Discovery of novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1340-1345

  Yang, Huaiyu ^a   Dou, Wei ^a   Lou, Jing ^a   Leng, Ying ^a   Shen, Jianhua ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

11 HSD1; 11 HSD2; Docking; Inhibitor; Pharmacophore

Indexed keywords

11 BETA HYDROXYSTEROID DEHYDROGENASE 1; 11 BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; ENZYME; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; DIABETES MELLITUS; DRUG POTENCY; DRUG STRUCTURE; ENZYME ASSAY; METABOLIC SYNDROME X; PHARMACOPHORE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39049147112     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.020     Document Type: Article

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