Toxocara canis. Jpn. J. Parasitol. 35 (1986) 135-140
2. Baldisserotto M., Conchin C.F.M., Soares M.G.M., Araujo M.A., and Kramer B. Ultrasound findings in children with toxocariasis: report on 18 cases. Pediatr. Radiol. 29 (1999) 316-319
3. Bhatia V., and Sarin S.K. Hepatic visceral larva migrans: evolution of the lesion, diagnosis, and role of high-dose albendazole therapy. Am. J. Gastroenterol. 89 (1994) 624-627
4. Blobe G.C., Schiemann W.P., and Lodish H.F. Role of transforming growth factor beta in human disease. New Eng. J. Med. 342 (2000) 1350-1358
5. Boros D.L., and Whitfield J.R. Enhanced Th1 and dampened Th2 responses synergize to inhibit acute granulomatous and fibrotic responses in murine schistosomiasis mansoni. Infect. Immun. 67 (1999) 1187-1193
6. De Minicis S., Seki E., Uchinami H., Kluwe J., Zhang Y., Brenner D.A., and Schwabe R.F. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132 (2007) 1937-1946
7. Fan C.K., Lin Y.H., Du W.Y., and Su K.E. Infectivity and pathogenicity of 14-month-cultured embryonated eggs of Toxocara canis in mice. Vet. Parasitol. 113 (2003) 145-155
8. Fan C.K., Hung C.C., Lin Y.H., Li M.S., and Su K.E. Enhanced expression of transforming growth factor-beta 1 in inflammatory cells and secretory granules in Paneth cells in the small intestine of mice infected with Toxocara canis. Parasitol. Res. 94 (2004) 397-404
9. Farah I.O., Mola P.W., Kariuki T.M., Nyindo M., Blanton R.E., and King C.L. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons. Role of TGF-beta and IL-4. J. Immunol. 164 (2000) 5337-5343
10. Fitzpatrick D.R., and Bielefeldt-Ohmann H. Transforming growth factor β in infectious disease: always there for the host and the pathogen. Trends Microbiol. 7 (1999) 232-236
11. Freitas T.C., Jung E., and Pearce E.J. TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni. PLoS Pathog. 3 (2007) e52
12. Friedman S.L., Yamasaki G., and Wong L. Modulation of transforming growth factor-β 1 receptors of rat lipocytes during the hepatic wound healing response. J. Biol. Chem. 269 (1994) 10551-10558
13. Garcia-Trevijano E.R., Iraburu M.J., Fontana L., Dominguez-Rosales J.A., Auster A., Covarrubias-Pinedo A., and Rojkind M. Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. Hepatology 29 (1999) 960-970
14. Gomez-Escobar N., Lewis E., and Maizels R.M. A novel member of the transforming growth factor β (TGF-β) superfamily from the filarial nematodes Brugia malayi and B. pahangi. Exp. Parasitol. 88 (1998) 200-209
15. Hartleb M., and Januszewski K. Severe hepatic involvement in visceral larva migrans. Eur. J. Gastroenterol. Hepatol. 13 (2001) 1245-1249
16. Hautekeete M.L., and Geerts A. The hepatic stellate (Ito) cell: its role in human liver disease. Virch. Arch. 430 (1997) 195-207
17. Hellerbrand C., Stefanovic B., Giordano F., Burchardt E.R., and Brenner D.A. The role of TGF β1 in initiating hepatic stellate cell activation in vivo. J. Hepatol. 30 (1999) 77-87
18. Hernandez H.J., Rutitzky L.I., Lebens M., Holmgren J., and Stadecker M.J. Diminished immunopathology in Schistosoma mansoni infection following intranasal administration of cholera toxin B-immunodominant peptide conjugate correlates with enhanced transforming growth factor-β production by CD 4 T cells. Parasite Immunol. 24 (2002) 423-427
19. Hirata M., Hirata K., Hara T., Kawabuchi M., and Fukuma T. Expression of TGF-β-like molecules in the life cycle of Schistosoma japonicum. Parasitol. Res. 95 (2005) 367-373
20. Hui A.Y., Dannenberg A.J., Sung J.J., Subbaramaiah K., Du B., Olinga P., and Friedman S.L. Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells. J. Hepatol. 41 (2004) 251-258
21. Ishibashi H., Shimamura R., Hirata Y., Kudo J., and Onizuka H. Hepatic granuloma in toxocaral infection: role of ultrasonography in hypereosinophilia. J. Clin. Ultrasound. 20 (1992) 204-210
22. Kaplan K.J., Goodman Z.D., and Ishak K.G. Eosinophilic granuloma of the liver: a characteristic lesion with relationship to visceral larva migrans. Am. J. Surg. Pathol. 25 (2001) 1316-1321
23. Kaushik S.P., Hurwitz M., McDonald C., and Pavli P. Toxocara canis infection and granulomatous hepatitis. Am. J. Gastroenterol. 92 (1997) 1223-1225
24. Kayes S.G. Human toxocariasis and the visceral larva migrans syndrome: correlative immunopathology. Chem. Immunol. 66 (1997) 99-124
25. Kerr-Muir M.G. Toxocara canis and human health. Br. Med. J. 309 (1994) 5-6
26. Lewindon P.J., Pereira T.N., Hoskins A.C., Bridle K.R., Williamson R.M., Shepherd R.W., and Ramm G.A. The role of hepatic stellate cells and transforming growth factor-β1 in cystic fibrosis liver disease. Am. J. Pathol. 160 (2002) 1705-1715
27. Lopez M.L., Martin G., Chamorro M.C., and Mario A.J. Toxocariasis in children from a subtropical region. Medicina 65 (2005) 226-230
28. Lopez E., del Pozo V., Miguel T., Sastre B., Seoane C., Civantos E., Llanes E., Baeza M.L., Palomino P., Cárdaba B., Gallardo S., Manzarbeitia F., Zubeldia J.M., and Lahoz C. Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model. J. Immunol. 176 (2006) 1943-1950
29. Maher J.J. Interactions between hepatic stellate cells and the immune system. Semin. Liver Dis. 21 (2001) 417-426
30. Massague L. How cells read TGF-beta signals. Nat. Rev. Mol. Cell. Biol. 1 (2000) 169-178
31. Moreira-Silva S.F., and Pereira F.E. Intestinal nematodes, Toxocara infection, and pyogenic liver abscess in children: a possible association. J. Trop. Pediatr. 46 (2000) 167-172
32. Musso C., Castelo J.S., Tsanaclis A.M.C., and Pereira F.E. Prevalence of Toxocara-induced liver granulomas, detected by immunohistochemistry, in a series of autopsies at a Children's Reference Hospital in Vitoria, ES, Brazil. Virch. Arch. 450 (2007) 411-417
33. Myung S.J., Yoon J.H., Gwak G.Y., Kim W., Yang J.I., Lee S.H., Jang J.J., and Lee H.S. Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation. Biochem. Biophys. Res. Commun. 353 (2007) 1091-1096
34. Omer F.M., Kurtzhals J.A.L., and Riley E.M. Maintaining the immunological balance in parasitic infections: a role for TGF-β. Parasitol. Today 16 (2000) 18-23
35. Parsons J.C., Bowman D.D., and Grieve R.B. Tissue localization of excretory-secretory antigens of larval Toxocara canis in acute and chronic murine toxocariasis. Am. J. Trop. Med. Hyg. 35 (1986) 974-981
36. Piekarska A., Piekarski J., Szymczak W., and Kubiak R. Expression of Ki-67, transforming growth factor beta1, and B-cell lymphoma-leukemia-2 in liver tissue of patients with chronic liver diseases. J. Gastroenterol. Hepatol. 21 (2006) 700-710
37. Ponder D., Marshall G.S., Rabalais G.P., and Wood B.P. Radiological case of the month. Visceral larva migrans. Am. J. Dis. Child. 145 (1991) 699-700
38. Smith H.V. Immune evasion and immunopathology in Toxocara canis infection. In: Kennedy M.W. (Ed). Parasitic nematodes: antigens, membranes and genes (1991), Taylor & Francis, London 116-139
39. Wahl S.M., Frazier-Jessen M., Jin W.W., Kopp J.B., Sher A., and Cheever A.W. Cytokine regulation of Schistosome-induced granuloma and fibrosis. Kidney Int. 51 (1997) 1370-1375
40. Zyngier F.R. Histopathology of experimental toxocariasis in mice. Ann. Trop. Med. Parasitol. 68 (1974) 225-228