DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible cytotoxicity

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 650, Issue 2, 2008, Pages 104-114

  Di Giorgio, Carole ^a   Nikoyan, Anna ^a   Decome, Laetitia ^a   Botta, Céline ^a   Robin, Maxime ^a   Reboul, Jean Pierre ^a   Sabatier, Anne Sophie ^a   Matta, Alain ^a   De Méo, Michel ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Comet assay; Cytotoxicity; DNA binding activity; In vitro micronuclei; Photoactivation; QSAR; Salmonella mutagenicity test; Simulated sunlight; Thiazolo acridines

Indexed keywords

2 CHLORO 6 NITROBENZOTHIAZOLE; ACRIDINE DERIVATIVE; ACRIDINE ORANGE; METHYL GREEN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CHROMOSOME DAMAGE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIGHT; MALE; METABOLIC ACTIVATION; MICRONUCLEUS TEST; MUTAGENICITY; NONHUMAN; PHOTOACTIVATION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SALMONELLA;

ACRIDINES; CELL SURVIVAL; CELLS, CULTURED; DNA DAMAGE; HUMANS; INTERCALATING AGENTS; LIGHT; MUTAGENICITY TESTS; MUTAGENS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

GALIUM APARINE; SALMONELLA;

EID: 39049169634     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.10.022     Document Type: Article

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