E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 9538-9548

  Pützer, Brigitte M ^a,b   Rumpf, Heike ^a   Rega, Susanne ^a   Brockmann, Dieter ^a   Esche, Helmut ^a  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN;

ADENOVIRUS; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENICITY; CELL CYCLE; CELL TRANSFORMATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; PRIORITY JOURNAL; PROMOTER REGION; SEQUENTIAL ANALYSIS; TRANSACTIVATION;

EID: 1842364871     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.9538-9548.1997     Document Type: Article

References (66)

1. Babich, A., and J. R. Nevins. 1981. The stability of early adenovirus mRNA is controlled by the viral 72 kD DNA-binding protein. Cell 26:371-379.
2. Barbeau, D., R. Charbonneau, S. G. Whalen, S. T. Bayley, and P. E. Branton. 1994. Functional interactions within adenovirus E1A protein complexes. Oncogene 9:359-373.
3. Barrett, P., L. Clark, and R. T. Hay. 1987. A cellular protein binds to a conserved sequence in the adenovirus type 2 enhancer. Nucleic Acids Res. 15:2719-2735.
4. Blake, M. C., and J. C. Azizkhan. 1989. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol. 11:4994-5002.
5. Brockmann, D., B. Tries, and H. Esche. 1990. Isolation and characterization of novel adenovirus type 12 mRNAs by cDNA PCR technique. Virology 179:585-590.
6. b) activity by the adenovirus type 12-unique 52R E1A protein. J. Biol. Chem. 270:10754-10763.
7. Buchkovich, K., N. Dyson, P. Whyte, and E. Harlow. 1990. Cellular proteins that are targets for transformation by DNA tumour viruses. Ciba Found. Symp. 150:271-278.
8. Byrd, P. J., R. J. Grand, and J. H. Gallimore. 1988. Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras. Oncogene 2:477-484.
9. Cao, L., B. Faha, M. Dembski, L.-H. Tsai, E. Harlow, and N. Dyson. 1992. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 355:176-179.
10. Chellappan, S. P., S. Hiebert, M. Mudryj, J. M. Horowitz, and J. R. Nevins. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053-1061.
11. Christensen, J. B., and M. J. Imperiale. 1995. Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen. J. Virol. 65:3945-3948.
12. Claudio, P. P., C. M. Howard, A. Baldi, A. De Luca, Y. Fu, G. Condorelli, Y. Sun, N. Colburn, B. Calabretta, and A. Giordano. 1994. p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res. 54:5556-5560.
13. Corbeil, H. B., P. Whyte, and P. E. Branton. 1995. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene 11:909-920.
14. Dalton, S. 1992. Cell cycle regulation of the human cdc2 gene. EMBO J. 11:1797-1804.
15. Dorsman, J. C., A. F. A. S. Teunisse, A. Zantema, and A. J. van der Eb. 1997. The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription coactivator family, including the CREB-binding protein CBP and p300. J. Gen. Virol. 78:423-426.
16. Egan, C., S. T. Bayley, and P. E. Branton. 1989. Binding of the Rb1 protein to E1A products is required for adenovirus transformation. Oncogene 4: 383-388.
17. Fattaey, A. R., E. Harlow, and K. Helin. 1993. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13:7267-7277.
18. Gallimore, P., P. Byrd, R. Grand, J. Whittaker, D. Breiding, and J. Williams. 1984. An examination of the transforming and tumor-inducing capacity of a number of adenovirus type 12 early region 1, host-range mutants and cells transformed by subgenomic fragments of Ad12 E1 region. Cancer Cells 2:519-526.
19. Giordano, A., C. McCall, P. Whyte, and B. R. Franza. 1991. Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product. Oncogene 6:481-485.
20. Glenn, G. M., and R. P. Ricciardi. 1988. Detailed kinetics of adenovirus type 5 steady-state transcripts during early infection. Virus Res. 9:73-91.
21. Harlow, E., P. Whyte, B. R. Franza, and C. Schley. 1986. Association of adenovirus early region 1A proteins with cellular polypeptides. Mol. Cell. Biol. 6:1579-1589.
22. Haupenthal, C., D. Brockmann, and H. Esche. Unpublished data.
23. Herrmann, C. H., L.-K. Su, and E. Harlow. 1991. Adenovirus E1A is associated with serine/threonine protein kinase. J. Virol. 65:5848-5859.
24. Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6:177-185.
25. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
26. Houweling, A., P. J. van den Elsen, and A. J. van der Eb. 1980. Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. Virology 105:537-550.
27. Howe, J. A., and S. T. Bayley. 1992. Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A. Virology 186:15-24.
28. Jelinek, T., and F. L. Graham. 1992. Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad)2 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range. J. Virol. 66:4117-4125.
29. Jelinek, T., D. S. Pereira, and F. L. Graham. 1994. Tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1A. J. Virol. 68:888-896.
30. Jelsma, T. N., J. A. Howe, J. S. Mymryk, C. M. Evelegh, N. F. A. Cunniff, and S. T. Bayley. 1989. Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen. Virology 171:120-130.
31. Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349-352.
32. Kim, Y. K., and A. S. Lee. 1991. Identification of a 70-base-pair cell cycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors. Mol. Cell. Biol. 11:2296-2302.
33. Kirch, H. C., B. Pützer, G. Schwabe, H. Krüger, A. Gnauck, and H. Schulte Holthausen. 1993. Regulation of adenovirus 12 E1A transcription: E2F and ATF motifs in the E1A promoter bind nuclear protein complexes including E2F1, DP-1, cyclin A and/or RB and mediate transcriptional (auto)activation. Cell. Mol. Biol. Res. 39:705-716.
34. Kleinberger, T., and T. Shenk. 1991. A protein kinase is present in a complex with adenovirus E1A proteins. Proc. Natl. Acad. Sci. USA 88:11143-11147.
35. Lamberti, C., and J. Williams. 1990. Differential requirement for adenovirus type 12 E1A gene products in oncogenic transformation. J. Virol. 64:4997-5007.
36. Larose, A., N. Dyson, M. Sullivan, E. Hartow, and M. Bastin. 1991. Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization. J. Virol. 65:2308-2313.
37. Lavery, D. J., and S. Chen-Kiang. 1990. Adenovirus E1A and E1B genes are regulated posttranscriptionally in human lymphoid cells. J. Virol. 64:5349-5359.
38. Lewis, J. B., and M. B. Mathews. 1980. Control of adenovirus early gene expression: a class of immediate early products. Cell 21:303-313.
39. Licht, J. D., M. J. Grossel, J. Figge, and U. M. Hansen. 1990. Drosophila kruppel protein is a transcriptional repressor. Nature 346:76-79.
40. Manohar, C. F., J. Kratochvil, and B. Thimmapaya. 1990. The adenovirus EII early promoter has multiple E1A-sensitive elements, two of which function cooperatively in basal and virus-induced transcription. J. Virol. 64:2457-2466.
41. Mayol, X., X. Grana, A. Baldi, N. Sang, N. S. Hu, and A. Giordano. 1993. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8:2561-2566.
42. Moran, E. 1993. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 3:63-70.
43. Murphy, M., B. Opalka, R. Sajaczkowski, and H. Schulte Holthausen. 1987. Definition of a region required for transformation in E1A of adenovirus 12. Virology 159:49-56.
44. Neumann, J. R., C. A. Morency, and K. O. Russian. 1987. A novel rapid assay for chloramphenicol acetyltransferase gene expression. BioTechniques 5: 444-447.
45. Opalka, B. Personal communication.
46. Pearson, B. E., H. P. Nasheuer, and T. S. Wang. 1991. Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol. 11:2081-2095.
47. Phelps, W. C., S. Bagchi, J. A. Barnes, P. Raychaudhuri, V. Kraus, K. Muenger, P. M. Howley, and J. R. Nevins. 1991. Analysis of transactivation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. J. Virol. 65:6922-6930.
48. Pützer, B. M., A. Gnauck, H. C. Kirch, D. Brockmann, and H. Esche. 1997. A cis-acting element 7 base pairs upstream of the ESF-1-binding motif is involved in E1A 13S autoregulation of the adenovirus 12 TS2 promoter. J. Gen. Virol. 78:879-891.
49. Raychaudhuri, P. S., S. Bagchi, S. H. Devoto, V. B. Kraus, E. Moran, and J. R. Nevins. 1991. Domains of the adenovirus E1A protein that are required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev. 5:1200-1211.
50. Salewski, E., G. Werner, B. Opalka, E. Schwarz, and H. Schulte Holthausen. 1989. Genome structure of adenovirus host range mutants adapted to growth in simian Vero cells. Intervirology 30:44-51.
51. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
52. Shirodkar, S., M. Ewen, J. A. DeCaprio, J. Morgan, D. M. Livingston, and T. Chittenden. 1992. The transcriptional factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68:157-166.
53. Slansky, J., Y. Li, W. G. Kaelin, and P. J. Farnham. 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13:1610-1618.
54. Smits, P. H. M., L. de Witt, A. J. van der Eb, and A. Zantema. 1996. The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation. Oncogene 12:1529-1535.
55. Solnick, D., and M. A. Anderson. 1982. Transformation-deficient adenovirus mutant defective in expression of region 1A but not region 1B. J. Virol. 42:106-113.
56. Subrumanian, T., M. Kuppuswamy, R. J. Nasr, and G. Chinnadurai. 1988. An N-terminal region of adenovirus E1A essential for transformation and induction of an epithelial cell growth factor. Oncogene 2:105-112.
57. Telling, G. C., and J. Williams. 1994. Construction of chimeric type 12/type 5 adenovirus E1A genes and using them to identify an oncogenic determinant of adenovirus 12. J. Virol. 68:877-887.
58. Van den Hoff, M. J. B., A. F. M. Moorman, and W. H. Lamers. 1992. Electroporation intracellular buffer increases cell survival. Nucleic Acids Res. 20:2902.
59. van der Eb, A. J., C. Mulder, F. L. Graham, and A. Houweling. 1977. Transformation with specific fragments of adenovirus DNAs. I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. Gene 2:115-132.
60. Wang, H.-G. H., P. Yaciuk, R. P. Ricciardi, M. Green, K. Yokoyama, and E. Moran. 1993. The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300. J. Virol. 67:4804-4813.
61. Werner, G., and H. zur Hausen. 1978. Deletions and insertions in adenovirus type 12 DNA after viral replication in Vero cells. Virology 86:66-77.
62. Whyte, P., H. E. Ruley, and E. Harlow. 1988. Two regions of the adenovirus early region IA proteins are required for transformation. J. Virol. 62:257-265.
63. Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
64. Wolf, D. A., H. Hermeking, T. Albert, P. Kind, and D. Eick. 1995. A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. Oncogene 10: 2067-2078.
65. Yee, S.-Y., and P. E. Branton. 1985. Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides. Virology 147: 142-153.
66. Zalvide, J., and J. A. DeCaprio. 1995. Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol. Cell. Biol. 15:5800-5810.