Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′- demethylepipodophyllotoxin ether

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 2, 2008, Pages 179-188

  Yang, Tuan Min ^a   Guo, Shi Fang ^b   Chen, Chang Rui ^c   Zhang, Xiao Yu ^d   Li, Wen Guang ^d  

^a XI'AN MEDICAL UNIVERSITY   (China)

^b GANSU PROVINCIAL HOSPITAL   (China)

^c FUDAN UNIVERSITY   (China)

^d LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 O AMINO PHENOL 4' DEMETHYLEPIPODOPHYLLOTOXIN ETHER; ANTINEOPLASTIC AGENT; CALCIUM; MAGNESIUM; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN K 562; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; DRUG INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LASER MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; OSTEOSARCOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE NEOPLASMS; CALCIUM; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ETHERS; FLOW CYTOMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNESIUM; MEMBRANE POTENTIAL, MITOCHONDRIAL; OSTEOSARCOMA; PODOPHYLLOTOXIN; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 38949163272     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.2.0006     Document Type: Article

References (38)

1. Bolduc, J. S., Denizeau, F., Jumarie, C. (2004) Cadmium-induced mitochondrial membrane-potential dissipation does not necessarily require cytosolic oxidative stress: studies using rhodamine-123 fluorescence unquenching. Toxicol. Sci. 77: 299-306
2. 2+ is inhibited by a variety of structurally unrelated inhibitors. Biochem. Cell Biol. 72: 631-638
3. Cotter, T. G., Fernandes, R. S. (1993) Activation of a calcium magnesium independent endonuclease in human leukemic cell apoptosis. Anticancer Res. 13: 1253-1259
4. Dahlin, D. C., Coventry, M. B. (1967) Osteogenic sarcoma. A study of six hundred cases. J. Bone Joint Surg. Am. 49: 101-110
5. DeVita, V. T., Hellman, S., Rosenberg, S. A. (1997) Sarcomas of the soft tissues and bone. In: Cancer: principles & practice of oncology. 5th edn, pp 1731-1852
6. Eilber, F., Giuliano, A., Eckardt, J., Patterson, K., Moseley, S., Goodnight, J. (1987) Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J. Clin. Oncol. 5: 21-26
7. Ferguson, W. S., Goorin, A. M. (2001) Current treatment of osteosarcoma. Cancer Invest. 19: 292-315
8. Friedman, M. A., Carter, S. K. (1972) The therapy of osteogenic sarcoma: current status and thoughts for the future. J. Surg. Oncol. 4: 482-510
9. Goorin, A. M., Harris, M. B., Bernstein, M., Ferguson, W., Devidas, M., Siegal, G. P., Gebhardt, M. C., Schwartz, C. L., Link, M., Grier, H. E. (2002) Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a Pediatric Oncology Group trial. J. Clin. Oncol. 20: 426-y433
10. Gordaliza, M., Garcia, P. A., Miguel del Corral, J. M., Castro, M. A., Gomez-Zurita, M. A. (2004) Podophyllotoxin: distribution, sources, application and new cytotoxic derivatives. Toxicon 44: 441-459
11. Gottlieb, R. A., Nordberg, J., Skowronski, E., Babior, B. M. (1996) Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc. Natl Acad. Sci. 93: 654-658
12. Halliwell, B., Gutteridge, J. M. C. (1999) Free radicals, other reactive species, and disease. In: Halliwell, B., Gutteridge, J. M. C. (eds) Free radicals in biology and medicine. Oxford University Press, Oxford, UK, pp 617-783
13. Harris, M. B., Cantor, A. B., Goorin, A. M., Ayala, A., Ferguson, W. S., Holbrook, T., Link, M. P. (1995) Treatment of osteosarcoma with ifosfamide: comparison of response in pediatric patients with recurrent disease versus patients previously untreated: a Pediatric Oncology Group study. Med. Pediatr. Oncol. 24: 87-92
14. Harris, M. B., Gieser, P., Goorin, A. M., Ayala, A., Shochat, S. J., Ferguson, W. S., Holbrook, T., Link, M. P. (1998) Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group study. J. Clin. Oncol. 16: 3641-3648
15. Hirpara, J. L., Clement, M. V., Pervaiz, S. (2001) Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J. Biol. Chem. 276: 514-521
16. Kaste, S. C., Pratt, C. B., Cain, A. M., Jones-Wallace, D. J., Rao, B. N. (1999) Metastases detected at the time of diagnosis of primary pediatric extremity osteosarcoma at diagnosis: imaging features. Cancer 86: 1602-1608
17. Li, W. G., Zhang, X. Y., Wu, Y. J., Tian, X. (2002) Antioxidative activity of spin labeled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 23: 727-732
18. Link, M. P., Eilber, F. (1989) Pediatric oncology: osteosarcoma. In: Pizzo, P. A., Poplack, D. G. (eds) Principles and practice of pediatric oncology. Lippincott, Philadelphia, pp 689-711
19. Link, M. P., Goorin, A. M., Miser, A. W., Green, A. A., Pratt, C. B., Belasco, J. B., Pritchard, J., Malpas, J. S., Baker, A. R., Kirkpatrick, J. A. (1986) The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N. Engl. J. Med. 314: 1600-1606
20. Link, M. P., Goorin, A. M., Horowitz, M., Meyer, W. H., Belasco, J., Baker, A., Ayala, A., Shuster, J. (1991) Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study. Clin. Orthop. Relat. Res. 270: 8-14
21. Marcove, R. C., Mike, V., Hajek, J. V., Levin, A. G., Hutter, R. V. (1970) Osteogenic sarcoma under the age of twenty-one. A review of one hundred and forty-five operative cases. J. Bone Joint Surg. Am. 52: 411-423
22. McConkey, D. J., Orrenius, S. (1996) The role of calcium in the regulation of apoptosis. J. Leukocyte Biol. 59: 775-783
23. 2+ concentration. Arch. Biochem. Biophys. 269: 365-370
24. Meyers, P. A., Gorlick, R. (1997) Osteosarcoma. Pediatr. Clin. North Am. 44: 973-989
25. Meyers, P. A., Heller, G., Healey, J., Huvos, A., Lane, J., Marcove, R., Applewhite, A., Vlamis, V., Rosen, G. (1992) Chemotherapy for nonmetastatic osteogenic sarcoma: The Memorial Sloan-Kettering experience. J. Clin. Oncol. 10: 5-15
26. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63
27. Nicholls, D. G., Ward, M. W. (2000) Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts. Trends Neurosci. 23: 166-174
28. Provisor, A. J., Ettinger, L. J., Nachman, J. B., Krailo, M. D., Makley, J. T., Yunis, E. J., Huvos, A. G., Betcher, D. L., Baum, E. S., Kisker, C. T., Miser, J. S. (1997) Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group. J. Clin. Oncol. 15: 76-84
29. Rosen, G., Forscher, C. A., Mankin, H. J., (2000) Neoplasms of bone and soft tissue: bone tumors. In: Bast, R. C. J., Kufe, D. W., Pollock, R. E. (eds) Cancer medicine. 5th edn, Decker Inc, Hamilton, Canada, BC, pp 1870-1902
30. Silva, C. P., Oliveira, C. R., Lima, M. C. P. (1996) Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes. Biochem. Pharmacol. 51: 1331-1340
31. Simon, H. U., Haj-Yehia, A., Levi-Schaffer, F. (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418
32. Than, T. A., Ogino, T., Omori, M., Okada, S. (2001) Monochloramine inhibits etoposide induced apoptosis with an increase in DNA aberration. Free Radic. Biol. Med. 30: 932-940
33. Tian, X., Zhang, F. M., Li, W. G. (2002) Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congeners. Life Sci. 70: 2433-2443
34. Weinfeld, M. S., Dudley, H. R. (1962) Osteogenic sarcoma: a follow-up study of the ninety-four cases observed at the Massachusetts General Hospital from 1920 to 1960. Am. J. Orthop. 44-A: 269-276
35. Wenzel, U., Nickel, A., Kuntz, S., Daniel, H. (2004) Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. Carcinogenesis 25: 703-712
36. Wyllie, A. H., Kerr, J. F. R., Currie, A. R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68: 251-306
37. Yalamati, D., William, L. J. (1998) Podophyllotoxins: current status and recent developments. Curr. Med. Chem. 5: 205-252
38. Zhang, X. Y., Bai, D. C., Wu, Y. J., Li, W. G., Liu, N. F. (2005) Proanthocyanidin from grape seeds enhances antineoplastic effect of doxorubicin both in vitro and in vivo. Pharmazie 60: 533-538