B-lymphocyte and plasma cell clonal expansion in monosymptomatic optic neuritis cerebrospinal fluid

Annals of Neurology

Volumn 56, Issue 1, 2004, Pages 97-107

  Haubold, Kurt ^a   Owens, Gregory P ^a   Kaur, Paramjit ^a   Ritchie, Alanna M ^a   Gilden, Donald H ^a   Bennett, Jeffrey L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; SYNDECAN 1;

ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CASE REPORT; CELL POPULATION; CEREBROSPINAL FLUID CYTOLOGY; CHRONIC INFLAMMATION; CLONAL VARIATION; DEMYELINATION; FEMALE; GENE AMPLIFICATION; GENE REARRANGEMENT; GERM LINE; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; MALE; MULTIPLE SCLEROSIS; OPTIC NERVE DISEASE; PLASMA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SOMATIC MUTATION;

AMINO ACID SEQUENCE; ANTIGENS, CD19; B-LYMPHOCYTES; BASE SEQUENCE; CELL SEPARATION; COMPLEMENTARITY DETERMINING REGIONS; FLOW CYTOMETRY; HUMANS; IMMUNE SYSTEM; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; OPTIC NEURITIS; PLASMA CELLS; PROTEOGLYCANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNDECAN-1; SYNDECANS;

EID: 3042791881     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20152     Document Type: Article

References (20)

1. Jin YP, de Pedro-Cuesta J, Soderstrom M, Link H. Incidence of optic neuritis in Stockholm, Sweden, 1990-1995. II. Time and space patterns. Arch Neurol 1999;56:975-980.
2. Jin YP, de Pedro-Cuesta J, Soderstrom M, et al. Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis. J Neurol Sci 2000;181:56-64
3. Rolak LA, Beck RW, Paty DW, et al. Cerebrospinal fluid in acute optic neuritis: experience of the optic neuritis treatment trial. Neurology 1996;46:368-372.
4. Ghezzi A, Martinelli V, Torri V, et al. Long-term follow-up of isolated optic neuritis: the risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical tests. J Neurol 1999;246:770-775.
5. Soderstrom M, Ya-Ping J, Hillert J, Link H. Optic neuritis: prognosis for multiple sclerosis from MRI, CSF, and HLA findings. Neurology 1998;50:708-714.
6. Sorensen T, Frederiksen J, Bronnum-Hansen H, Petersen H. Optic neuritis as onset manifestation of multiple sclerosis: a nationwide long-term survey. Neurology 1999;53:473-478.
7. H4 germline segments in an acute multiple sclerosis brain. Ann Neurol 1998;43:236-243.
8. Owens G, Burgoon M, Anthony J, et al. The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes. Clin Immunol 2001;98:258-263.
9. Baranzini S, Jeong M, Butunoi C, et al. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 1999;163:5133-5144.
10. Smith-Jensen T, Burgoon M, Anthony J, et al. Comparison of the IgG heavy chain sequences in MS and SSPE brains reveals an antigen-driven response. Neurology 2000;54:1227-1232.
11. Qin Y, Duquette P, Zhang Y, et al. Clonal expansion and somatic hypermutation of VH genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 1998;102:1045-1050.
12. Colombo M, Dono M, Gazzola P, et al. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J Immunol 2000;164:2782-2789.
13. Owens G, Ritchie A, Burgoon M, et al. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J Immunol 2003;171:2725-2733.
14. Subira D, Castanon S, Aceituno E, et al. Flow cytometric analysis of cerebrospinal fluid samples and its usefulness in routine clinical practice. Am J Clin Pathol 2002;117:952-958.
15. Qin Y, Duquette P, Zhang Y, et al. Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Lab Invest 2003;83:1081-1088.
16. Wang X, Stollar B. Human immunoglobulin variable region gene analysis by single cell RT-PCR. J Immunol Meth 2000; 244:217-225.
17. Brezinschek H, Brezinschek R, Lipsky P. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995;155:190-202.
18. Beck RW, Trobe JD, Moke PS, et al. High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial. Arch Ophthalmol 2003;121:944-949.
19. Jin YP, de Pedro-Cuesta J, Huang YH, Soderstrom M. Predicting multiple sclerosis at optic neuritis onset. Mult Scler 2003; 9:135-141.
20. Ritchie AM, Gilden DH, Williamson RA, Burgoon MP, Yu X, Helm K, Corboy JR, Owens GP. Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol 2004, in press.