Preparation and functional properties of monoclonal antibodies to human, mouse and rat OX-2

Immunology Letters

Volumn 68, Issue 2-3, 1999, Pages 311-315

  Ragheb, Rafik ^a   Abrahams, S ^b   Beecroft, R ^c   Hu, J ^a   Ni, J ^a   Ramakrishna, V ^a   Yu, G ^a   Gorczynski, R M ^a,d  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b BioSci Research Canada Ltd   (Canada)

^c Immuno Precise Antibodies Ltd   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cytokine production; Human; Hybridoma; Monoclonal antibodies; Mouse; OX 2

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; CHO CELL; CONFERENCE PAPER; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE CONSTRUCT; GENETIC TRANSFECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOREACTIVITY; KIDNEY GRAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, SURFACE; HUMANS; INTERFERON TYPE II; INTERLEUKINS; LYMPHOCYTE CULTURE TEST, MIXED; MEMBRANE GLYCOPROTEINS; MICE; RATS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY;

EID: 0033151545     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(99)00060-7     Document Type: Conference Paper

References (12)

1. Chen Z., Zeng H., Gorczynski R.M. Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene. BBA Mol. Basis Dis. 1362:1997;6-10.
2. Barclay A.N. Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX-2 antigens. Immunology. 44:1981;727-736.
3. Borriello F., Lederer J., Scott S., Sharpe A.H. MRC OX-2 defines a novel T cell costimulatory pathway. J. Immunol. 158:1997;4549-4554.
4. Gorczynski R.M., Chen Z., Fu X.M., Zeng H. Increased expression of the novel molecule Ox-2 is involved in prolongation of murine renal allograft survival. Transplantation. 65:1998;1106-1114.
5. Preston S., Wright G.J., Starr K., Barclay A.N., Brown M.H. The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages. Eur. J. Immunol. 27(8):1997;1911-1918.
6. Gorczynski R.M., Cohen Z., Fu X.M., Hua Z., Sun Y.L., Chen Z. Interleukin-13, in combination with anti interleukin-12, increases graft prolongation after portal venous immunization with cultured allogeneic bone marrow-derived dendritic cells. Transplantation. 62:1996;1592-1600.
7. Kohler G., Milstein C. Preparation of monoclonal antibodies. Nature. 25:1975;256-259.
8. McCaughan G.W., Clark M.J., Hurst J., Grosveld F., Barclay A.N. The gene for MRC OX-2 membrane glycoprotein is localized on human chromosome 3. Immunogenetics. 25:1987;133-135.
9. Gorczynski R.M., Chen Z., Zeng H., Gorczynski L., Terzioglu E. Analysis of cytokine production and V beta T-cell receptor subsets in irradiated recipients receiving portal or peripheral venous reconstitution with allogeneic bone marrow cells with or without additional anti-cytokine monoclonal antibodies. Immunology. 93:1998;221-229.
10. Gorczynski R.M. Immunosuppression induced by hepatic portal venous immunization spares reactivity in IL-4 producing T lymphocytes. Immunol. Lett. 33:1992;67-77.
11. Gorczynski R.M., Hozumi N., Wolfe S.W., Chen Z. Interleukin-12, in combination with anti-interleukin-10, reverses graft prolongation after portal venous immunization. Transplantation. 60:1995;1337-1341.
12. Schwartz R.H. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1996;1-8.