-
1
-
-
0033614446
-
Chronic myeloid leukemia
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999; 340: 1330-40.
-
(1999)
N Engl J Med
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
2
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
3
-
-
0141528828
-
Chronic myeloid leukemia-advances in biology and new approaches to treatment
-
Goldman JM, Melo JV. Chronic myeloid leukemia-advances in biology and new approaches to treatment. N Engl J Med 2003; 349: 1451-64.
-
(2003)
N Engl J Med
, vol.349
, pp. 1451-1464
-
-
Goldman, J.M.1
Melo, J.V.2
-
4
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001; 344: 1038-42.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
5
-
-
0037105560
-
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
-
Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002; 100: 1965-71.
-
(2002)
Blood
, vol.100
, pp. 1965-1971
-
-
Ottmann, O.G.1
Druker, B.J.2
Sawyers, C.L.3
-
6
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-80.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
7
-
-
0034684075
-
Role of alpha1 acid glycoprotein in the in vivo resistance of human BCRABL(+) leukemic cells to the abl inhibitor STI571
-
Gambacorti-Passerini C, Barni R, Le Coutre P, et al. Role of alpha1 acid glycoprotein in the in vivo resistance of human BCRABL(+) leukemic cells to the abl inhibitor STI571. J Natl Cancer Inst 2000; 92: 1641-50.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1641-1650
-
-
Gambacorti-Passerini, C.1
Barni, R.2
Le Coutre, P.3
-
8
-
-
0037130294
-
Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
-
Hegedus T, Orfi L, Seprodi A, et al. Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochim Biophys Acta 2002; 1587: 318-25.
-
(2002)
Biochim Biophys Acta
, vol.1587
, pp. 318-325
-
-
Hegedus, T.1
Orfi, L.2
Seprodi, A.3
-
9
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003; 101: 690-8.
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
10
-
-
4344672552
-
Imatinib therapy in chronic myelogenous leukemia:Strategies to avoid and overcome resistance
-
Hochhaus A, La Rosse P. Imatinib therapy in chronic myelogenous leukemia:strategies to avoid and overcome resistance. Leukemia 2004; 18: 1321-31.
-
(2004)
Leukemia
, vol.18
, pp. 1321-1331
-
-
Hochhaus, A.1
La Rosse, P.2
-
11
-
-
11144354274
-
High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosomepositive chronic phase chronic myeloid leukemia
-
Kantarjian H, Talpaz M, O'Brien S, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosomepositive chronic phase chronic myeloid leukemia. Blood 2004; 103: 2873-78.
-
(2004)
Blood
, vol.103
, pp. 2873-2878
-
-
Kantarjian, H.1
Talpaz, M.2
O'Brien, S.3
-
12
-
-
0141790853
-
+ leukemia activity of imatinib mesylate
-
+ leukemia activity of imatinib mesylate. Blood 2003; 102:2229-35.
-
(2003)
Blood
, vol.102
, pp. 2229-2235
-
-
Kuroda, J.1
Kimura, S.2
Segawa, H.3
-
13
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
-
14
-
-
4644368478
-
Inhibition of wildtype and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: Implications for CML
-
O'Hara T, Pollock R, Stoffregen EP, et al. Inhibition of wildtype and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood 2004; 104: 2532-39.
-
(2004)
Blood
, vol.104
, pp. 2532-2539
-
-
O'Hara, T.1
Pollock, R.2
Stoffregen, E.P.3
-
15
-
-
18544366598
-
PD166326, a novel tyrosine kinase inhibitor, has greater anti-leukemic activity than imatinib in a murine model of chronic myeloid leukemia
-
Wolff NC, Veach DR, Tong WP, et al. PD166326, a novel tyrosine kinase inhibitor, has greater anti-leukemic activity than imatinib in a murine model of chronic myeloid leukemia. Blood 2005; 105: 3995-4003.
-
(2005)
Blood
, vol.105
, pp. 3995-4003
-
-
Wolff, N.C.1
Veach, D.R.2
Tong, W.P.3
-
16
-
-
0037439689
-
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
-
Golas JM, Arndt K, Etienne D, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res 2003; 3: 375-81.
-
(2003)
Cancer Res
, vol.3
, pp. 375-381
-
-
Golas, J.M.1
Arndt, K.2
Etienne, D.3
-
17
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005, 7:129-41.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
18
-
-
28444479480
-
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
-
Kimura S, Naito H, Segawa H, et al. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood 2005; 106: 3948-54.
-
(2005)
Blood
, vol.106
, pp. 3948-3954
-
-
Kimura, S.1
Naito, H.2
Segawa, H.3
-
19
-
-
13844261144
-
A non-ATPcompetitive inhibitor of BCR-ABL overrides imatinib resistance
-
Gumireddy K, Baker SJ, Cosenza SC, et al. A non-ATPcompetitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci USA 2005; 102: 1992-97.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1992-1997
-
-
Gumireddy, K.1
Baker, S.J.2
Cosenza, S.C.3
-
20
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington EA, Bebbington D, Moore J, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med. 2004; 10: 262-267.
-
(2004)
Nat Med
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
Bebbington, D.2
Moore, J.3
-
21
-
-
23344440655
-
Inhibition of drugresistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drugresistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA 2005; 102:11011-16.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
-
22
-
-
33745102555
-
Dasatinib in imatinibresistant Philadelphia chromosome-positive leukemias
-
Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinibresistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354:2531-41.
-
(2006)
N Engl J Med
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
23
-
-
33644515212
-
A phase II study of dasatinib in patients with accelerated phase chronic myeloid leukemia (CML) who are resistant or intolerant to imatinib: First results of the CA 180005 'START-A' study
-
Guihot F, Apperley JF, Shah N, et al. A phase II study of dasatinib in patients with accelerated phase chronic myeloid leukemia (CML) who are resistant or intolerant to imatinib: first results of the CA 180005 'START-A' study. Blood 2005; 106: 16a.
-
(2005)
Blood
, vol.106
-
-
Guihot, F.1
Apperley, J.F.2
Shah, N.3
-
24
-
-
33644515212
-
A phase II study of dasatinib in patients with chronic myeloid leukemia(CML) in myeloid blast crisis who are resistant or intolerant to imatinib: First results of the CA 180006 'START-B' study
-
Talpaz M, Tousselot P, Kim DW, et al. A phase II study of dasatinib in patients with chronic myeloid leukemia(CML) in myeloid blast crisis who are resistant or intolerant to imatinib: first results of the CA 180006 'START-B' study. Blood 2005; 106: 16a.
-
(2005)
Blood
, vol.106
-
-
Talpaz, M.1
Tousselot, P.2
Kim, D.W.3
-
25
-
-
33644526143
-
Efficacy of dasatinib in patients with chronic phase Philadelphia chromosome-positive CML resistant or intolerant to imatinib: First results of the CA 180013 'START-C' phase II study
-
Hochhaus A, Baccarani M, Sawyers C, et al. Efficacy of dasatinib in patients with chronic phase Philadelphia chromosome-positive CML resistant or intolerant to imatinib: first results of the CA 180013 'START-C' phase II study. Blood 2005; 106: 17a.
-
(2005)
Blood
, vol.106
-
-
Hochhaus, A.1
Baccarani, M.2
Sawyers, C.3
-
26
-
-
33644500644
-
+ ALL) who are resistant or intolerant to imatinib: First results of the CA 180015 'START-L' study
-
+ ALL) who are resistant or intolerant to imatinib: first results of the CA 180015 'START-L' study. Blood. 2005; 106: 17a.
-
(2005)
Blood
, vol.106
-
-
Ottmann, O.G.1
Martinelli, G.2
Dombret, H.3
-
27
-
-
33745086350
-
Nilotinib in imatinibresistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinibresistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006; 354: 2542-51.
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
29
-
-
84873573424
-
In vivo Inhibitory effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on the proliferation of leukemic cells harbouring Abl kinase domain mutations
-
in press
-
Naito H, Kimura S, Nakaya Y, et al. in vivo Inhibitory effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on the proliferation of leukemic cells harbouring Abl kinase domain mutations. Leuk Res, in press.
-
Leuk Res
-
-
Naito, H.1
Kimura, S.2
Nakaya, Y.3
-
30
-
-
84873608292
-
+ leukemia cells in the central nervous system and cyclosporine A augments its in vivo activity
-
in press
-
+ leukemia cells in the central nervous system and cyclosporine A augments its in vivo activity. Blood, in press.
-
Blood
-
-
Yokota, A.1
Kimura, S.2
Masuda, S.3
-
31
-
-
31644438945
-
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680
-
Young MA, Shah NP, Chao LH, et al. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res 2006; 66: 1007-14.
-
(2006)
Cancer Res
, vol.66
, pp. 1007-1014
-
-
Young, M.A.1
Shah, N.P.2
Chao, L.H.3
-
32
-
-
33646848442
-
BIRB-796 is not an effective ABL(T315I) inhibitor
-
O'Hare T, Druker BJ. BIRB-796 is not an effective ABL(T315I) inhibitor. Nat Biotechnol 2005; 23: 329-36.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
O'Hare, T.1
Druker, B.J.2
-
33
-
-
33644508229
-
TM fragment-based lead discovery and structure-guided design to discovery of small molecule inhibitors of BCR-ABL tyrosine kinase active against the T315I imatinib-resistant mutant
-
TM fragment-based lead discovery and structure-guided design to discovery of small molecule inhibitors of BCR-ABL tyrosine kinase active against the T315I imatinib-resistant mutant. Blood 2005; 106: 206a.
-
(2005)
Blood
, vol.106
-
-
Burley, S.K.1
-
34
-
-
84873584955
-
-
WO2006015123A1
-
Arnold, D.W., Bounaud, P., Gosberg, A., Li, Z., Macdonald, I., Steensma, R.W., Wilson, M.E.: WO2006015123A1 (2006).
-
(2006)
-
-
Arnold, D.W.1
Bounaud, P.2
Gosberg, A.3
Li, Z.4
Macdonald, I.5
Steensma, R.W.6
Wilson, M.E.7
-
36
-
-
84873576316
-
-
WO2005115992A1
-
Housey, G.M.: WO2005115992A1 (2005).
-
(2005)
-
-
Housey, G.M.1
-
37
-
-
21744462100
-
Dynamics of chronic myeloid leukemia
-
Michor F, Hughes TP, Iwasa Y, et al. Dynamics of chronic myeloid leukemia. Nature 2005; 435: 1267-70.
-
(2005)
Nature
, vol.435
, pp. 1267-1270
-
-
Michor, F.1
Hughes, T.P.2
Iwasa, Y.3
-
38
-
-
22144443475
-
Drug resistance in cancer: Principles of emergence and prevention
-
Komarova NL, Wodarz D. Drug resistance in cancer: principles of emergence and prevention. Proc Natl Acad Sci USA 2005; 102: 9714-9.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9714-9719
-
-
Komarova, N.L.1
Wodarz, D.2
|