Diverse mutagenicity of methylbenz[c]acridines in the direct Ames' salmonella mutagenicity assay

Anticancer Research

Volumn 16, Issue 5 A, 1996, Pages 2837-2841

  Tanaka, Masaru ^a   Csuri, Klara ^a   Molnar, Joseph ^a   Motohashi, Noboru ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Ames' test; Benz c acridines; Mutagenicity

Indexed keywords

ACRIDINE DERIVATIVE; METHYL GROUP;

AMES TEST; ARTICLE; BACTERIUM COLONY; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE MUTATION; MUTAGENICITY; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SALMONELLA;

ACRIDINES; MUTAGENICITY TESTS; SALMONELLA TYPHIMURIUM;

EID: 0029859069     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Dipple A: Polycyclic aromatic hydrocarbon carcinogenesis. In: Hary RG (ed.): "Polycyclic Hydrocarbons and Carcinogenesis." Washigton DC: American Chemical Society, 1985, pp 117.
2. Grimmer G, Naujack KW, Dettbarn G: Gaschromatographic determination of polycyclic aromatic hydrocarbons, aza-arenes, aromatic amines in the particle and vapor phase of mainstream and sidestream smoke of cigarettes. Toxicol Lett 35: 117-124, 1987.
3. Kotin P: The role of atmospheric pollution in the pathogenesis of pulmonary cancer: a review. Cancer Res 16: 375-393, 1956.
4. Motohashi N, Kamata K, Meyer R: Chromatographic techniques used to determine benz[c]acridines in environmental samples. J Chromatogr 643: 1-10, 1993.
5. Lacassagne A, Buu-Hoi NP, Daudel R, Zajdela F: The relation between carcinogenic activity and the physical and chemical properties of angular benzacridines. Adv Cancer Res 4: 315-369, 1956.
6. Walker BA, Rogan EG, Cromwell NH: Mutagenicity of selected functionalized benz[c]acridines and a benz[a]phenazine in the Salmonella typhimurium/microsome assay. Anticancer Res 4: 399-402, 1984.
7. Motohashi N, Kamata K: A convenient method of the purification for carcinogenic and noncarcinogenic methylsubstituted benz[c]-acridines. (In Japanese) Yakugaku Zasshi 103: 795-799, 1983.
8. Maron DM, Ames BN: Revised methods for the Salmonella mutagenicity test. Mutat Res 113: 173-215, 1983.
9. Lowe JP, Silverman BD: Heteroatom effects in chemical carcinogenesis: effects of ring heteroatoms on case of carbocation formation. Cancer Biochem Biophys 7: 53-60, 1983.
10. Okano T, Horie T, Motohashi N, Watanabe Y, Nishimiya Y: Electronic interaction of carcinogenic and noncarcinogenic benz[c]acridines and DNA. Gann 66: 529-537, 1975.
11. Kamata K, Motohashi N: Interaction of 7, 10-dimethylbenz[c]-acridine with deoxyribonucleic acid. Bull Environ Contam Toxicol 43: 534-540, 1989.
12. Kamata K, Motohashi N: Raman spectra of methyl substituted benz[c]acridines and their complexes with DNA. Anticancer Res 9: 579-582, 1989.
13. Okano T, Horie T, Iwaizumi M, Motohashi N: Formation of free radicals from carcinogenic benz[c]acridines in the presence of proteins. Gann 69: 109-114, 1978.
14. 1H NMR spectra of methylbenz[c]acridines. Neoplasma 33: 313-322, 1986.
15. Okano T, Haga M, Ujiie K, Motohashi N: Half-wave potentials and LCAO-SCF-MO calculations for carcinogenic benz[c]acridines. Chem Pharm Bull 26: 2855-2859, 1978.
16. Okano T, Horie T, Koike T, Motohashi N: Relationship of carcinogenicity, mutagenicity and K-region reactivity in benz[c]acridines. Gann 70: 749-754, 1979.
17. Motohashi N, Kurihara T, Sakagami H, Molnar J: Relationship between resonance energy and carcinogenic activity of benz[c]acridine. Anticancer Res 12: 2105-2108, 1992.
18. Kurihara T, Sakagami H, Molnar J, Motohashi N: Quantumchemical structure of carcinogenic benz[c]acridines. Anticancer Res 14: 1811-1822, 1994.
19. Molnar J, Petofi S, Kurihara T, Sakagami H, Motohashi N: Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds. Anticancer Res 13: 263-266, 1993.
20. Levin W, Wood AW, Chang RL, Kumar S, Yagi H, Jerina DM, Lehr RE, Conney AH: Tumor-initiating activity of benz[c]acridine and twelve of its derivatives on mouse skin. Cancer Res 43: 4625-4628, 1983.
21. Chang RL, Levin W, Wood AW, Kumar S, Yagi H, Jerina DM, Lehr RE, Conney AH: Tumorigenicity of dihydrodiols and diol-epoxides of benz[c]acridine in newborn mice. Cancer Res 44: 5161-5164, 1984.
22. Chang RL, Levin W, Wood AW, Shirai N, Ryan AJ, Duke CC, Jerina DM, Holder GM, Conney AH: High tumorigenicity of the 3, 4-dihydrodiol of 7-methylbenz[c]acridine on mouse skin and in newborn mice. Cancer Res 46: 4552-4555, 1986.
23. Levin DE, Yamasaki E, Ames BN: A new Salmonella tester strain, TA97, for the detection of frameshift mutagens. Mutat Res 94: 315-330, 1982.
24. Isono K, Yourno J: Chemical carcinogens as frameshift mutagens: Salmonella DNA sequence sensitive to mutagenesis by polycyclic carcinogenesis. Proc Nat Acad Sci USA 71(5): 1612-1617, 1974.
25. + revertants of the G46 missense mutation in Salmonella typhimurium. Environ Mutagen 4: 297 (abstr. Aa-1), 1982.
26. Levin DE, Hollstein M, Christman MF, Schwiers EA, Ames BN: A new Salmonella tester strain (TA102) with AT base pairs at the site of mutation detects oxidative mutagens. Proc Natl Acad Sci USA 79: 7445-7449, 1982.