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Volumn 8, Issue 1, 2008, Pages 5-15

Rationale for anti-CD200 immunotherapy in B-CLL and other hematologic malignancies: New concepts in blocking immune suppression

Author keywords

Cancer; CD200; Immune evasion; Immunosuppression; Leukemia; Monoclonal antibodies

Indexed keywords

ALEMTUZUMAB; ALXN 6000; ANTIBODY; CANCER VACCINE; CD200 ANTIBODY; CD200 ANTIGEN; CELL ANTIBODY; CYCLOPHOSPHAMIDE; CYTOKINE; FLUDARABINE; HLA ANTIGEN CLASS 1; RITUXIMAB; TUMOR ANTIGEN; UNCLASSIFIED DRUG; ANTIGENS, CD200; LEUKOCYTE ANTIGEN;

EID: 38949208028     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.8.1.5     Document Type: Review
Times cited : (37)

References (85)
  • 1
    • 32244442244 scopus 로고    scopus 로고
    • Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation
    • McWhirter JR, Kretz-Rommel A, Saven A, et al. Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation. Proc Natl Acad Sci USA 2006;103:1041-6
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1041-1046
    • McWhirter, J.R.1    Kretz-Rommel, A.2    Saven, A.3
  • 2
    • 33845510301 scopus 로고    scopus 로고
    • CD200 is a new prognostic factor in multiple myeloma
    • Moreaux J, Hose D, Reme T, et al. CD200 is a new prognostic factor in multiple myeloma. Blood 2006;108:4194-7
    • (2006) Blood , vol.108 , pp. 4194-4197
    • Moreaux, J.1    Hose, D.2    Reme, T.3
  • 3
    • 33847175932 scopus 로고    scopus 로고
    • CD200 as a prognostic factor in acute myeloid leukaemia
    • Tonks A, Hills R, White P, et al. CD200 as a prognostic factor in acute myeloid leukaemia. Leukemia 2007;21:566-8
    • (2007) Leukemia , vol.21 , pp. 566-568
    • Tonks, A.1    Hills, R.2    White, P.3
  • 5
    • 0030272856 scopus 로고    scopus 로고
    • Human tumor antigens recognized by T cells
    • Robbins PF, Kawakami Y. Human tumor antigens recognized by T cells. Curr Opin Immunol 1996;8:628-36
    • (1996) Curr Opin Immunol , vol.8 , pp. 628-636
    • Robbins, P.F.1    Kawakami, Y.2
  • 6
    • 34447136106 scopus 로고    scopus 로고
    • Cancer vaccines: Moving beyond current paradigms
    • Schlom J, Arlen PM, Gulley JL. Cancer vaccines: moving beyond current paradigms. Clin Cancer Res 2007;13:3776-82
    • (2007) Clin Cancer Res , vol.13 , pp. 3776-3782
    • Schlom, J.1    Arlen, P.M.2    Gulley, J.L.3
  • 7
    • 34248194231 scopus 로고    scopus 로고
    • Tregs and rethinking cancer immunotherapy
    • Curiel TJ. Tregs and rethinking cancer immunotherapy. J Clin Invest 2007;117:1167-74
    • (2007) J Clin Invest , vol.117 , pp. 1167-1174
    • Curiel, T.J.1
  • 9
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A Phase I/II study
    • Maker AV, Phan GQ, Artia P, et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a Phase I/II study. Ann Surg Oncol 2005;12:1005-16
    • (2005) Ann Surg Oncol , vol.12 , pp. 1005-1016
    • Maker, A.V.1    Phan, G.Q.2    Artia, P.3
  • 10
    • 0020446606 scopus 로고
    • Purification and chemical characterisation of membrane glycoproteins from rat thymocytes and brain, recognised by monoclonal antibody MRC OX 2
    • Barclay AN, Ward HA. Purification and chemical characterisation of membrane glycoproteins from rat thymocytes and brain, recognised by monoclonal antibody MRC OX 2. Eur J Biochem 1982;129:447-58
    • (1982) Eur J Biochem , vol.129 , pp. 447-458
    • Barclay, A.N.1    Ward, H.A.2
  • 11
    • 0035103077 scopus 로고    scopus 로고
    • The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans
    • Wright GJ, Jones M, Puklavec MJ, Brown MH, Barclay AN. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Immunology 2001;102:173-9
    • (2001) Immunology , vol.102 , pp. 173-179
    • Wright, G.J.1    Jones, M.2    Puklavec, M.J.3    Brown, M.H.4    Barclay, A.N.5
  • 12
    • 0021951710 scopus 로고
    • MRC OX-2 antigen: A lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain
    • Clark MJ, Gagnon J, Williams AF, Barclay AN. MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain. EMBO J 1985;4:113-18
    • (1985) EMBO J , vol.4 , pp. 113-118
    • Clark, M.J.1    Gagnon, J.2    Williams, A.F.3    Barclay, A.N.4
  • 13
    • 0022850589 scopus 로고
    • Neuronal/lymphoid membrane glycoprotein MRC OX-2 is a member of the immunoglobulin superfamily with a light-chain-like structure
    • Barclay AN, Clark MJ, Mccaughan GW. Neuronal/lymphoid membrane glycoprotein MRC OX-2 is a member of the immunoglobulin superfamily with a light-chain-like structure. Biochem Soc Symp 1986;51:149-57
    • (1986) Biochem Soc Symp , vol.51 , pp. 149-157
    • Barclay, A.N.1    Clark, M.J.2    Mccaughan, G.W.3
  • 14
    • 0036606950 scopus 로고    scopus 로고
    • CD200 and membrane protein interactions in the control of myeloid cells
    • Barclay AN, Wright GJ, Brooke G, Brown MH. CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol 2002;23:285-90
    • (2002) Trends Immunol , vol.23 , pp. 285-290
    • Barclay, A.N.1    Wright, G.J.2    Brooke, G.3    Brown, M.H.4
  • 15
    • 17744388105 scopus 로고    scopus 로고
    • Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    • Hoek RM, Ruuls SR, Murphy CA, et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000;290:1768-71
    • (2000) Science , vol.290 , pp. 1768-1771
    • Hoek, R.M.1    Ruuls, S.R.2    Murphy, C.A.3
  • 16
    • 0036841128 scopus 로고    scopus 로고
    • Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis
    • Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002;161:1669-77
    • (2002) Am J Pathol , vol.161 , pp. 1669-1677
    • Broderick, C.1    Hoek, R.M.2    Forrester, J.V.3    Liversidge, J.4    Sedgwick, J.D.5    Dick, A.D.6
  • 17
    • 6344225337 scopus 로고    scopus 로고
    • Expression of CD200 on epithelial cells of the murine hair follicle: A role in tissue-specific immune tolerance?
    • Rosenblum MD, Olasz EB, Yancey KB, et al. Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? J Invest Dermatol 2004;123:880-7
    • (2004) J Invest Dermatol , vol.123 , pp. 880-887
    • Rosenblum, M.D.1    Olasz, E.B.2    Yancey, K.B.3
  • 18
    • 0035206952 scopus 로고    scopus 로고
    • CD200 immunoadhesin suppresses collagen-induced arthritis in mice
    • Gorczynski RM, Chen Z, Yu K, Hu J. CD200 immunoadhesin suppresses collagen-induced arthritis in mice. Clin Immunol 2001;101:328-34
    • (2001) Clin Immunol , vol.101 , pp. 328-334
    • Gorczynski, R.M.1    Chen, Z.2    Yu, K.3    Hu, J.4
  • 19
    • 0034922595 scopus 로고    scopus 로고
    • Clark DA, Yu G, Levy GA, Gorczynski RM. Procoagulants in fetus rejection: the role of the OX-2 (CD200) tolerance signal. Semin Immunol 2001;13:255-63
    • Clark DA, Yu G, Levy GA, Gorczynski RM. Procoagulants in fetus rejection: the role of the OX-2 (CD200) tolerance signal. Semin Immunol 2001;13:255-63
  • 20
    • 0038972116 scopus 로고    scopus 로고
    • Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth
    • Gorczynski RM. Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth. Arch Immunol Ther Exp (Warsz) 2001;49:303-9
    • (2001) Arch Immunol Ther Exp (Warsz) , vol.49 , pp. 303-309
    • Gorczynski, R.M.1
  • 21
    • 0036750535 scopus 로고    scopus 로고
    • Anti-CD20OR ameliorates collagen-induced arthritis in mice
    • Gorczynski RM, Chen Z, Lee L, Yu K, Hu J. Anti-CD20OR ameliorates collagen-induced arthritis in mice. Clin Immunol 2002;104:256-64
    • (2002) Clin Immunol , vol.104 , pp. 256-264
    • Gorczynski, R.M.1    Chen, Z.2    Lee, L.3    Yu, K.4    Hu, J.5
  • 22
    • 34548306817 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis
    • Copland DA, Calder CJ, Raveney BJ, et al. Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. Am J Pathol 2007;171:580-8
    • (2007) Am J Pathol , vol.171 , pp. 580-588
    • Copland, D.A.1    Calder, C.J.2    Raveney, B.J.3
  • 23
    • 3142748419 scopus 로고    scopus 로고
    • Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor
    • Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN. Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. J Virol 2004;78:7667-76
    • (2004) J Virol , vol.78 , pp. 7667-7676
    • Foster-Cuevas, M.1    Wright, G.J.2    Puklavec, M.J.3    Brown, M.H.4    Barclay, A.N.5
  • 24
    • 17444429652 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 replication and transcription activator regulates viral and cellular genes via interferon-stimulated response elements
    • Zhang J, Wang J, Wood C, Xu D, Zhang L. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 replication and transcription activator regulates viral and cellular genes via interferon-stimulated response elements. J Virol 2005;79:5640-52
    • (2005) J Virol , vol.79 , pp. 5640-5652
    • Zhang, J.1    Wang, J.2    Wood, C.3    Xu, D.4    Zhang, L.5
  • 25
    • 25444446577 scopus 로고    scopus 로고
    • Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200
    • Shiratori I, Yamaguchi M, Suzukawa M, et al. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J Immunol 2005;175:4441-9
    • (2005) J Immunol , vol.175 , pp. 4441-4449
    • Shiratori, I.1    Yamaguchi, M.2    Suzukawa, M.3
  • 26
    • 18144393023 scopus 로고    scopus 로고
    • Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo
    • Cameron CM, Barrett JW, Liu L, Lucas AR, McFadden G. Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo J Virol 2005;79:6052-67
    • (2005) J Virol , vol.79 , pp. 6052-6067
    • Cameron, C.M.1    Barrett, J.W.2    Liu, L.3    Lucas, A.R.4    McFadden, G.5
  • 27
    • 13644281397 scopus 로고    scopus 로고
    • The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: Further evidence for a separate evolutionary lineage from that of rat CMV Maastricht
    • Voigt S, Sandford GR, Hayward GS, Burns WH. The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht. J Gen Virol 2005;86:263-74
    • (2005) J Gen Virol , vol.86 , pp. 263-274
    • Voigt, S.1    Sandford, G.R.2    Hayward, G.S.3    Burns, W.H.4
  • 28
    • 33644768071 scopus 로고    scopus 로고
    • Rhesus rhadinovirus R15 encodes a functional homologue of human CD200
    • Langlais CL, Jones JM, Estep RD, Wong SW. Rhesus rhadinovirus R15 encodes a functional homologue of human CD200. J Virol 2006;80:3098-103
    • (2006) J Virol , vol.80 , pp. 3098-3103
    • Langlais, C.L.1    Jones, J.M.2    Estep, R.D.3    Wong, S.W.4
  • 29
    • 0033178938 scopus 로고    scopus 로고
    • An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival
    • Gorczynski RM, Cattral MS, Chen Z, et al. An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival. J Immunol 1999;163:1654-60
    • (1999) J Immunol , vol.163 , pp. 1654-1660
    • Gorczynski, R.M.1    Cattral, M.S.2    Chen, Z.3
  • 30
    • 0033151545 scopus 로고    scopus 로고
    • Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX-2
    • Ragheb R, Abrahams S, Beecroft R, et al. Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX-2. Immunol Lett 1999;68:311-15
    • (1999) Immunol Lett , vol.68 , pp. 311-315
    • Ragheb, R.1    Abrahams, S.2    Beecroft, R.3
  • 31
    • 2342479819 scopus 로고    scopus 로고
    • Induction of tolerance-inducing antigen-presenting cells in bone marrow cultures in vitro using monoclonal antibodies to CD200R
    • Gorczynski RM, Chen Z, Kai Y, Wong S, Lee L. Induction of tolerance-inducing antigen-presenting cells in bone marrow cultures in vitro using monoclonal antibodies to CD200R. Transplantation 2004;77:1138-44
    • (2004) Transplantation , vol.77 , pp. 1138-1144
    • Gorczynski, R.M.1    Chen, Z.2    Kai, Y.3    Wong, S.4    Lee, L.5
  • 32
    • 4644220112 scopus 로고    scopus 로고
    • Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement
    • Fallarino F, Sselin-Paturel C, Vacca C, et al. Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement. J Immunol 2004;173:3748-54
    • (2004) J Immunol , vol.173 , pp. 3748-3754
    • Fallarino, F.1    Sselin-Paturel, C.2    Vacca, C.3
  • 34
    • 9144224962 scopus 로고    scopus 로고
    • Molecular mechanisms of CD200 inhibition of mast cell activation
    • Zhang S, Cherwinski H, Sedgwick JD, Phillips JH. Molecular mechanisms of CD200 inhibition of mast cell activation. J Immunol 2004;173:6786-93
    • (2004) J Immunol , vol.173 , pp. 6786-6793
    • Zhang, S.1    Cherwinski, H.2    Sedgwick, J.D.3    Phillips, J.H.4
  • 35
    • 19944431055 scopus 로고    scopus 로고
    • The CD200 receptor is a novel and potent regulator of murine and human mast cell function
    • Cherwinski HM, Murphy CA, Joyce BL, et al. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. J Immunol 2005;174:1348-56
    • (2005) J Immunol , vol.174 , pp. 1348-1356
    • Cherwinski, H.M.1    Murphy, C.A.2    Joyce, B.L.3
  • 37
    • 39049118197 scopus 로고    scopus 로고
    • Immune evasion by melanoma and ovarian tumor cells through upregulation of the immunosuppressive molecule CD200
    • Edition
    • Siva A, Xin H, Qin F, et al. Immune evasion by melanoma and ovarian tumor cells through upregulation of the immunosuppressive molecule CD200. J Clin Oncol 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition) 2006;24(18S):2545
    • (2006) J Clin Oncol 2006 ASCO Annual Meeting Proceedings (Post-Meeting , vol.24 , Issue.18 S , pp. 2545
    • Siva, A.1    Xin, H.2    Qin, F.3
  • 38
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:793-800
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 39
    • 33645853780 scopus 로고    scopus 로고
    • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • Kryczek I, Zou L, Rodriguez P, et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 2006;203:871-81
    • (2006) J Exp Med , vol.203 , pp. 871-881
    • Kryczek, I.1    Zou, L.2    Rodriguez, P.3
  • 40
    • 39049111799 scopus 로고    scopus 로고
    • html SEER Stat Fact Sheet on Chronic Lymphocytic Leukaemia Available at: URL: http://seer.cancer.gov/statfacts/html/clyl [last accessed November 2007]
    • html SEER Stat Fact Sheet on Chronic Lymphocytic Leukaemia Available at: URL: http://seer.cancer.gov/statfacts/html/clyl [last accessed November 2007]
  • 41
    • 4344568293 scopus 로고    scopus 로고
    • Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia
    • vii
    • Carovsky D. Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2004;18:783-94, vii
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 783-794
    • Carovsky, D.1
  • 42
  • 43
    • 0036624880 scopus 로고    scopus 로고
    • Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocydc leukemia
    • Mertens D, Wolf S, Schroeter P, et al. Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocydc leukemia. Blood 2002;99:4116-21
    • (2002) Blood , vol.99 , pp. 4116-4121
    • Mertens, D.1    Wolf, S.2    Schroeter, P.3
  • 44
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000;343:1910-16
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 45
    • 0037081762 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia with a novel der(8;15)(q10;q10) translocation
    • Wong KF, So CC. Chronic lymphocytic leukemia with a novel der(8;15)(q10;q10) translocation. Cancer Genet Cytogenet 2002;132:159-60
    • (2002) Cancer Genet Cytogenet , vol.132 , pp. 159-160
    • Wong, K.F.1    So, C.C.2
  • 46
    • 12244289616 scopus 로고    scopus 로고
    • Cytogenetic and molecular delineation of a region of chromosome 3q commonly gained in marginal zone B-cell lymphoma
    • Gazzo S, Baseggio L, Coignet L, et al. Cytogenetic and molecular delineation of a region of chromosome 3q commonly gained in marginal zone B-cell lymphoma. Haematologica 2003;88:31-8
    • (2003) Haematologica , vol.88 , pp. 31-38
    • Gazzo, S.1    Baseggio, L.2    Coignet, L.3
  • 48
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348:1764-75
    • (2003) N Engl J Med , vol.348 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 49
    • 0036839469 scopus 로고    scopus 로고
    • Phase II study of a combined immunochemotherapy using rituximab and fludambine in patients with chronic lymphocytic leukemia
    • Schutz H, Klein SK, Rehwald U, et al. Phase II study of a combined immunochemotherapy using rituximab and fludambine in patients with chronic lymphocytic leukemia. Blood 2002;100:3115-20
    • (2002) Blood , vol.100 , pp. 3115-3120
    • Schutz, H.1    Klein, S.K.2    Rehwald, U.3
  • 50
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 2005;105:49-53
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 51
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 2005;23:4079-88
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 52
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H, Fischer K, Bentz M, et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 1995;85:1580-9
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3
  • 53
    • 0036335916 scopus 로고    scopus 로고
    • Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Kontoyiannis D, et al. Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia. Leuk Lymphoma 2002;43:1755-62
    • (2002) Leuk Lymphoma , vol.43 , pp. 1755-1762
    • Keating, M.J.1    O'Brien, S.2    Kontoyiannis, D.3
  • 54
    • 4344659804 scopus 로고    scopus 로고
    • Role of auto- and allontransplantation in B-cell chronic lymphocytic leukemia
    • x
    • Montserrat E. Role of auto- and allontransplantation in B-cell chronic lymphocytic leukemia. Haematol Oncol Clin North Am 2004;18(4):915-26, x
    • (2004) Haematol Oncol Clin North Am , vol.18 , Issue.4 , pp. 915-926
    • Montserrat, E.1
  • 55
    • 0015449886 scopus 로고
    • In vivo studies of the role of cytotoxic T cells in tumor allograft immunity
    • Freedman LR, Cerottini JC, Brunner KT. In vivo studies of the role of cytotoxic T cells in tumor allograft immunity. J Immunol 1972;109:1371-8
    • (1972) J Immunol , vol.109 , pp. 1371-1378
    • Freedman, L.R.1    Cerottini, J.C.2    Brunner, K.T.3
  • 56
    • 0016639490 scopus 로고
    • Cytotoxic effects of antigen- and mitogen-induced T cells on various targets
    • Bevan MJ, Cohn M. Cytotoxic effects of antigen- and mitogen-induced T cells on various targets. J Immunol 1975;114:559-65
    • (1975) J Immunol , vol.114 , pp. 559-565
    • Bevan, M.J.1    Cohn, M.2
  • 57
    • 26244464685 scopus 로고    scopus 로고
    • Continuous presence of Th1 conditions is necessary for longer lasting tumor-specific CTL activity in stimulation cultures with PBL
    • Chattopadhyay S, Chakraborty NG. Continuous presence of Th1 conditions is necessary for longer lasting tumor-specific CTL activity in stimulation cultures with PBL. Hum Immunol 2005;66:884-91
    • (2005) Hum Immunol , vol.66 , pp. 884-891
    • Chattopadhyay, S.1    Chakraborty, N.G.2
  • 58
    • 0028142482 scopus 로고
    • Abnormal cytokine expression in Sezary and adult T-cell leukemia cells correlates with the functional diversity between these T-cell malignancies
    • Tendler CL, Burton JD, Jaffe J, et al. Abnormal cytokine expression in Sezary and adult T-cell leukemia cells correlates with the functional diversity between these T-cell malignancies. Cancer Res 1994;54:4430-5
    • (1994) Cancer Res , vol.54 , pp. 4430-4435
    • Tendler, C.L.1    Burton, J.D.2    Jaffe, J.3
  • 59
    • 0031054772 scopus 로고    scopus 로고
    • Th2-like response and antitumor effect of anti-interleukin-4 mAb in mice bearing renal cell carcinoma
    • Takeuchi T, Ueki T, Sasaki Y, et al. Th2-like response and antitumor effect of anti-interleukin-4 mAb in mice bearing renal cell carcinoma. Cancer Immunol Immunother 1997;43:375-81
    • (1997) Cancer Immunol Immunother , vol.43 , pp. 375-381
    • Takeuchi, T.1    Ueki, T.2    Sasaki, Y.3
  • 61
    • 0036305649 scopus 로고    scopus 로고
    • Malignant melanoma associates with Th1/Th2 imbalance that coincides with disease progression and immunotherapy response
    • Lauerova L, Dusek L, Simickova M, et al. Malignant melanoma associates with Th1/Th2 imbalance that coincides with disease progression and immunotherapy response. Neoplasma 2002;49:159-66
    • (2002) Neoplasma , vol.49 , pp. 159-166
    • Lauerova, L.1    Dusek, L.2    Simickova, M.3
  • 62
    • 0032949372 scopus 로고    scopus 로고
    • Th2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers
    • Tabata T, Hazama S, Yoshino S, Oka M. Th2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers. Am J Surg 1999;177:203-8
    • (1999) Am J Surg , vol.177 , pp. 203-208
    • Tabata, T.1    Hazama, S.2    Yoshino, S.3    Oka, M.4
  • 63
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a Phase I trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a Phase I trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006;355:1018-28
    • (2006) N Engl J Med , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 64
    • 40449088359 scopus 로고    scopus 로고
    • Blockade of CD200 in the presence or absence of antibody effector function: Implications for anti-CD200 therapy
    • In Press
    • Kretz-Rommel A, Qin F, Dakappagari N, et al. Blockade of CD200 in the presence or absence of antibody effector function: implications for anti-CD200 therapy. J Immunol (In Press)
    • J Immunol
    • Kretz-Rommel, A.1    Qin, F.2    Dakappagari, N.3
  • 65
    • 34247639475 scopus 로고    scopus 로고
    • CD200 expression on tumor cells suppresses antitumor immunity: New approaches to cancer immunotherapy
    • Kretz-Rommel A, Qin F, Dakappagari N, et al. CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy. J Immunol 2007;178:5595-605
    • (2007) J Immunol , vol.178 , pp. 5595-5605
    • Kretz-Rommel, A.1    Qin, F.2    Dakappagari, N.3
  • 66
    • 0025762394 scopus 로고
    • The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region
    • Canfield SM, Morrison SL. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J Exp Med 1991;173:1483-91
    • (1991) J Exp Med , vol.173 , pp. 1483-1491
    • Canfield, S.M.1    Morrison, S.L.2
  • 67
    • 0027213573 scopus 로고
    • Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation
    • Tao MH, Smith RI, Morrison SL. Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. J Exp Med 1993;178:661-7
    • (1993) J Exp Med , vol.178 , pp. 661-667
    • Tao, M.H.1    Smith, R.I.2    Morrison, S.L.3
  • 68
    • 0030761203 scopus 로고    scopus 로고
    • Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells
    • Mueller JP, Giannoni MA, Hartman SL, et al. Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells. Mol Immunol 1997;34:441-52
    • (1997) Mol Immunol , vol.34 , pp. 441-452
    • Mueller, J.P.1    Giannoni, M.A.2    Hartman, S.L.3
  • 69
    • 10744228553 scopus 로고    scopus 로고
    • Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria
    • Hillmen P, Hall C, Marsh JC, et al. Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 2004;350:552-9
    • (2004) N Engl J Med , vol.350 , pp. 552-559
    • Hillmen, P.1    Hall, C.2    Marsh, J.C.3
  • 70
    • 27144440502 scopus 로고    scopus 로고
    • Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria
    • Hill A, Hillmen P, Richards SJ, et al. Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria. Blood 2005;106:2559-65
    • (2005) Blood , vol.106 , pp. 2559-2565
    • Hill, A.1    Hillmen, P.2    Richards, S.J.3
  • 71
    • 35948962168 scopus 로고    scopus 로고
    • Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria
    • Hillmen P, Muus P, Duhrsen U, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood 2007;110:4123-8
    • (2007) Blood , vol.110 , pp. 4123-4128
    • Hillmen, P.1    Muus, P.2    Duhrsen, U.3
  • 72
    • 4344686812 scopus 로고    scopus 로고
    • Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the fero-maternal interface
    • Gorczynski RM, Chen Z, Clark DA, et al. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the fero-maternal interface. Am J Reprod Immunol 2004;52:147-63
    • (2004) Am J Reprod Immunol , vol.52 , pp. 147-163
    • Gorczynski, R.M.1    Chen, Z.2    Clark, D.A.3
  • 73
    • 0013963675 scopus 로고
    • Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji)
    • Epstein MA, Achong BG, Barr YM, Zajac B, Henle G, Henle W. Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji). J Natl Cancer Inst 1966;37:547-59
    • (1966) J Natl Cancer Inst , vol.37 , pp. 547-559
    • Epstein, M.A.1    Achong, B.G.2    Barr, Y.M.3    Zajac, B.4    Henle, G.5    Henle, W.6
  • 74
    • 0015509615 scopus 로고
    • Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus
    • Klein G, Dombos L, Gothoskar B. Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus. Int J Cancer 1972;10:44-57
    • (1972) Int J Cancer , vol.10 , pp. 44-57
    • Klein, G.1    Dombos, L.2    Gothoskar, B.3
  • 75
    • 11144257840 scopus 로고    scopus 로고
    • GMP production and testing of Xcellerated T Cells for the treatment of patients with CLL
    • Hami LS, Green C, Leshinsky N, Markham E, Miller K Craig S. GMP production and testing of Xcellerated T Cells for the treatment of patients with CLL. Cytotherapy 2004;6:554-62
    • (2004) Cytotherapy , vol.6 , pp. 554-562
    • Hami, L.S.1    Green, C.2    Leshinsky, N.3    Markham, E.4    Miller, K.5    Craig, S.6
  • 76
    • 0034125194 scopus 로고    scopus 로고
    • Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies
    • Trojan A, Schultze JL, Witzens M, et al. Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies. Nat Med 2000;6:667-72
    • (2000) Nat Med , vol.6 , pp. 667-672
    • Trojan, A.1    Schultze, J.L.2    Witzens, M.3
  • 77
    • 0034781930 scopus 로고    scopus 로고
    • Generation in vitro of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate
    • Goddard RV, Prentice AG, Copplestone JA, Kaminski ER. Generation in vitro of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate. Clin Exp Immunol 2001;126:16-28
    • (2001) Clin Exp Immunol , vol.126 , pp. 16-28
    • Goddard, R.V.1    Prentice, A.G.2    Copplestone, J.A.3    Kaminski, E.R.4
  • 78
    • 0037652216 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia-reactive T cells during disease progression and after autologous tumor cell vaccines
    • Gitelson E, Hammond C, Mena J, et al. Chronic lymphocytic leukemia-reactive T cells during disease progression and after autologous tumor cell vaccines. Clin Cancer Res 2003;9:1656-65
    • (2003) Clin Cancer Res , vol.9 , pp. 1656-1665
    • Gitelson, E.1    Hammond, C.2    Mena, J.3
  • 79
    • 0037865501 scopus 로고    scopus 로고
    • Dendritic cell vaccination for patients with chronic myelogenous leukemia
    • Takahashi T, Tanaka Y, Nieda M, et al. Dendritic cell vaccination for patients with chronic myelogenous leukemia. Leuk Res 2003;27:795-802
    • (2003) Leuk Res , vol.27 , pp. 795-802
    • Takahashi, T.1    Tanaka, Y.2    Nieda, M.3
  • 80
    • 0043092221 scopus 로고    scopus 로고
    • The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response
    • Orsini E, Guarini A, Chiaretti S, Mauro FR, Foa R. The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response. Cancer Res 2003;63:4497-506
    • (2003) Cancer Res , vol.63 , pp. 4497-4506
    • Orsini, E.1    Guarini, A.2    Chiaretti, S.3    Mauro, F.R.4    Foa, R.5
  • 81
    • 0031407252 scopus 로고    scopus 로고
    • Autoimmune phenomena and hepatitis C virus in lymphoproliferative and connective tissue disorders
    • Caligaris-Cappio F, De Leo AM, Bertero MT. Autoimmune phenomena and hepatitis C virus in lymphoproliferative and connective tissue disorders. Leuk Lymphoma 1997;28:57-63
    • (1997) Leuk Lymphoma , vol.28 , pp. 57-63
    • Caligaris-Cappio, F.1    De Leo, A.M.2    Bertero, M.T.3
  • 82
    • 33845930550 scopus 로고    scopus 로고
    • Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia
    • Barcellini W, Capalbo S, Agostinelli RM, et al. Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia. Haematologica 2006;91:1689-92
    • (2006) Haematologica , vol.91 , pp. 1689-1692
    • Barcellini, W.1    Capalbo, S.2    Agostinelli, R.M.3
  • 83
    • 0042236333 scopus 로고    scopus 로고
    • Rituximab in B-cell chronic lymphocytic leukemia
    • Lin TS, Lucas MS, Byrd JC. Rituximab in B-cell chronic lymphocytic leukemia. Semin Oncol 2003;30:483-92
    • (2003) Semin Oncol , vol.30 , pp. 483-492
    • Lin, T.S.1    Lucas, M.S.2    Byrd, J.C.3
  • 84
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patient with chronic lymphocytic leukemia after therapy with fludarabine 2
    • Beyer M, Kochanek M, Darabi K, et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patient with chronic lymphocytic leukemia after therapy with fludarabine 2. Blood 2005;106:2018-25
    • (2005) Blood , vol.106 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3
  • 85
    • 33847197174 scopus 로고    scopus 로고
    • Evidence accumulating in support of cancer vaccines combined with chemotherapy: A pragmatic review of past and present efforts
    • Sinkovics JG, Horvath JC. Evidence accumulating in support of cancer vaccines combined with chemotherapy: a pragmatic review of past and present efforts. Int J Oncol 2006;29:765-77
    • (2006) Int J Oncol , vol.29 , pp. 765-777
    • Sinkovics, J.G.1    Horvath, J.C.2


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