The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues

International Journal of Oncology

Volumn 29, Issue 4, 2006, Pages 957-964

  Kraus, Magdalena C ^a   Seelig, Matthias H ^b   Linnemann, Ulrich ^c   Berger, Martin R ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b ST JOSEF HOSPITAL   (Germany)

^c Municipal Hospital Nürnberg Nord   (Germany)

Author keywords

Colorectal cancer; Colorectal polyp; Inconspicuous mucosa; K ras mutations; PCR RFLP

Indexed keywords

DNA;

AGED; ARTICLE; CARCINOMA; CHEMISTRY; CODON; COLORECTAL TUMOR; COMPARATIVE STUDY; FEMALE; GENETICS; HUMAN; INTESTINE MUCOSA; MALE; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOLOGY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

AGED; CARCINOMA; CODON; COLORECTAL NEOPLASMS; DNA; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENES, RAS; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 39049189749     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.29.4.957     Document Type: Article

References (23)

1. Bishop JM: Molecular themes in oncogenesis. Cell 64: 235-248, 1991.
2. Bos JL, Fearon ER, Hamilton SR, et al: Prevalence of ras gene mutations in human colorectal cancers. Nature 327: 293-297, 1987.
3. Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532, 1988.
4. Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
5. Kiaris H and Spandidos DA: Mutations of ras genes in human tumours (Review). Int J Oncol 7: 413-421, 1995.
6. Finkelstein SD, Sayegh R, Bakker A and Swalsky P: Determination of tumor aggressiveness in colorectal cancer by K-ras-2 analysis. Arch Surg 128: 526-531, 1993.
7. Brink M, De Goeij AF, Weijenberg MP, et al: K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis 24: 703-710, 2003.
8. Andreyev HJ, Norman AR, Cunningham D, et al: Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer 85: 692-696, 2001.
9. Samowitz WS, Curtin K, Schaffer D, Robertson M, Leppert M and Slattery ML: Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prev 9: 1193-1197, 2000.
10. Bazan V, Migliavacca M, Zanna I, et al: Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol 13: 1438-1446, 2002.
11. Slattery ML, Anderson K, Curtin K, et al: Lifestyle factors and Ki-ras mutations in colon cancer tumors. Mutat Res 483: 73-81, 2001.
12. Schimanski CC, Linnemann U and Berger MR: Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver. Cancer Res 59: 5169-5175, 1999.
13. Dieterle CP, Conzelmann M, Linnemann U and Berger MR: Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients. Clin Cancer Res 10: 641-650, 2004. (Pubitemid 38174004)
14. Guerrero S, Casanova I, Farre L, Mazo A, Capella G and Mangues R: K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res 60: 6750-6756, 2000.
15. Vizan P, Boros LG, Figueras A, et al: K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice (corrected) fibroblasts. Cancer Res 65: 5512-5515, 2005.
16. Conzelmann M, Linnemann U and Berger MR: K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients. Int J Oncol 24: 1537-1544, 2004.
17. Andreyev HJ, Norman AR, Cunningham D, Oates JR and Clarke PA: Kirsten ras mutations in patients with colorectal cancer: the multicenter 'RASCAL' study. J Natl Cancer Inst 90: 675-684, 1998.
18. Al-Mulla F, Milner-White EJ, Going JJ and Birnie GD: Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression. J Pathol 187: 433-438, 1999. (Pubitemid 29118275)
19. Greenblatt MS, Bennett WP, Hollstein M and Harris CC: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878, 1994. (Pubitemid 24289415)
20. Morinello EJ, Koc H, Ranasinghe A and Swenberg JA: Differential induction of N(2),3-ethenoguanine in rat brain and liver after exposure to vinyl chloride. Cancer Res 62: 5183-5188, 2002. (Pubitemid 35024589)
21. Qi J, Zhu YQ, Huang MF and Yang D: Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor. World J Gastroenterol 11: 2022-2025, 2005.
22. Shu J, Schellhorn HE and Murphy TM: Stationary phase-induction of G→T mutations in Escherichia coli. Mutat Res (Epub ahead of print) doi:10.1016/ j.mrfmmm.2005.12.015.
23. Barbin A: Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra. Mutat Res 462: 55-69, 2000.