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Volumn 14, Issue 1, 2001, Pages 1-10

Products of metabolic activation of the antitumor drug ledakrin (Nitracrine) in vitro

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOACRIDINONE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DITHIOTHREITOL; HYDRAZINE; NITRACRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TIN CHLORIDE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

EID: 0035148495     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000081c     Document Type: Article
Times cited : (36)

References (13)
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  • 2
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    • World Health Organization, Geneva
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  • 3
    • 0017037616 scopus 로고
    • Preliminary observations of the ledakrin effect in treatment of patients with lung carcinoma
    • Kwaśniewska-Rokicimska, C., Sawicki, J., and Drosik, K. (1976) Preliminary observations of the ledakrin effect in treatment of patients with lung carcinoma. Mater. Med. Pol. (Engl. Ed.) 8, 289-294.
    • (1976) Mater. Med. Pol. (Engl. Ed.) , vol.8 , pp. 289-294
    • Kwaśniewska-Rokicimska, C.1    Sawicki, J.2    Drosik, K.3
  • 5
    • 0014460464 scopus 로고
    • In vitro studies on the cytotoxic properties of 9-aminoacridine derivatives
    • Konopa, J., Ledóchowski, A., Matuszkiewicz, A., and Jereczek-Morawska, E. (1969) In vitro studies on the cytotoxic properties of 9-aminoacridine derivatives. Neoplasma 16, 171-179.
    • (1969) Neoplasma , vol.16 , pp. 171-179
    • Konopa, J.1    Ledóchowski, A.2    Matuszkiewicz, A.3    Jereczek-Morawska, E.4
  • 7
    • 0021276457 scopus 로고
    • QSAR of acridines. I. Search for antitumor derivatives of 1-nitro-9-(3′-aminopropylamino)acridine
    • Mazerska, Z., and Ledóchowski, A. (1984) QSAR of acridines. I. Search for antitumor derivatives of 1-nitro-9-(3′-aminopropylamino)acridine. Eur. J. Med. Chem. 19, 199-204.
    • (1984) Eur. J. Med. Chem. , vol.19 , pp. 199-204
    • Mazerska, Z.1    Ledóchowski, A.2
  • 8
    • 0025232660 scopus 로고
    • Antitumor activity of 1-nitro-9-aminoacridine derivatives, including Nitracrine, against some ascitic experimental tumors
    • Mazerska, Z., Łukowicz, J., and Konopa, J. (1990) Antitumor activity of 1-nitro-9-aminoacridine derivatives, including Nitracrine, against some ascitic experimental tumors. Arzneim.-Forsch. 40, 472-477.
    • (1990) Arzneim.-Forsch. , vol.40 , pp. 472-477
    • Mazerska, Z.1    ŁUkowicz, J.2    Konopa, J.3
  • 9
    • 0025009973 scopus 로고
    • QSAR of acridines. II. Features of Nitracrine analogs for high antitumor activity and selectivity on mice, searched by PCA and MRA methods
    • Mazerska, Z., Mazerski, J., and Ledóchowski, A. (1990) QSAR of acridines. II. Features of Nitracrine analogs for high antitumor activity and selectivity on mice, searched by PCA and MRA methods. Anti-Cancer Drug Des. 5, 169-187.
    • (1990) Anti-Cancer Drug Des. , vol.5 , pp. 169-187
    • Mazerska, Z.1    Mazerski, J.2    Ledóchowski, A.3
  • 10
    • 0018580465 scopus 로고
    • 14C-(3′-dimethylamino-N-propylamino)acridine, a new antitumor and DNA cross-linking agent, to macromolecules of subcellular fractions isolated from rat liver and HeLa cells
    • 14C-(3′-dimethylamino-N-propylamino)acridine, a new antitumor and DNA cross-linking agent, to macromolecules of subcellular fractions isolated from rat liver and HeLa cells. Biochem. Pharmacol. 28, 3391-3402.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 3391-3402
    • Pawlak, J.W.1    Konopa, J.2
  • 11
    • 0020701358 scopus 로고
    • The mode of action of cytotoxic and antitumor 1-nitroacridines. II. in vitro enzyme mediated covalent binding of a 1-nitroacridine derivative Ledakrin or Nitracrine with DNA and other macromolecules of mammalian or bacterial cells
    • Pawlak, J. W., Pawlak, K., and Konopa, J. (1983) The mode of action of cytotoxic and antitumor 1-nitroacridines. II. In vitro enzyme mediated covalent binding of a 1-nitroacridine derivative Ledakrin or Nitracrine with DNA and other macromolecules of mammalian or bacterial cells. Chem.-Biol. Interact. 43, 151-173.
    • (1983) Chem.-Biol. Interact. , vol.43 , pp. 151-173
    • Pawlak, J.W.1    Pawlak, K.2    Konopa, J.3
  • 12
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    • DNA damage and cytotoxicity of nitracrine in cultured HeLa cells
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    • Szmigiero, L.1    Studzian, K.2
  • 13
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    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1301-1312
    • Bartoszek, A.1    Konopa, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.