Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

Journal of Biomolecular Screening

Volumn 13, Issue 2, 2008, Pages 120-127

  Titus, Steve ^a   Neumann, Susanne ^b   Wei Zheng, ^a   Southall, Noel ^a   Michael, Sam ^a   Klumpp, Carleen ^a   Yasgar, Adam ^a   Shinn, Paul ^a   Thomas, Craig J ^a   Inglese, James ^a   Gershengorn, Marvin C ^b   Austin, Christopher P ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

CNG; HTS; Probe identification; PubChem; qHTS; Quantitative high throughput screening; Thyroid stimulating hormone; TSH; TSHR; TSHR agonist

Indexed keywords

CYCLIC AMP; GLYCOPROTEIN; HORMONE RECEPTOR; ION CHANNEL; MEMBRANE RECEPTOR; RECOMBINANT THYROTROPIN; THYROID STIMULATING HORMONE RECEPTOR AGONIST; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOSENSOR; CELL GROWTH; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; FLUORESCENCE; GENE EXPRESSION; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HORMONAL REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THYROID CANCER; THYROID FOLLICLE CELL;

ALGORITHMS; CALIBRATION; CELLS, CULTURED; CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; FALSE POSITIVE REACTIONS; HUMANS; MINIATURIZATION; MODELS, BIOLOGICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, THYROTROPIN; SMALL MOLECULE LIBRARIES; TRANSFECTION;

EID: 39049154305     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057107313786     Document Type: Article

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