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Volumn 34, Issue 6, 1997, Pages 441-452

Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells

Author keywords

Adhesion molecules; Antibodies; Fc receptors; Inflammation; Xenotransplantation

Indexed keywords

BETA1 INTEGRIN; IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

EID: 0030761203     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00042-4     Document Type: Article
Times cited : (37)

References (49)
  • 7
    • 0026657624 scopus 로고
    • Human antibody effector function
    • Burton D. R. and Woof J. M. (1992) Human antibody effector function. Adv. Immun. 51, 1-18.
    • (1992) Adv. Immun. , vol.51 , pp. 1-18
    • Burton, D.R.1    Woof, J.M.2
  • 8
    • 0025762394 scopus 로고
    • The binding affinity of human IgG for its high affinity FcR is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region
    • Canfield S. M. and Morrison S. L. (1991) The binding affinity of human IgG for its high affinity FcR is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. J. Exp. Med. 173, 1483-1491.
    • (1991) J. Exp. Med. , vol.173 , pp. 1483-1491
    • Canfield, S.M.1    Morrison, S.L.2
  • 9
    • 0027935309 scopus 로고
    • Leukocyte-endothelial adhesion molecules
    • Carlos T. M. and Harlan J. M. (1994) Leukocyte-endothelial adhesion molecules. Blood 84, 2068-2101.
    • (1994) Blood , vol.84 , pp. 2068-2101
    • Carlos, T.M.1    Harlan, J.M.2
  • 10
    • 0022213697 scopus 로고
    • T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fcγ receptors for murine IgG2a and inability to cross-link the T3-Ti complex
    • Ceuppens J. L., Bloemmen F. J. and Wauwe J. P. van (1985) T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fcγ receptors for murine IgG2a and inability to cross-link the T3-Ti complex. J. Immun. 135, 3882-3886.
    • (1985) J. Immun. , vol.135 , pp. 3882-3886
    • Ceuppens, J.L.1    Bloemmen, F.J.2    Van Wauwe, J.P.3
  • 11
    • 0027512121 scopus 로고
    • Monoclonal antibodies to the integrin α4 subunit inhibit the murine contact hypersensitivity response
    • Chisholm P. L., Williams C. A. and Lobb R. R. (1993) Monoclonal antibodies to the integrin α4 subunit inhibit the murine contact hypersensitivity response. Eur. J. Immun. 23, 621-628.
    • (1993) Eur. J. Immun. , vol.23 , pp. 621-628
    • Chisholm, P.L.1    Williams, C.A.2    Lobb, R.R.3
  • 12
    • 0029024026 scopus 로고
    • Domains 1 and 4 of vascular cell adhesion molecule-1 (CD106) both support very late activation antigen-4 (CD49d/CD29)-dependent monocyte transendothelial migration
    • Chuluyan H. E., Osborn L., Lobb R. and Issekutz A. C. (1995) Domains 1 and 4 of vascular cell adhesion molecule-1 (CD106) both support very late activation antigen-4 (CD49d/CD29)-dependent monocyte transendothelial migration. J. Immun. 155, 3135-3144
    • (1995) J. Immun. , vol.155 , pp. 3135-3144
    • Chuluyan, H.E.1    Osborn, L.2    Lobb, R.3    Issekutz, A.C.4
  • 14
    • 0023933120 scopus 로고
    • Localization of the binding site for the human high-affinity FcR on IgG
    • Duncan A. R., Woof J. M., Partridge L. J., Burton D. R. and Winter G. (1988) Localization of the binding site for the human high-affinity FcR on IgG. Nature 332, 563-564.
    • (1988) Nature , vol.332 , pp. 563-564
    • Duncan, A.R.1    Woof, J.M.2    Partridge, L.J.3    Burton, D.R.4    Winter, G.5
  • 15
    • 0029063045 scopus 로고
    • Rapid expression of an anti-human C5 chimeric Fab utilizing a vector that replicates in COS and 293 cells
    • Evans M. J., Hartman S. L., Wolff D. W., Rollins S. A. and Squinto S. P. (1995a) Rapid expression of an anti-human C5 chimeric Fab utilizing a vector that replicates in COS and 293 cells. J. Immun. Meth. 184, 123-138.
    • (1995) J. Immun. Meth. , vol.184 , pp. 123-138
    • Evans, M.J.1    Hartman, S.L.2    Wolff, D.W.3    Rollins, S.A.4    Squinto, S.P.5
  • 17
    • 0029256579 scopus 로고
    • Strategies for circumventing transplant rejection: Modification of cells, tissues and organs
    • Faustman D. (1995) Strategies for circumventing transplant rejection: modification of cells, tissues and organs. Trends Biotech. 13, 100-105.
    • (1995) Trends Biotech. , vol.13 , pp. 100-105
    • Faustman, D.1
  • 18
    • 0027942023 scopus 로고
    • Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity
    • Guinan E. C., Gribben J. G., Boussiotis V. A., Freeman G. J. and Nadler L. M. (1994) Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood 84, 3261-3282.
    • (1994) Blood , vol.84 , pp. 3261-3282
    • Guinan, E.C.1    Gribben, J.G.2    Boussiotis, V.A.3    Freeman, G.J.4    Nadler, L.M.5
  • 19
    • 0026520089 scopus 로고
    • Leukocyte adhesion deficiency: Clinical and postmortem observations
    • Hawkins H. K., Heffelfinger S. C. and Anderson D. C. (1992) Leukocyte adhesion deficiency: clinical and postmortem observations. Ped. Pathol. 12, 119-130.
    • (1992) Ped. Pathol. , vol.12 , pp. 119-130
    • Hawkins, H.K.1    Heffelfinger, S.C.2    Anderson, D.C.3
  • 20
    • 0026343689 scopus 로고
    • Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 mAb: A likely role for VLA-4 in vivo
    • Issekutz T. B. (1991) Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 mAb: a likely role for VLA-4 in vivo. J. Immun. 147, 4178-4184.
    • (1991) J. Immun. , vol.147 , pp. 4178-4184
    • Issekutz, T.B.1
  • 21
    • 0026457547 scopus 로고
    • Inhibition of lymphocyte endothelial adhesion and in vivo lymphocyte migration to cutaneous inflammation by TA-3, a new mAb to rat LFA-1
    • Issekutz T. B. (1992) Inhibition of lymphocyte endothelial adhesion and in vivo lymphocyte migration to cutaneous inflammation by TA-3, a new mAb to rat LFA-1. J. Immun. 149, 3394-3402.
    • (1992) J. Immun. , vol.149 , pp. 3394-3402
    • Issekutz, T.B.1
  • 22
    • 0025062267 scopus 로고
    • On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules
    • Johnston S. C., Dustin M. L., Hibbs M. L. and Springer T. A. (1990) On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules. J. Immun. 145, 1181-1187.
    • (1990) J. Immun. , vol.145 , pp. 1181-1187
    • Johnston, S.C.1    Dustin, M.L.2    Hibbs, M.L.3    Springer, T.A.4
  • 24
    • 0022610836 scopus 로고
    • FcRs on monocytes cause OKT3-treated lymphocytes to internalize T3 and to secrete IL-2
    • Kan E. A. R., Wright S. D., Welte K. and Wand C. Y. (1986) FcRs on monocytes cause OKT3-treated lymphocytes to internalize T3 and to secrete IL-2. Cell. Immun. 98, 181-185.
    • (1986) Cell. Immun. , vol.98 , pp. 181-185
    • Kan, E.A.R.1    Wright, S.D.2    Welte, K.3    Wand, C.Y.4
  • 26
    • 0028307575 scopus 로고
    • Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, β1-integrins, and β2-integrins
    • Luscinskas F. W., Kansas G. S., Ding H., Pizcueta P., Schleiffenbaum B. E., Tedder T. F. and Gimbrone M. A. (1994) Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, β1-integrins, and β2-integrins. J. Cell Biol. 125, 1417-1427.
    • (1994) J. Cell Biol. , vol.125 , pp. 1417-1427
    • Luscinskas, F.W.1    Kansas, G.S.2    Ding, H.3    Pizcueta, P.4    Schleiffenbaum, B.E.5    Tedder, T.F.6    Gimbrone, M.A.7
  • 27
    • 0028899113 scopus 로고
    • P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow
    • Luscinskas F. W., Ding H. and Lichtman A. H. (1995) P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow. J. Exp. Med. 181, 1179-1186.
    • (1995) J. Exp. Med. , vol.181 , pp. 1179-1186
    • Luscinskas, F.W.1    Ding, H.2    Lichtman, A.H.3
  • 28
    • 0028294140 scopus 로고
    • Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro
    • Meershaert J. and Furie M. B. (1994) Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro. J. Immun. 152, 1915-1926.
    • (1994) J. Immun. , vol.152 , pp. 1915-1926
    • Meershaert, J.1    Furie, M.B.2
  • 29
    • 0029560747 scopus 로고
    • Porcine vascular cell adhesion molecule (VCAM) mediates endothelial cell adhesion to human T cells
    • Mueller J. P., Evans M. J., Cofiell R., Rother R. P., Matis L. A. and Elliott E. A. (1995) Porcine vascular cell adhesion molecule (VCAM) mediates endothelial cell adhesion to human T cells. Transplantation 60, 1299-1306.
    • (1995) Transplantation , vol.60 , pp. 1299-1306
    • Mueller, J.P.1    Evans, M.J.2    Cofiell, R.3    Rother, R.P.4    Matis, L.A.5    Elliott, E.A.6
  • 30
    • 0028406899 scopus 로고
    • Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28
    • Murray A. G., Khodadoust M. M., Pober J. S. and Bothwell A. L. (1994) Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1, 57-63.
    • (1994) Immunity , vol.1 , pp. 57-63
    • Murray, A.G.1    Khodadoust, M.M.2    Pober, J.S.3    Bothwell, A.L.4
  • 32
    • 0026642672 scopus 로고
    • Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1
    • Osborn L., Vassallo C. and Benjamin C. D. (1992) Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1. J. Exp. Med. 176, 99-107.
    • (1992) J. Exp. Med. , vol.176 , pp. 99-107
    • Osborn, L.1    Vassallo, C.2    Benjamin, C.D.3
  • 34
    • 0028246595 scopus 로고
    • Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to α4β1
    • Renz M. E., Chiu H. H., Jones S., Fox J., Kin K. J., Presta L. G. and Fong S. (1994) Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to α4β1. Cell Biol. 125, 1395-1406.
    • (1994) Cell Biol. , vol.125 , pp. 1395-1406
    • Renz, M.E.1    Chiu, H.H.2    Jones, S.3    Fox, J.4    Kin, K.J.5    Presta, L.G.6    Fong, S.7
  • 36
    • 0028321443 scopus 로고
    • Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2
    • Rollins S. A., Kennedy S. P., Chodera A. J., Elliott E. A., Zavoico G. B. and Matis L. A. (1994b) Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2. Transplantation 57, 1709-1716.
    • (1994) Transplantation , vol.57 , pp. 1709-1716
    • Rollins, S.A.1    Kennedy, S.P.2    Chodera, A.J.3    Elliott, E.A.4    Zavoico, G.B.5    Matis, L.A.6
  • 37
    • 0027294658 scopus 로고
    • Reduced contact sensitivity reactions in mice treated with mAbs to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1
    • Scheynius A., Camp R. L. and Puré E. (1993) Reduced contact sensitivity reactions in mice treated with mAbs to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1. J. Immun. 150, 655-663.
    • (1993) J. Immun. , vol.150 , pp. 655-663
    • Scheynius, A.1    Camp, R.L.2    Puré, E.3
  • 38
    • 0028267295 scopus 로고
    • Recruitment of lymphocytes during cutaneous delayed hypersensitivity in non-human primates is dependent on E-selectin and VCAM-1
    • Silber A., Newman W., Sasseville V. G., Pauley D., Beall D., Walsh D. G. and Ringler D. J. (1995) Recruitment of lymphocytes during cutaneous delayed hypersensitivity in non-human primates is dependent on E-selectin and VCAM-1. J. Clin. Invest. 93, 1554-1563.
    • (1995) J. Clin. Invest. , vol.93 , pp. 1554-1563
    • Silber, A.1    Newman, W.2    Sasseville, V.G.3    Pauley, D.4    Beall, D.5    Walsh, D.G.6    Ringler, D.J.7
  • 39
    • 0028985495 scopus 로고
    • Addition of a μ-tailpiece to IgG results in polymeric antibodies with enhanced effector functions including C-mediated cytolysis by IgG4
    • Smith R. I. F., Coloma M. J. and Morrison S. L. (1995) Addition of a μ-tailpiece to IgG results in polymeric antibodies with enhanced effector functions including C-mediated cytolysis by IgG4. J. Immun. 154, 2226-2236.
    • (1995) J. Immun. , vol.154 , pp. 2226-2236
    • Smith, R.I.F.1    Coloma, M.J.2    Morrison, S.L.3
  • 40
    • 0001642388 scopus 로고
    • Future directions in transplantation: Xenotransplantation
    • Somerville C. A. and D'Apice A. J. F. (1993) Future directions in transplantation: xenotransplantation. Kidney Int. 42, S112.
    • (1993) Kidney Int. , vol.42
    • Somerville, C.A.1    D'Apice, A.J.F.2
  • 41
    • 0017155490 scopus 로고
    • Establishment and characterization of a human histiocytic lymphoma cell line (U-937)
    • Sundstron C. and Nilsson K. (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int. J. Cancer 17, 565-569.
    • (1976) Int. J. Cancer , vol.17 , pp. 565-569
    • Sundstron, C.1    Nilsson, K.2
  • 42
    • 0027213573 scopus 로고
    • Structural features of human immunoglobulin G that determine isotype-specific differences in C activation
    • Tao M.-H., Smith R. I. F. and Morrison S. L. (1993) Structural features of human immunoglobulin G that determine isotype-specific differences in C activation. J. Exp. Med. 178, 661-667.
    • (1993) J. Exp. Med. , vol.178 , pp. 661-667
    • Tao, M.-H.1    Smith, R.I.F.2    Morrison, S.L.3
  • 43
    • 0026504051 scopus 로고
    • Lymphocyte adhesion through very late antigen 4: Evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional a4 integrin counter-receptor on stimulated endothelium
    • Vonderheide R. H., Springer T. A. (1992) Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional a4 integrin counter-receptor on stimulated endothelium. J. Exp. Med. 175, 1422-1433.
    • (1992) J. Exp. Med. , vol.175 , pp. 1422-1433
    • Vonderheide, R.H.1    Springer, T.A.2
  • 44
    • 0028208244 scopus 로고
    • Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4
    • Vonderheide R. H., Tedder T. F., Springer T. A. and Staunton D. E. (1994) Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. J. Cell Biol. 125, 215-222.
    • (1994) J. Cell Biol. , vol.125 , pp. 215-222
    • Vonderheide, R.H.1    Tedder, T.F.2    Springer, T.A.3    Staunton, D.E.4
  • 45
    • 0029152790 scopus 로고
    • The main infiltrating cell in xenograft rejection is a CD4(+) macrophage and not a T lymphocyte
    • Wallgren A. C., Karlssonparra A. and Korsgren O. (1995) The main infiltrating cell in xenograft rejection is a CD4(+) macrophage and not a T lymphocyte. Transplantation 60, 594-601.
    • (1995) Transplantation , vol.60 , pp. 594-601
    • Wallgren, A.C.1    Karlssonparra, A.2    Korsgren, O.3
  • 46
    • 0028889431 scopus 로고
    • Human anti-porcine xenogeneic T cell response. Evidence for allele specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition
    • Yamada K., Sachs D. H. and DerSimonian H. (1995) Human anti-porcine xenogeneic T cell response. Evidence for allele specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J. Immun. 155, 5249-5256.
    • (1995) J. Immun. , vol.155 , pp. 5249-5256
    • Yamada, K.1    Sachs, D.H.2    DerSimonian, H.3
  • 47
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
    • Yednock T. A., Cannon C., Fritz L. C., Sanchex-Madrid F., Steinman L. and Karin N. (1992) Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 356, 63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchex-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 49
    • 0027945261 scopus 로고
    • Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies
    • Zeng Y., Gage A., Montag A., Rothlein R., Thistlethwaite J. R. and Bluestone J. A. (1994) Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies. Transplantation 58, 681-689.
    • (1994) Transplantation , vol.58 , pp. 681-689
    • Zeng, Y.1    Gage, A.2    Montag, A.3    Rothlein, R.4    Thistlethwaite, J.R.5    Bluestone, J.A.6


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