Preferentially enhanced gene expression from a synthetic human telomerase reverse transcriptase promoter in human cancer cells

Oncology Reports

Volumn 16, Issue 5, 2006, Pages 975-979

  Kim, Sung Jin ^a   Lee, Han Saem ^a   Shin, June Ho ^b   Kim, Chul Geun ^b   Jeong, Sunjoo ^c   Park, Keerang ^d   Choe, Han ^a   Lee, Heuiran ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Dankook University   (South Korea)

^d Juseong College   (South Korea)

Author keywords

c Myc; Cancer gene therapy; Gene regulatory element; hTERT promoter; Sp1; TPL sequence

Indexed keywords

DNA BINDING PROTEIN; MYCBP PROTEIN, HUMAN; TELOMERASE; TERT PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1;

ARTICLE; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; HELA CELL; HUMAN; HUMAN ADENOVIRUS; METHODOLOGY; NEOPLASM; PROMOTER REGION; TUMOR CELL LINE;

ADENOVIRUSES, HUMAN; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HELA CELLS; HUMANS; NEOPLASMS; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR; TELOMERASE; TRANSCRIPTION FACTORS;

EID: 39049192223     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.16.5.975     Document Type: Article

References (37)

1. Vile RG and Rus NR: Cancer gene therapy: hard lessons and new courses. Gene Ther 7: 2-8, 2000.
2. Paillard F: Cancer gene therapy annual conference 1997: trends and news. Hum Gene Ther 9: 283-286, 1998.
3. Marchisone C, Pfeffer U, Del Grosso F, Noonan DM, Santi L and Albini A: Progress towards gene therapy for cancer. J Exp Clin Cancer Res 19: 261-270, 2000.
4. Harrington KJ, Linardakis E and Vile RG: Transcriptional control: an essential component of cancer gene therapy strategies? Adv Drug Deliv Rev 44: 167-184, 2000.
5. Choo R, De Boer G, Klotz L, et al: PSA doubling time of prostate carcinoma managed with watchful observation alone. Int J Radiat Oncol Biol Phys 50: 615-620, 2001. (Pubitemid 32519594)
6. Rodriguez R, Schuur ER, Lim HY, Henderson GA, Simons JW and Henderson DR: Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostatespecific antigen-positive prostate cancer cells. Cancer Res 57: 2559-2563, 1997. (Pubitemid 27283756)
7. Osaki T, Tanio Y, Tachibana I, et al: Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene. Cancer Res 54: 5258-5261, 1994. (Pubitemid 24336009)
8. Kijima T, Osaki T, Nishino K, et al: Application of the Cre recombinase/loxP system further enhances antitumor effects in cell type-specific gene therapy against carcinoembryonic antigen-producing cancer. Cancer Res 59: 4906-4911, 1999. (Pubitemid 29472895)
9. Kurihara T, Brough DE, Kovesdi I and Kufe DW: Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen. J Clin Invest 106: 763-771, 2000.
10. Putzer BM, Rumpf H, Rega S, Brockmann D and Esche H: E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter. J Virol 71: 9538-9548, 1997. (Pubitemid 27492400)
11. Kim NW, Piatyszek MA, Prowse KR, et al: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
12. Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 33: 787-791, 1997.
13. Kyo S, Takakura M and Inoue M: Telomerase activity in cancer as a diagnostic and therapeutic target. Histol Histopathol 15: 813-824, 2000. (Pubitemid 30488564)
14. Koga S, Hirohata S, Kondo Y, et al : A novel telomerasespecific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter. Hum Gene Ther 11: 1397-1406, 2000. (Pubitemid 30451020)
15. Gu J, Kagawa S, Takakura M, et al : Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res 60: 5359-5364, 2000.
16. Komata T, Koga S, Hirohata S, et al : A novel treatment of human malignant gliomas in vitro and in vivo : FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter. Int J Oncol 19: 1015-1020, 2001.
17. Kanaya T, Kyo S, Hamada K, et al: Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin Cancer Res 6: 1239-1247, 2000. (Pubitemid 30226203)
18. Wirth T, Zender L, Schulte B, et al : A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer. Cancer Res 63: 3181-3188, 2003. (Pubitemid 36735870)
19. Song JS: Adenovirus-mediated suicide SCLC gene therapy using the increased activity of the hTERT promoter by the MMRE and SV40 enhancer. Biosci Biotechnol Biochem 69: 56-62, 2005.
20. Abdul-Ghani R, Ohana P, Matouk I, et al : Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells. Mol Ther 2: 539-544, 2000.
21. Liu J, Zou WG, Lang MF, et al: Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int J Oncol 21: 661-666, 2002.
22. Takakura M, Kyo S, Kanaya T, et al : Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 59: 551-557, 1999. (Pubitemid 29076049)
23. Horikawa I, Cable PL, Afshari C and Barrett JC: Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res 59: 826-830, 1999. (Pubitemid 29086735)
24. Dolph PJ, Huang JT and Schneider RJ: Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex. J Virol 64: 2669-2677, 1990. (Pubitemid 20171253)
25. Huang W and Flint SJ: The tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export. J Virol 72: 225-235, 1998. (Pubitemid 28048832)
26. Logan J and Shenk T: Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection. Proc Natl Acad Sci USA 81: 3655-3659, 1984. (Pubitemid 14087783)
27. Lee WW, Lee B, Kim SJ, Jin J, Moon DH and Lee H: Kinetics of iodide uptake and efflux in various human thyroid cancer cells by expressing sodium iodide symporter gene via a recombinant adenovirus. Oncol Rep 10: 845-849, 2003.
28. Shin JH, Yi JK, Lee YJ, et al : Development of artificial chimerical gene regulatory elements specific for cancer gene therapy. Oncol Rep 10: 2063-2069, 2003.
29. Lee WW, Moon DH, Park SY, Jin J, Kim SJ and Lee H: Imaging of adenovirus-mediated expression of human sodium iodide symporter gene by 99mTcO4 scintigraphy in mice. Nucl Med Biol 31: 31-40, 2004. (Pubitemid 38115123)
30. Yoon DW, Lee H, Seol W, De Maria M, Rosenzweig M and Jung JU: Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. Immunity 6: 571-582, 1997. (Pubitemid 27239348)
31. Kang HC, Chae JH, Lee YH, et al : Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family. Mol Cell Biol 25: 6005-6020, 2005. (Pubitemid 40946554)
32. Lee H, Kim J, Lee B, et al: Oncolytic potential of E1B 55 kDa-deleted YKL-1 recombinant adenovirus: correlation with p53 functional status. Int J Cancer 88: 454-463, 2000.
33. Komata T, Kondo Y, Kanzawa T, et al: Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter. Cancer Res 61: 5796-5802, 2001. (Pubitemid 32769097)
34. Cerni C: Telomeres, telomerase and myc. An update. Mutat Res 462: 31-47, 2000.
35. Wang J, Xie LY, Allan S, Beach D and Hannon GJ: Myc activates telomerase. Genes Dev 12: 1769-1774, 1998. (Pubitemid 28304329)
36. Kim E, Kim JH, Shin HY, et al : Ad-mTERT-delta19, a conditional replication-competent adenovirus driven by the human telomerase promoter, selectively replicates in and elicits cytopathic effect in a cancer cell-specific manner. Hum Gene Ther 14: 1415-1428, 2003. (Pubitemid 37268220)
37. Su CQ, Sham J, Xue HB, et al: Potent antitumoral efficacy of a novel replicative adenovirus CNHK300 targeting telomerasepositive cancer cells. J Cancer Res Clin Oncol 130: 591-603, 2004. (Pubitemid 39371329)