Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations

Annals of Medicine

Volumn 36, Issue 8, 2004, Pages 618-622

  Vasankari, Tommi ^a,b,c   Ahotupa, Markku ^c   Viikari, Jorma ^d   Nuotio, Ilpo ^d   Strandberg, Timo ^e   Vanhanen, Hannu ^e   Gylling, Helena ^e   Miettinen, Tatu ^e   Tikkanen, Matti J ^e  

^a Sports Medical Research Unit   (Finland)

^b Sport Institute of Finland   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Antioxidant potential of LDL; Carotene; Serum antioxidants; Statins; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; ATORVASTATIN; BETA CAROTENE; GAMMA TOCOPHEROL; LOW DENSITY LIPOPROTEIN; SIMVASTATIN; STATIN; VITAMIN;

ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFECT; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPID SOLUBILITY; MALE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ALPHA-TOCOPHEROL; BETA CAROTENE; CHOLESTEROL, LDL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GAMMA-TOCOPHEROL; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PYRROLES; SIMVASTATIN;

EID: 11144227640     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.1080/07853890410018844     Document Type: Article

References (10)

1. Leonhardt W, Kurktschiev T, Meissner D, Lattke P, Abletshauser C, Weidinger G, et al. Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals. Eur J Clin Pharmacol 1997;53:65-9.
2. Jula A, Marniemi J, Huupponen R, Virtanen A, Rastas M, Rönnemaa T. Effects of diet and siravastatin on serum lipids, insulin, and antioxidants in hypercholesterolaemic men: a randomised controlled trial. JAMA 2002;287:598-605.
3. Olsson AG, Eriksson M, Johnson O, Kjellström T, Lanke J, Larsen ML, et al, on behalf of the 3T study investigators. A 52-week, multicenter, randomized, parallel-group, double-blind, double-dummy study to assess the efficacy of atorvastatin and simvastatin in reaching low-density lipoprotein cholesterol and triglyceride targets: The Treat-to-Target (3T) Study. Clin Therap 2003;25:119-38.
4. Milne DB, Bottnen J. Retinol, α-tocopherol, lycopene, and α- and β-carotene simultaneously determined in plasma by isocratic liquid chromatography. Clin Chem 1986;32:874-6.
5. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein concentration in plasma, without use of preparative ultracentrifuge. Clin Chem 1972;18:499-502.
6. Ahotupa M, Ruutu M, Mäntylä E. Simple methods for quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin Biochem 1996;29:139-44.
7. Laaksonen R, Jokelainen K, Laakso J, Sahi T, Härkönen M, Tikkanen MJ, et al. Effects of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am J Cardiol 1996;77:851-4.
8. Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad Biol Med 1992;13:341-90.
9. Bredie SJH, de Bruin TWA, Demacker PNM, Kastelein JJP, Stalenhoef AFH. Comparison of gemfibrozil versus simvastatin in familial combined hyperlipidemia and effects on apolipoprotein-B-containing lipoproteins, low-density lipoprotein subfraction profile, and low-density lipoprotein oxdizability. Am J Cardiol 1995;75:348-53.
10. Behrens WA, Thompson JN, Madere R. Distribution of alpha-tocopherol in human plasma lipoproteins. Am J Clin Nutr 1982;35:691-6.