Short report: Polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine

American Journal of Tropical Medicine and Hygiene

Volumn 77, Issue 6, 2007, Pages 1034-1038

  Echeverry, Diego F ^a   Holmgren, Gabrielle ^b   Murillo, Claribel ^a   Higuita, Juan C ^c   Björkman, Anders ^b   Gil, Jose P ^b   Osorio, Lyda ^a  

^a CENTRO INTERNACIONAL DE ENTRENAMIENTO E INVESTIGACIONES MÉDICAS CIDEIM   (Colombia)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; CHLOROQUINE; DEETHYLAMODIAQUINE; ANTIMALARIAL AGENT; CARRIER PROTEIN; DRUG DERIVATIVE; MDR1 PROTEIN, PLASMODIUM FALCIPARUM; MULTIDRUG RESISTANCE PROTEIN; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COLOMBIA; GENE; GENE MUTATION; GENETIC POLYMORPHISM; HAPLOTYPE; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PFCRT GENE; PFMDR1 GENE; PLASMODIUM FALCIPARUM; SINGLE NUCLEOTIDE POLYMORPHISM; AMINO ACID SEQUENCE; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; DRUG SENSITIVITY; GENETICS; IC 50; MOLECULAR GENETICS;

PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; AMODIAQUINE; ANIMALS; ANTIMALARIALS; BASE SEQUENCE; COLOMBIA; DRUG RESISTANCE; INHIBITORY CONCENTRATION 50; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS;

EID: 39049132986     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2007.77.1034     Document Type: Article

References (31)

1. World Health Organization, 2001. The Use of Antimalarial Drugs. Report of a WHO Informal Constitution. Geneva: Roll BacK Malaria/WHO.
2. Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, Olliaro P, 1999. Amodiaquine remains effective for treating uncomplicated malaria in west and central Africa. Trans R Soc Trop Med Hyg 93: 645-650.
3. Adjuik M BA, Garner P, Olliaro P, Taylor W, White N, International Artemisinin Study Group, 2004. Artesunate combinations for treatment of malaria: meta-analysis. Lancet 363: 9-17.
4. Ministry of Health of Colombia, 1999. Guide for the Clinical Attention, Diagnosis and Treatment of Malaria. Santafé de Bogotá D.C.: General Direction of Health Promotion and Prevention.
5. Li XQ, Bjorkman A, Andersson TB, Ridderstrom M, Masimirembwa CM, 2002. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther 300: 399-407.
6. Churchill FC, Patchen LC, Campbell CC, Schwartz IK, Nguyen-Dinh P, Dickinson CM, 1985. Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans. Life Sci 36: 53-62.
7. Hombhanje FW, Tsukahara T, Saruwatari J, Nakagawa M, Osawa H, Paniu MM, Takahashi N, Lum JK, Aumora B, Masta A, Sapuri M, Kobayakawa T, Kaneko A, Ishizaki T, 2004. The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria. Br J Clin Pharmacol 59: 1-4.
8. Chen N, Russell B, Staley J, Kotecka B, Nasveld P, Cheng Q, 2001. Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum. J Infect Dis 183: 1543-1545.
9. Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, Coulibaly D, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344: 257-263.
10. Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6: 861-871.
11. Ochong EO, van den Broek IV, Keus K, Nzila A, 2003. Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan. Am J Trop Med Hyg 69: 184-187.
12. Holmgren G, Gil JP, Ferreira PM, Veiga MI, Obonyo CO, Bjorkman A, 2006. Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y. Infect Genet Evol 6: 309-314.
13. Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM, 2006. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. Am J Trop Med Hyg 75: 155-161.
14. Gonzalez IJ, Padilla JO, Giraldo LE, Saravia NG, 2003. Efficacy of amodiaquine and sulfadoxine/pyrimethamine in the treatment of malaria not complicated by Plasmodium falciparum in Narino, Colombia, 1999-2002. Biomedica (Bogota) 23: 38-46.
15. Blair SLL, Carmona-Fonseca J, Piñeros J, Ríos A, Alvarez T, Alvarez G, Tobón A, 2006. Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia. Malar J 5: 14.
16. Gonzalez IJ, Varela RE, Murillo C, Ferro BE, Salas J. Giraldo LE, Zalis MG, Saravia NG, 2003. Polymorphisms in cg2 and pfcrt genes and resistance to chloroquine and other antimalarials in vitro in Plasmodium falciparum isolates from Colombia. Trans R Soc Trop Med Hyg 97: 318-324.
17. Cortese JF, Caraballo A, Contreras CE, Plowe CV, 2002. Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America. J Infect Dis 186: 999-1006.
18. Sidhu AB, Verdier-Pinard D, Fidock DA, 2002. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298: 210-213.
19. Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA, 2001. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proc Natl Acad Sci USA 98: 12689-12694.
20. Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA, 1996. The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties. Biochem Pharmacol 52: 723-733.
21. Cerutti Junior C, Marques C, Alencar FE, Durlacher RR, Alween A, Segurado AA, Pang LW, Zalis MG, 1999. Antimalarial drug susceptibility testing of Plasmodium falciparum in Brazil using a radioisotope method. Mem Inst Oswaldo Cruz 94: 803-809.
22. Trager W, Jensen JB, 1976. Human malaria parasites in continuous culture. Science 193: 673-675.
23. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD, 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 16: 710-718.
24. Lambros C, Vanderberg JP, 1979. Synchronization of Plasmo dium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420.
25. Noedl H, Bronnert J, Yingyuen K, Attlmayr B, Kollaritsch H, Fukuda M, 2005. Simple histidine-rich protein 2 double-site sandwich enzyme-linked immunosorbent assay for use in malaria drug sensitivity testing. Antimicrob Agents Chemother 49: 3575-3577.
26. Ursing J, Zakeri S, Gil JP, Bjorkman A, 2006. Quinoline resistance associated polymorphisms in the pfcrt, pfmdr1 and pfmrp genes of Plasmodium falciparum in Iran. Acta Trop 97: 352-356.
27. Price RN, Uhlemann AC, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K, Looareesuwan S, White NJ, Nosten F, Krishna S, 2004. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 364: 438-447.
28. Vieira PP, Ferreira MU, Alecrim MG, Alecrim WD, da Silva LH, Sihuincha MM, Joy DA, Mu J, Su XZ, Zalis MG, 2004. pfcrt polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin J Infect Dis 190: 417-424.
29. Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su XZ, 2002. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature 418: 320-323.
30. Warhurst DC, 2003. Polymorphism in the Plasmodium falci purum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine. Malar J 2: 31.
31. Durrand V, Berry A, Sem R, Glaziou P, Beaudou J, Fandeur T, 2004. Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. Mol Biochem Parasitol 136: 273-285.