Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells

Molecular Immunology

Volumn 34, Issue 6, 1997, Pages 441-452

  Mueller, John P ^a   Giannoni, Michelle A ^a   Hartman, Sandra L ^a   Elliott, Eileen A ^a   Squinto, Stephen P ^a   Matis, Louis A ^a   Evans, Mark J ^a  

^a ALEXION PHARMACEUTICALS   (United States)

Author keywords

Adhesion molecules; Antibodies; Fc receptors; Inflammation; Xenotransplantation

Indexed keywords

BETA1 INTEGRIN; IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ARTICLE; CHIMERA; ENDOTHELIUM CELL; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKOCYTE ADHERENCE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE ACTIVATION; XENOTRANSPLANTATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CELL ADHESION; CELL LINE; ENDOTHELIUM, VASCULAR; EPITOPE MAPPING; HUMANS; IMMUNOGLOBULIN G; LEUKOCYTES; MOLECULAR SEQUENCE DATA; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; SWINE; VASCULAR CELL ADHESION MOLECULE-1;

ANIMALIA; PRIMATES; SUIDAE; SUS SCROFA;

EID: 0030761203     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00042-4     Document Type: Article

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