Defective thyrotropin receptor G-protein cyclic adenosine monophosphate signaling mechanism in the FTC human follicular thyroid cancer cell line

Surgery

Volumn 122, Issue 6, 1997, Pages 1195-1202

  Demeure, Michael J ^a,b   Doffek, Kara M ^a,b   Wilson, Stuart D ^a,b  

^a Medical College of Wisconsin ^*

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; FIBRONECTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; THYROTROPIN RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DENSITOMETRY; ENZYME ACTIVATION; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; THYROID FOLLICULAR CARCINOMA;

EID: 0031445135     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6060(97)90227-0     Document Type: Article

References (23)

1. Vassart G, Dumont JE. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocrinol Rev 1992;13:596-611.
2. Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, et al. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 1993;365:649-51.
3. Matsuo K, Friedman E, Gejman PV, Fagin JA. The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms. J Clin Endocrinol Metab 1993;76:1446-51.
4. Ohno M, Endo T, Ohta K, Gunji K, Onaya T. Point mutations in the thyrotropin receptor in human thyroid tumors. Thyroid 1995;5:97-100.
5. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylate cyclase in human pituitary tumors. Nature 1989;340:692-6.
6. Siperstein AE, Miller RA, Landis C, Bourne H, Clark OH. Increased stimulatory G protein in neoplastic human thyroid tissues. Surgery 1991;110:949-55.
7. Packman KS, Demeure MJ, Doffek KM, Wilson SD. Increased plasminogen activator and type IV collagenase activity in invasive follicular thyroid carcinoma cells. Surgery 1995;118:1011-6.
8. Hoelting T, Tezelman S, Siperstein AE, Duh QY, Clark OH. Thyrotropin stimulates invasion and growth of follicular thyroid canacer cells via PKC-rather than PKA-activation. Biochem Biophys Res Commun 1993;195:1230-6.
9. Demeure MJ, Damsky CH, Elfman F, Goretzki PE, Wong MG, Clark OH. Invasion by cultured follicular thyroid cancer correlates with increased beta-1 integrins and production of proteases. World J Surg 1992;16:770-6.
10. Goretzki PE, Frilling A, Simon D, et al. Growth regulation of human thyrocytes by thyrotropin, cyclic adenosine monophosphate, epidermal growth factor and insulin-like growth factor. Front Horm Res 1989;18:56-80.
11. Derwahl M, Kuemmel M, Goretzki P, Schatz H, Boecker M. Expression of the human TSH receptor in a human thyroid carcinoma cell line that lacks an endogenous TSH receptor: growth inhibition by cAMP. Biochem Biophys Res Commun 1993;191:1131-8.
12. Goretzki PE, Frilling A, Simon D, Roeher D. Growth reglation of normal thyroids and thyroid tumors in man. Recent Results Cancer Res 1990;118:48-63.
13. Lowry OH, Rosebrough NJ, Farr AL, Randell RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
14. Laemmli UK. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
15. Matsudaira P. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J Biol Chem 1987;262:10035-8.
16. Kozasa T, Itoh H, Tsukamoto R, Kaziro Y. Isolation and characterization of the human Gsa gene. Proc Natl Acad Sci USA 1988;85:2081-5.
17. Bidey SP, Marshall NJ, Ekins RP. Characterization of cyclic AMP response to thyrotropin in monolayer cultures of normal human thyroid cells. Acta Endocrinol 1981;98:370-6.
18. Kosugi S, Mori T. The intracellular region adjacent to plasma membrane (residues 684-692) of the thyrotropin receptor is important for phosphoinositide signaling but not for agonist-induced adenylate cyclase activation. Biochem Biophys Res Commun 1994;199:1497-503.
19. Hay ID, Feld S, Garcia M, et al. AACE clinical practice guidelines for the management of thyroid carcinoma. Endocrinol Pract 1997;3:60-71.
20. Kimura T, Yamashita S, Namba H, et al. Impairment of the TSH signal transduction system in human thyroid carcinoma cells. Exp Cell Res 1992:203:402-6.
21. 2+-phosphatidylinositol cascade of human thyrocytes in primary culture. Mol Cell Endocrinol 1991;81:175-83.
22. 2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. J Clin Endocrinol Metab 1994;79:152-9.
23. Hoelting T, Tezelman S, Siperstein A, Duh QY, Clark OH. Biphasic effects of thyrotropin on invasion and growth of papillary and follicular thyroid cancer in vitro. Thyroid 1995;5:35-40.