Leptomycin B, a metabolite of Streptomyces, inhibits the expression of inducible nitric oxide synthase in BV2 microglial cells

International Journal of Oncology

Volumn 29, Issue 6, 2006, Pages 1509-1515

  Jang, Byeong Churl ^a   Sung, S U Haeng ^a   Park, Jong G U ^a   Park, Jong Wook ^a   Suh, Min H O ^a   Choi, I N Hak ^b   Yoshida, Minoru ^c   Yoo, Sun Kyun ^d   Suh, Seong Il ^a  

^a Keimyung University School of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

^c RIKEN   (Japan)

^d Joongbu University   (South Korea)

Author keywords

BV2 cells; iNOS; Leptomycin B; LPS; MRNA stability and nuclear export; Transcription

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LEPTOMYCIN B; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NOS2 PROTEIN, MOUSE; UNSATURATED FATTY ACID;

ACTIVE TRANSPORT; ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MICROGLIA; MOUSE; STREPTOMYCES;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INDUCTION; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; STREPTOMYCES; TRANSCRIPTION, GENETIC;

EID: 39049193796     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.29.6.1509     Document Type: Article

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