Effects of the Proteasome Inhibitor Bortezomib on Gene Expression Profiles of Pancreatic Cancer Cells

Journal of Surgical Research

Volumn 145, Issue 1, 2008, Pages 111-123

  Tang, Zhi Yu ^a,b   Wu, Yu Lian ^a   Gao, Shun Liang ^a   Shen, Hong Wei ^a  

^a Second Affiliated Hospital   (China)

^b Shenyang 463 Hospital   (China)

Author keywords

oligonucleotide microarray; pancreatic cancer; proteasome inhibitor

Indexed keywords

BORTEZOMIB; GEMCITABINE; PROTEASOME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG SENSITIVITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BORONIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYCYTIDINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P-GLYCOPROTEIN; PANCREATIC NEOPLASMS; PROTEASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZINES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 38949110712     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.03.061     Document Type: Article

References (43)

1. Henne-Bruns D., Vogel I., Luttges J., et al. Ductal adenocarcinoma of the pancreas head: Survival after regional versus extended lymphadenectomy. Hepatogastroenterology 45 (1998) 855
2. Mukaiya M., Hirata K., Satoh T., et al. Lack of survival benefit of extended lymph node dissection for ductal adenocarcinoma of the head of the pancreas: Retrospective multi-institutional analysis in Japan. World J Surg 22 (1998) 248
3. Gudjonsson B. Cancer of the pancreas. Fifty years of surgery. Cancer 60 (1987) 2284
4. Beger H.G., Rau B., Gansauge F., et al. Treatment of pancreatic cancer: Challenge of the facts. World J Surg 27 (2003) 1075
5. Greenlee R.T., Murray T., Bolden S., et al. Cancer statistics, 2000. CA Cancer J Clin 50 (2000) 7
6. Evans D.B., Lee J.E., Pisters P.W., et al. Advances in the diagnosis and treatment of adenocarcinoma of the pancreas. Cancer Treat Res 90 (1997) 109
7. Evans D.B., Abbruzzese J.L., and Rich T.A. Cancer of the pancreas. In: DeVita V.T., Hellman S., and Rosenberg A.S. (Eds). Cancer, Principles and Practice of Oncology (1997), J. B. Lippincott Co, Philadelphia 1054
8. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 79 (1994) 13
9. Adams J., Palombella V.J., Sausville E.A., et al. Proteasome inhibitors: A novel class of potent and effective antitumor agents. Cancer Res 59 (1999) 2615
10. Richardson P.G., Barlogie B., Berenson J., et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348 (2003) 2609
11. Orlowski R.Z. The role of the ubiquitin-proteasome pathway in apoptosis. Cell Death Differ 6 (1999) 303
12. Grimm L.M., and Osborne B.A. Apoptosis and the proteasome. Results Probl Cell Differ 23 (1999) 209
13. Dennis Jr. G., Sherman B.T., Hosack D.A., et al. DAVID: Database for Annotation. Visualization and Integrated Discovery. Genome Biol 4 (2003) P3
14. Akada M., Crnogorac-Jurcevic T., Lattimore S., et al. Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin Cancer Res 11 (2005) 3094
15. Zazzeroni F., Papa S., Algeciras-Schimnich A., et al. Gadd45-β mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood 102 (2003) 3270
16. Chen Z., Clark S., Birkeland M., et al. Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45)α andβ messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. Cancer Lett 188 (2002) 127
17. De Smaele E., Zazzeroni F., Papa S., et al. Induction of gadd45-β by NF-κB down-regulates proapoptotic JNK signaling. Nature 414 (2001) 308
18. Yang W., Monroe J., Zhang Y., et al. Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cells. Cancer Lett 243 (2006) 217
19. Zhang N., Ahsan M.H., Zhu L., et al. NF-κB and not the MAPK signaling pathway regulates GADD45β expression during acute inflammation. J Biol Chem 280 (2005) 21400
20. Wei W., Yang H., Menconi M., et al. Treatment of cultured myotubes with the proteasome inhibitor β-lactone increases the expression of the transcription factor c/EBPβ. Am J Physiol Cell Physiol 292 (2007) C216
21. Vij N., Fang S., and Zeitlin P.L. Selective inhibition of endoplasmic reticulum-associated degradation rescues δF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: Therapeutic implications. J Biol Chem 281 (2006) 17369
22. Obeng E.A., Carlson L.M., Gutman D.M., et al. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107 (2006) 4907
23. Zimmermann J., Erdmann D., Lalande I., et al. Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF3. GADD153 and MAD1. Oncogene 19 (2000) 2913
24. Kojima E., Takeuchi A., Haneda M., et al. The function of GADD34 is a recovery from a shutoff of protein synthesis-induced by ER stress: Elucidation by GADD34-deficient mice. FASEB J 17 (2003) 1573
25. Hung W.J., Roberson R.S., Taft J., et al. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. Mol Cell Biol 23 (2003) 3477
26. Garrido C., Bruey J.M., Fromentin A., et al. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J 13 (1999) 2061
27. Mehlen P., Kretz-Remy C., Preville X., et al. Human hsp27, drosophila hsp27, and human αB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFα-induced cell death. EMBO J 15 (1996) 2695
28. Rogalla T., Ehrnsperger M., Preville X., et al. Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor α by phosphorylation. J Biol Chem 274 (1999) 18947
29. Garrido C., Schmitt E., Cande C., et al. HSP27 and HSP70: Potentially oncogenic apoptosis inhibitors. Cell Cycle 2 (2003) 579
30. Mitsiades N., Mitsiades C.S., Poulaki V., et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 99 (2002) 14374
31. Nawrocki S.T., Carew J.S., Pino M.S., et al. Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res 65 (2005) 11658
32. Travers K.J., Patil C.K., Wodicka L., et al. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101 (2000) 249
33. Schroder M., and Kaufman R.J. ER stress and the unfolded protein response. Mutat Res 569 (2005) 29
34. Mori K. Frame switch splicing and regulated intra-membrane proteolysis: Key words to understand the unfolded protein response. Traffic 4 (2003) 519
35. Lu P.D., Jousse C., Marciniak S.J., et al. Cytoprotection by preemptive conditional phosphorylation of translation initiation factor 2. EMBO J 23 (2004) 169
36. Sitia R., and Braakman I. Quality control in the endoplasmic reticulum protein factory. Nature 426 (2003) 891
37. Nencioni A., Grunebach F., Patrone F., et al. Proteasome inhibitors: Antitumor effects and beyond. Leukemia 21 (2007) 30
38. Zaarur N., Gabai V.L., Porco Jr. J.A., et al. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res 66 (2006) 1783
39. Liptay S., Weber C.K., Ludwig L., et al. Mitogenic and antiapoptotic role of constitutive NF-κB/Rel activity in pancreatic cancer. Int J Cancer 105 (2003) 735
40. Chandler N.M., Canete J.J., and Callery M.P. Increased expression of NF-κ B subunits in human pancreatic cancer cells. J Surg Res 118 (2004) 9
41. Li L., Aggarwal B.B., Shishodia S., et al. Nuclear factor-κB and IκB kinase are constitutively active in human pancreatic cells and their down-regulation by curcumin (diferuloyl methane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 01 (2004) 2351
42. Arlt A., Gehrz A., Muerkoster S., et al. Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 22 (2003) 3243
43. Banerjee S., Zhang Y., Ali S., et al. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 65 (2005) 9064